Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Autor: Doria-Rose, Nicole A., Schramm, Chaim A., Gorman, Jason, Moore, Penny L., Bhiman, Jinal N., Dekosky, Brandon J., Ernandes, Michael J., Georgiev, Ivelin S., Kim, Helen J., Pancera, Marie, Staupe, Ryan P., Altae-Tran, Han R., Bailer, Robert T., Crooks, Ema T., Cupo, Albert, Druz, Aliaksandr, Garrett, Nigel J., Hoi, Kam H., Kong, Rui, Louder, Mark K., Longo, Nancy S., McKee, Krisha, Nonyane, Molati, O'Dell, Sijy, Roark, Ryan S., Rudicell, Rebecca S., Schmidt, Stephen D., Sheward, Daniel J., Soto, Cinque, Wibmer, Constantinos Kurt, Yang, Yongping, Zhang, Zhenhai, Mullikin, James C., Binley, James M., Sanders, Rogier W., Wilson, Ian A., Moore, John P., Ward, Andrew B., Georgiou, George, Williamson, Carolyn, Abdool Karim, Salim S., Morris, Lynn, Kwong, Peter D., Shapiro, Lawrence, Mascola, John R., Becker, Jesse, Benjamin, Betty, Blakesley, Robert, Bouffard, Gerry, Brooks, Shelise, Coleman, Holly, Dekhtyar, Mila, Gregory, Michael, Guan, Xiaobin, Gupta, Jyoti, Han, Joel, Hargrove, April, Ho, Shi-ling, Johnson, Taccara, Legaspi, Richelle, Lovett, Sean, Maduro, Quino, Masiello, Cathy, Maskeri, Baishali, McDowell, Jenny, Montemayor, Casandra, Mullikin, James, Park, Morgan, Riebow, Nancy, Schandler, Karen, Schmidt, Brian, Sison, Christina, Stantripop, Mal, Thomas, James, Thomas, Pam, Vemulapalli, Meg, Young, Alice

Publikováno v: Nature, 509(7498), 55-62. Nature Publishing Group

Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the developmental pathway by which such antibodies are generated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008282f22e95234be542d331b581a457
https://doi.org/10.1038/nature13036

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Autor: McDowell, Jenny, Maduro, Quino, Zhu, Jiang, Guan, Xiaobin, Roskin, Krishna M., Coleman, Holly, Zhang, Zhenhai, Brooks, Shelise, Liao, Hua-Xin, Gao, Feng, Legaspi, Richelle, Blakesley, Robert, Benjamin, Betty, Lynch, Rebecca, Becker, Jesse, Masiello, Cathy, Johnson, Taccara, Alam, S. Munir, Boyd, Scott D., Zhou, Tongqing, Maskeri, Baishali, Lovett, Sean, Fire, Andrew Z., Dekhtyar, Mila, Han, Joel, Gupta, Jyoti, Schramm, Chaim A., Shapiro, Lawrence, Ho, Shi-ling, Hargrove, April, Bouffard, Gerry, Gregory, Michael

Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8978fc645c15057bc1e23c9fc1e3721e