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Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-(14C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs

Autor: Grunwald, Helge ^a, Hargreaves, Patrick ^a, Gebhardt, Klaus ^a, Klauer, Dominique ^a, Serafyn, Arnaud ^a, Schmitt-Hoffmann, Anne ^a, Schleimer, Michael ^a, Schlotterbeck, Goetz ^b, Wind, Mathias ^{a, *}

Publikováno v: In Journal of Pharmaceutical and Biomedical Analysis November 2013 85:138-144

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Additional file 1: of Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Autor: Hargreaves, Patrick, Daoudlarian, Douglas, Theron, Michel, Kolb, Fabrice, Young, Marianne Manchester, Reis, Bernhard, Tiaden, Andre, Bannert, Bettina, Kyburz, Diego, Manigold, Tobias

Figure S1. Ex vivo effects of RO5459072. RO5459072 led to a dose-dependent p10 accumulation in B cells when compared to monocytes (A). In addition, 80 mM of RO5459072 led to significantly decreased CatS ratios in tear fluid, but not other biocompartm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd2c40cbbe59659f4b6496b7c82ca7f

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Additional file 3: of Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Autor: Hargreaves, Patrick, Daoudlarian, Douglas, Theron, Michel, Kolb, Fabrice, Young, Marianne Manchester, Reis, Bernhard, Tiaden, Andre, Bannert, Bettina, Kyburz, Diego, Manigold, Tobias

Figure S3. Stability of CatS activity in tear fluid upon storage at − 80 °C. Specifically, tear fluid was stored at − 80 °C on the day of sample acquisition for 7–8 days until the first measurement. After testing, they were re-stored at − 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1258f0ca022a017ecf0f669b7c715794

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Additional file 2: of Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Autor: Hargreaves, Patrick, Daoudlarian, Douglas, Theron, Michel, Kolb, Fabrice, Young, Marianne Manchester, Reis, Bernhard, Tiaden, Andre, Bannert, Bettina, Kyburz, Diego, Manigold, Tobias

Figure S2. Antigen-specific T cell responses in healthy controls (HC), assessed by IFN-γ/IL-17 Dual ELISPOT assays for 48 h (A) and BrdU proliferation assays for 72 h (B) following stimulation with 5 μg/ml recombinant SS-A (60kD), SS-B, influenza H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f296aeeaa448f08d283c0c0709910

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