Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Harendra S. Parekh"'
Autor:
Ajjappla Basavaraj Shreya, Abhijeet Pandey, Sanjay Kulkarni, K Vijaya Bhaskar, Harendra S. Parekh, Srinivas Mutalik
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Asenapine maleate (ASPM) is a second-generation atypical antipsychotic that is approved for treating acute schizophrenia and bipolar disorder in adults by the US FDA. The major downside of ASPM therapy is rapid, extensive first-pass hepatic
Externí odkaz:
https://doaj.org/article/924a5d45ee9f450b9f78e6418b794f8f
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects li
Externí odkaz:
https://doaj.org/article/3013e09cf1bb4fb3bcfd3869ba7c4bed
Autor:
Faisal Alsenani, Karnaker R. Tupally, Elvis T. Chua, Eladl Eltanahy, Hamed Alsufyani, Harendra S. Parekh, Peer M. Schenk
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 12, Pp 1834-1841 (2020)
In recent decades, marine microorganisms have become known for their ability to produce a wide variety of secondary bioactive metabolites. Several compounds have been isolated from marine microorganisms for the development of novel bioactives for the
Externí odkaz:
https://doaj.org/article/f77b6393a43a421a920aa7734c5d1afc
Autor:
Preeti Pandey, Saurabh Pandey, Peter J. Cabot, Benjamin Wallwork, Benedict J. Panizza, Harendra S. Parekh
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 7, Pp 914-919 (2019)
To demonstrate safety of a developed intranasal dexamethasone-infused in situ gelling formulation, quantification of a validated clinical biomarker indicative of cytotoxic potential using a human sinonasal explant model was first confirmed. Systemati
Externí odkaz:
https://doaj.org/article/6df71569c58b446a93c1c5da4fa5e9f0
Publikováno v:
Gels, Vol 8, Iss 2, p 99 (2022)
Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled w
Externí odkaz:
https://doaj.org/article/5224a6a716f8461499d1c2b501038939
Autor:
Madeleine S. A. Tan, Preeti Pandey, James R. Falconer, Dan J. Siskind, Alexandra Balmanno, Harendra S. Parekh
Publikováno v:
Gels, Vol 8, Iss 1, p 38 (2022)
(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive so
Externí odkaz:
https://doaj.org/article/58cae52c10f84ce894b2a34a3b801b1a
Publikováno v:
Separations, Vol 8, Iss 9, p 154 (2021)
In this study, supercritical carbon dioxide (scCO2) extractions of cannabinoids were conducted at four different densities (231, 590, 818, and 911 kg/m3) using ethanol (5% w/v) as a co-solvent. The chemical profiles of these cannabinoids were analyse
Externí odkaz:
https://doaj.org/article/3e302337765a475098e235747e34ca00
Publikováno v:
Biology, Vol 10, Iss 6, p 481 (2021)
In this study, the optimal setup of supercritical fluid extraction (SFE) was designed and developed, leading to the quantitation of 11 distinct cannabinoids (cannabidivann (CBDV), tetrahydrocannabivann (THCV), cannabidiol (CBD), cannabigerol (CBG) ca
Externí odkaz:
https://doaj.org/article/7315c27189394cb2adaf8f3bd7ae11b5
Publikováno v:
Pharmaceutics, Vol 6, Iss 4, Pp 584-598 (2014)
The various classes of gene delivery vectors possess distinct advantages and disadvantages, each of which impacts on cargo loading, delivery and, ultimately, its function. With this in mind, herein we report on a small layered double hydroxide (sLDH)
Externí odkaz:
https://doaj.org/article/f602b888987746ce822351e60b50854f
Autor:
Madeleine S. A. Tan, Preeti Pandey, Rink-Jan Lohman, James R. Falconer, Dan J. Siskind, Harendra S. Parekh
Publikováno v:
Molecular pharmaceutics. 19(11)
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) drug delivery offers a promising approach to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26f7787dee2d16610175026e72f275a
https://pubmed.ncbi.nlm.nih.gov/36149013
https://pubmed.ncbi.nlm.nih.gov/36149013