Zobrazeno 1 - 10
of 8 707
pro vyhledávání: '"Harel Weinstein,'
Publikováno v:
Virus Research, Vol 340, Iss , Pp 199283- (2024)
We analyzed the spike protein S1/S2 cleavage of selected strains of a prototype coronavirus, mouse hepatitis virus (MHV) by the cellular protease furin, in order to understand the structural requirements underlying the sequence selectivity of the sci
Externí odkaz:
https://doaj.org/article/53b3265641f7409b993be093e86f8dca
Autor:
Osei-Owusu, James, Kots, Ekaterina, Ruan, Zheng, Mihaljević, Ljubica, Chen, Kevin Hong, Tamhaney, Ami, Ye, Xinyu, Lü, Wei, Weinstein, Harel, Qiu, Zhaozhu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug 01. 119(31), 1-12.
Externí odkaz:
https://www.jstor.org/stable/27172134
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Molecular dynamics simulations reveal the allosteric mechanism leading to an open, lipid scrambling competent state of a mammalian TMEM16F.
Externí odkaz:
https://doaj.org/article/578de32c6a854da4adc4db631a4528a6
Autor:
Hengyi Xie, Harel Weinstein
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Complex mechanisms regulate the cellular distribution of cholesterol, a critical component of eukaryote membranes involved in regulation of membrane protein functions directly and through the physiochemical properties of membranes. StarD4, a member o
Externí odkaz:
https://doaj.org/article/fcb23d257a5e45678ae814fb2a7aead2
Allostery plays a fundament role in most biological processes. However, little theory is available to describe it outside of two-state models. Here we use a statistical mechanical approach to show that the allosteric coupling between two collective v
Externí odkaz:
http://arxiv.org/abs/1609.02059
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The TMEM16 family of transmembrane proteins includes Ca2+-activated phospholipid scramblases (PLS) that can also function as non-selective ion channels. Extensive structural and functional studies have established that a membrane-exposed hydrophilic
Externí odkaz:
https://doaj.org/article/419ddff8c99a4099b989e5b407601db9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Rigid-body motions of protein secondary structure are often implicated in mecha-nisms of protein function. In GPCRs, evidence suggests that intracellular loop 2 (IL2) contains a segment characterized as a helix when the activated receptor trig-gers d
Externí odkaz:
http://arxiv.org/abs/1406.4730
Autor:
LeVine, Michael V., Terry, Daniel S., Khelashvili, George, Siegel, Zarek S., Quick, Matthias, Javitch, Jonathan A., Blanchard, Scott C., Weinstein, Harel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug 01. 116(32), 15947-15956.
Externí odkaz:
https://www.jstor.org/stable/26848449
Autor:
Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conforma
Externí odkaz:
https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1