Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains

Autor: Mostafavi, S, Ortiz-Lopez, A, Bogue, MA, Hattori, K, Pop, C, Koller, D, Mathis, D, Benoist, C, Blair, DA, Dustin, ML, Shinton, SA, Hardy, RR, Shay, T, Regev, A, Cohen, N, Brennan, P, Brenner, M, Kim, F, Rao, TN, Wagers, A, Heng, T, Ericson, J, Rothamel, K, Kreslavsky, T, Fletcher, A, Elpek, K, Bellemare-Pelletier, A, Malhotra, D, Turley, S, Miller, J, Brown, B, Merad, M, Gautier, EL, Jakubzick, C, Randolph, GJ, Monach, P, Best, AJ, Knell, J, Goldrath, A, Jojic, V, Laidlaw, D, Collins, J, Gazit, R, Rossi, DJ, Malhotra, N, Sylvia, K, Kang, J, Bezman, NA, Sun, JC, Min-Oo, G, Kim, CC, Lanier, LL

Publikováno v: Mostafavi, S; Ortiz-Lopez, A; Bogue, MA; Hattori, K; Pop, C; Koller, D; et al.(2014). Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. Journal of Immunology, 193(9), 4485-4496. doi: 10.4049/jimmunol.1401280. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2w43r09r

Copyright © 2014 by The American Association of Immunologists, Inc. All rights reserved. To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological

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Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation

Autor: Best, JA, Blair, DA, Knell, J, Yang, E, Mayya, V, Doedens, A, Dustin, ML, Goldrath, AW, Monach, P, Shinton, SA, Hardy, RR, Jianu, R, Koller, D, Collins, J, Gazit, R, Garrison, BS, Rossi, DJ, Narayan, K, Sylvia, K, Kang, J, Fletcher, A, Elpek, K, Bellemare-Pelletier, A, Malhotra, D, Turley, S, Jojic, V, Shay, T, Regev, A, Cohen, N, Brennan, P, Brenner, M, Kreslavsky, T, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Miller, J, Brown, B, Merad, M, Gautier, EL, Jakubzick, C, Randolph, GJ, Kim, F, Rao, TN, Wagers, A, Heng, T, Painter, M, Ericson, J, Davis, S, Ergun, A, Mingueneau, M, Mathis, D, Benoist, C

Publikováno v: Best, JA; Blair, DA; Knell, J; Yang, E; Mayya, V; Doedens, A; et al.(2013). Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation. Nature Immunology, 14(4), 404-412. doi: 10.1038/ni.2536. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3v72j79j

After infection, many factors coordinate the population expansion and differentiation of CD8+effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+T cell transcriptome throughout in

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

Autor: Gautiar, EL, Shay, T, Miller, J, Greter, M, Jakubzick, C, Ivanov, S, Helft, J, Chow, A, Elpek, KG, Gordonov, S, Mazloom, AR, Ma'Ayan, A, Chua, WJ, Hansen, TH, Turley, SJ, Merad, M, Randolph, GJ, Best, AJ, Knell, J, Goldrath, A, Brown, B, Jojic, V, Koller, D, Cohen, N, Brenner, M, Regev, A, Fletcher, A, Bellemare-Pelletier, A, Malhotra, D, Jianu, R, Laidlaw, D, Collins, J, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Garrison, BS, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D, Benoist, C

Publikováno v: Gautiar, EL; Shay, T; Miller, J; Greter, M; Jakubzick, C; Ivanov, S; et al.(2012). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature Immunology, 13(11), 1118-1128. doi: 10.1038/ni.2419. UCSF: Retrieved from: http://www.escholarship.org/uc/item/50c349sc

We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages r

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Deciphering the transcriptional network of the dendritic cell lineage

Autor: Miller, JC, Brown, BD, Shay, T, Gautier, EL, Jojic, V, Cohain, A, Pandey, G, Leboeuf, M, Elpek, KG, Helft, J, Hashimoto, D, Chow, A, Price, J, Greter, M, Bogunovic, M, Bellemare-Pelletier, A, Frenette, PS, Randolph, GJ, Turley, SJ, Merad, M, Jakubzick, C, Best, AJ, Knell, J, Goldrath, A, Koller, D, Cohen, N, Brennan, P, Brenner, M, Regev, A, Fletcher, A, Malhotra, D, Jianu, R, Laidlaw, D, Collins, J, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D, Benoist, C

Publikováno v: Miller, JC; Brown, BD; Shay, T; Gautier, EL; Jojic, V; Cohain, A; et al.(2012). Deciphering the transcriptional network of the dendritic cell lineage. Nature Immunology, 13(9), 888-899. doi: 10.1038/ni.2370. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4mb583kw

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made

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Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.

Autor: Hayakawa K; Fox Chase Cancer Center, Philadelphia, PA 19111; Kyoko.Hayakawa@fccc.edu., Formica AM; Fox Chase Cancer Center, Philadelphia, PA 19111., Nakao Y; Fox Chase Cancer Center, Philadelphia, PA 19111., Ichikawa D; Fox Chase Cancer Center, Philadelphia, PA 19111.; Division of Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo 105-8512, Japan., Shinton SA; Fox Chase Cancer Center, Philadelphia, PA 19111., Brill-Dashoff J; Fox Chase Cancer Center, Philadelphia, PA 19111., Smith MR; Fox Chase Cancer Center, Philadelphia, PA 19111.; George Washington University Cancer Center, Washington, DC 20052; and., Morse HC 3rd; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852., Hardy RR; Fox Chase Cancer Center, Philadelphia, PA 19111.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Jul 15; Vol. 201 (2), pp. 804-813. Date of Electronic Publication: 2018 Jun 13.