Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hardin Bolte"'
Autor:
Sebastian Giese, Kevin Ciminski, Hardin Bolte, Étori Aguiar Moreira, Seema Lakdawala, Zehan Hu, Quinnlan David, Larissa Kolesnikova, Veronika Götz, Yongxu Zhao, Jörn Dengjel, Y. Eugene Chin, Ke Xu, Martin Schwemmle
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells an
Externí odkaz:
https://doaj.org/article/6ed0845914b74bd29b55b944319e9373
Autor:
Étori Aguiar Moreira, Anna Weber, Hardin Bolte, Larissa Kolesnikova, Sebastian Giese, Seema Lakdawala, Martin Beer, Gert Zimmer, Adolfo García-Sastre, Martin Schwemmle, Mindaugas Juozapaitis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The nucleotide sequence of the eight genomic RNA segments of influenza A virus provides essential packaging signals, but how these sequences are recognized is unknown. Here, Moreira et al. identify conserved amino acids in the viral nucleoprotein tha
Externí odkaz:
https://doaj.org/article/fd2af3891b1d4a18955cefaa09570b16
Publikováno v:
Viruses, Vol 8, Iss 6, p 165 (2016)
Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a
Externí odkaz:
https://doaj.org/article/b3216f52edc24f10b0002287a864c0ae
Autor:
Celia Jakob, Gabriel L Lovate, Daniel Desirò, Lara Gießler, Redmond P Smyth, Roland Marquet, Kevin Lamkiewicz, Manja Marz, Martin Schwemmle, Hardin Bolte
Publikováno v:
Nucleic Acids Research.
A fundamental step in the influenza A virus (IAV) replication cycle is the coordinated packaging of eight distinct genomic RNA segments (i.e. vRNAs) into a viral particle. Although this process is thought to be controlled by specific vRNA–vRNA inte
Publikováno v:
Nucleic acids research. 50(16)
The genome of influenza A virus (IAV) consists of eight unique viral RNA segments. This genome organization allows genetic reassortment between co-infecting IAV strains, whereby new IAVs with altered genome segment compositions emerge. While it is kn
Publikováno v:
Journal of Virology, 93(4):e01861-18. American Society for Microbiology
The genome of influenza A virus is organized into eight ribonucleoproteins, each composed of a distinct RNA segment bound by the viral polymerase and oligomeric viral nucleoprotein. Packaging sequences unique to each RNA segment together with specifi
Publikováno v:
Journal of virology. 92(16)
The BAF-chromatin remodeling complex, with its mutually exclusive ATPases SMARCA2 and SMARCA4, is essential for the transcriptional activation of numerous genes, including a subset of interferon-stimulated genes (ISGs). Here, we show that C-terminall
Autor:
Hardin Bolte, Étori Aguiar Moreira, Ke Xu, Kevin Ciminski, Yongxu Zhao, Larissa Kolesnikova, Seema S. Lakdawala, Jörn Dengjel, Quinnlan David, Veronika Götz, Sebastian Giese, Y. Eugene Chin, Martin Schwemmle, Zehan Hu
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Lysine acetylation is a post-translational modification known to regulate protein functions. Here we identify several acetylation sites of the influenza A virus nucleoprotein (NP), including the lysine residues K77, K113 and K229. Viral growth of mut
Publikováno v:
Journal of Biological Chemistry. 289:20067-20077
In influenza A virus-infected cells, replication and transcription of the viral genome occurs in the nucleus. To be packaged into viral particles at the plasma membrane, encapsidated viral genomes must be exported from the nucleus. Intriguingly, the
Autor:
Martin Schwemmle, Étori Aguiar Moreira, Samira Locher, Teresa Aydillo, Larissa Kolesnikova, Gert Zimmer, Hardin Bolte, Adolfo García-Sastre
Publikováno v:
Proceedings of the National Academy of Sciences
Two novel influenza A-like viral genome sequences have recently been identified in Central and South American fruit bats and provisionally designated "HL17NL10" and "HL18NL11." All efforts to isolate infectious virus from bats or to generate these vi