Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hardev S. Pandha"'
Autor:
Robert J. Motzer, Jean-François Martini, Xinmeng J. Mu, Michael Staehler, Daniel J. George, Olga Valota, Xun Lin, Hardev S. Pandha, Keith A. Ching, Alain Ravaud
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Based on the S-TRAC results, sunitinib is approved as adjuvant treatment for adult patients at high risk of recurrent RCC following nephrectomy. Here, the authors report the results of an integrated multi-omics tumor analysis of 171 patients from the
Externí odkaz:
https://doaj.org/article/a7d75a60a97442e0a1d0bfad87ff00d3
Autor:
Martin McLaughlin, Malin Pedersen, Victoria Roulstone, Katharina F. Bergerhoff, Henry G. Smith, Harriet Whittock, Joan N. Kyula, Magnus T. Dillon, Hardev S. Pandha, Richard Vile, Alan A. Melcher, Kevin J. Harrington
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 238-249 (2020)
Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the un
Externí odkaz:
https://doaj.org/article/ea1817def2d74912aacb316306d0be16
Publikováno v:
Cancers, Vol 11, Iss 4, p 508 (2019)
The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is fr
Externí odkaz:
https://doaj.org/article/03f7e87155934409bd83e0b743dd1d03
Autor:
Robin J Prestwich, Fiona Errington, Kevin J. Harrington, Hardev S. Pandha, Peter Selby, Alan Melcher
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 2 (2008)
Oncolytic viruses are replication competent, tumor selective and lyse cancer cells. Their potential for anti-cancer therapy is based upon the concept that selective intratumoral replication will produce a potent anti-tumor effect and possibly bystand
Externí odkaz:
https://doaj.org/article/79936686236f41d9b2664095aa5a4698
Autor:
Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Oncolytic virus V937 showed activity and safety with intratumoral administration. This phase 1 study evaluated intravenous V937±pembrolizumab in patients with advanced solid tumors.Methods Patients had advanced non-small cell lung cancer
Externí odkaz:
https://doaj.org/article/07dff5f507bc4d64bce5f819f24c264d
Autor:
Kevin J. Harrington, Alan A. Melcher, Fiona Errington, Hardev S. Pandha, Lucy Heinemann, Richard G. Vile, Brad Thompson, Matt Coffey, Shreerang Bhide, Johann S. De Bono, Christine L. White, Laura Vidal, Katie Twigger
Supplementary Figures S1-S4 from Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and Radiotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85664b98b29e9a1c416ee59c00686f3d
https://doi.org/10.1158/1078-0432.22441318.v1
https://doi.org/10.1158/1078-0432.22441318.v1
Autor:
Alain Ravaud, Maria Lechuga, Anup Patel, Hardev S. Pandha, Allan J. Pantuck, Brigitte Laguerre, Olga Valota, Michelle Casey, Sherry Li, Bernard Escudier, Frede Donskov, Ahmed Magheli, Robert J. Motzer, Michael Staehler, Jean-Francois Martini, Daniel J. George
Association between DFS and genotype subgroups within each treatment group or the combined sunitinib and placebo groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f4893c777a90e7110f194d0e8bb902
https://doi.org/10.1158/1078-0432.22468418.v1
https://doi.org/10.1158/1078-0432.22468418.v1
Autor:
James Spicer, Johann de Bono, Kevin J. Harrington, Richard Vile, Alan A. Melcher, George M. Gill, Matt Coffey, Sarah Rudman, Hardev S. Pandha, Khurum Khan, Victoria Roulstone
Purpose: Reovirus is a wild-type oncolytic virus that is ubiquitous in the environment; most patients are therefore preimmune. Therapeutic administration leads to an increase in neutralizing antireovirus antibody (NARA) titer. We hypothesized that if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0b9b69f54ac9c4bf9614bcc1091f1
https://doi.org/10.1158/1078-0432.c.6523835.v1
https://doi.org/10.1158/1078-0432.c.6523835.v1
Autor:
James Spicer, Johann de Bono, Kevin J. Harrington, Richard Vile, Alan A. Melcher, George M. Gill, Matt Coffey, Sarah Rudman, Hardev S. Pandha, Khurum Khan, Victoria Roulstone
Supplementary Figure 1. Total white blood cell numbers were reduced by higher doses of the cytotoxic CP in later cohorts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ee62ffd3f25f26d4c1745625a5fca4
https://doi.org/10.1158/1078-0432.22458119.v1
https://doi.org/10.1158/1078-0432.22458119.v1
Autor:
Kevin J. Harrington, John Chester, Alan A. Melcher, Geoff D. Hall, Hardev S. Pandha, Richard G. Vile, Karl Mettinger, Brad Thompson, Matt Coffey, Konstantinos N. Syrigos, James Larkin, Martin E. Gore, Kate Newbold, Chris Nutting, MaryAnne Tanay, Mercel Ball, Katie Twigger, Victoria Roulstone, Eleni M. Karapanagiotou
PDF file - 48K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14472fe566c12d44682a8eea19bcd8dd
https://doi.org/10.1158/1078-0432.22445160.v1
https://doi.org/10.1158/1078-0432.22445160.v1