Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Autor: Tobias Kurth, Nadine Pelzer, Hautakangas H, Artto, O T Raitakari, Julie E. Buring, Penninx Bwjh., Christian Erikstrup, Mikko Kallela, Matti Pirinen, Christian Benner, Daniel I. Chasman, Kristian Hveem, Kristoffersen Es, Torben Hansen, Olafur A. Sveinsson, Mika Kähönen, van den Maagdenberg Amjm., Mona Ameri Chalmer, Aarno Palotie, Elisabeth Widen, Thorgeir E. Thorgeirsson, Hreinn Stefansson, Lighart L, Paul M. Ridker, de Boer I, Gisela M. Terwindt, Garbrielsen Me, Jouke J. Hottenga, Kogelman Lja., Arpo Aromaa, Bendik S. Winsvold, Dale R. Nyholt, Ikram Ma, van Dijk Kw, Harder Ave, Martin Dichgans, Rainer Malik, Mohsen Ghanbari, Marianne Bakke Johnsen, Marjo-Ritta Jarvelin, Samuli Ripatti, Paavo Häppölä, Gyda Bjornsdottir, Martti Färkkilä, Anne Heidi Skogholt, Terho Lehtimäki, Sanni Ruotsalainen, Frits R. Rosendaal, Gudrun R. Sigurdardottir, Headache Ha, Gormley P, Kari Stefansson, J.A. Zwart, Oluf Pedersen, Raymond Noordam, Ben Michael Brumpton, Laurent F. Thomas, Karina Banasik, M.G. Hrafnsdottir, Lisanne S. Vijfhuizen, Sølvsten Burgdorf K, Jes Olesen, Sigurdur H. Magnusson, T. Freilinger, Kristen Hagen, Andrea Carmine Belin, Dorret I. Boomsma, Henrik Ullum, Maija Wessman, Ran C, Anna Bjornsdottir

Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. This genome-wide association study (GWAS) of 102,084 migraine cases and 771,257 controls identified 123 loci of which 86 are novel. The loci p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e64e0da2e2c833014db37279373369e
https://doi.org/10.1101/2021.01.20.21249647

Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

Autor: Espen Saxhaug Kristoffersen, Ko Willems van Dijk, Aster V.E. Harder, Rigmor H. Jensen, Patricia Pozo-Rosich, Lisanne S. Vijfhuizen, Michel D. Ferrari, John-Anker Zwart, Laurent F. Thomas, Thomas F. Hansen, Emer O'Connor, G.M. Terwindt, Raymond Noordam, Frits R. Rosendaal, Lisette J. A. Kogelman, Rolf Fronczek, Erling Tronvik, Sigrid Børte, Arn M. J. M. van den Maagdenberg, Irene de Boer, Bendik S. Winsvold, Carmen Fourier

Publikováno v: Annals of Neurology, 90(2), 203-216. WILEY
Scientia
Annals of Neurology
Harder, A V E, Winsvold, B S, Noordam, R, Vijfhuizen, L S, Børte, S, Kogelman, L J A, Boer, I, Tronvik, E, Rosendaal, F R, Willems Van Dijk, K, O'connor, E, Fourier, C, Thomas, L F, Kristoffersen, E S, Fronczek, R, Pozo-rosich, P, Jensen, R H, Ferrari, M D, Hansen, T F, Zwart, J, Terwindt, G M & Maagdenberg, A M J M 2021, ' Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache ', Annals of Neurology, vol. 90, no. 2, pp. 203-216 . https://doi.org/10.1002/ana.26146
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Publisher Copyright: © 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. Objective: Identifying common genetic variants that confer genetic risk for cluster headache. Methods: We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcff5fa4403ed4b892b048f6c58b55c
https://ddd.uab.cat/record/256417

Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor.

Autor: Winsvold BS; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Harder AVE; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Ran C; Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Chalmer MA; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'N. Kirchner', National University A. Jauretche (UNAJ), Florencio Varela, Argentina., Ferkingstad E; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Tripathi KP; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, Uniklinik Köln, Cologne, Germany., Bacchelli E; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Børte S; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Fourier C; Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Petersen AS; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark., Vijfhuizen LS; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Magnusson SH; deCODE genetics/Amgen Inc., Reykjavik, Iceland., O'Connor E; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Bjornsdottir G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Häppölä P; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Wang YF; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Callesen I; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark., Kelderman T; Department of Neurology, Ghent University Hospital, Ghent, Belgium., Gallardo VJ; Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain., de Boer I; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Olofsgård FJ; Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Heinze K; Kiel Migraine and Headache Centre, Kiel, Germany., Lund N; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark., Thomas LF; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; BioCore-Bioinformatics Core Facility, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Hsu CL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Pirinen M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland., Hautakangas H; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Ribasés M; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Department of Psychiatry, Vall d'Hebron University Hospital, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Guerzoni S; AOU Policlinico Modena, Modena University Hospital, Modena, Italy., Sivakumar P; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Yip J; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Heinze A; Kiel Migraine and Headache Centre, Kiel, Germany., Küçükali F; Complex Genetics of Alzheimer's Disease Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Ostrowski SR; Department of Clinical Immunology, Centre of Diagnostic Investigation, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Kristoffersen ES; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of General Practice, University of Oslo, Oslo, Norway.; Department of Neurology, Akershus University Hospital, Lørenskog, Norway., Martinsen AE; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Artigas MS; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Department of Psychiatry, Vall d'Hebron University Hospital, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Lagrata S; Headache and Facial Pain Group, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK., Cainazzo MM; AOU Policlinico Modena, Modena University Hospital, Modena, Italy., Adebimpe J; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Quinn O; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Göbel C; Kiel Migraine and Headache Centre, Kiel, Germany.; Department of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany., Cirkel A; Kiel Migraine and Headache Centre, Kiel, Germany.; Department of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany., Volk AE; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Skogholt AH; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Gabrielsen ME; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Wilbrink LA; Department of Neurology, Zuyderland Hospital, Heerlen, The Netherlands., Danno D; Headache and Facial Pain Group, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK., Mehta D; Headache and Facial Pain Group, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK., Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Willems van Dijk K; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands., Fronczek R; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Wagner M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Scherer M; Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Göbel H; Kiel Migraine and Headache Centre, Kiel, Germany., Sleegers K; Complex Genetics of Alzheimer's Disease Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Sveinsson OA; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Pani L; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL., Zoli M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Ramos-Quiroga JA; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Department of Psychiatry, Vall d'Hebron University Hospital, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain., Dardiotis E; Department of Neurology, Faculty of Medicine, University of Thessaly, Volos, Greece., Steinberg A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurology, Karolinska University Hospital, Stockholm, Sweden., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Sjöstrand C; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurology, Danderyd Hospital, Stockholm, Sweden., Thorgeirsson TE; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Southgate L; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.; Department of Medical & Molecular Genetics, Faculty of Life Sciences & Medicine, King's College London, London, UK., Trembath RC; Department of Medical & Molecular Genetics, Faculty of Life Sciences & Medicine, King's College London, London, UK., Vandrovcova J; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Paemeleire K; Department of Neurology, Ghent University Hospital, Ghent, Belgium., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Fann CS; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Waldenlind E; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurology, Karolinska University Hospital, Stockholm, Sweden., Tronvik E; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Jensen RH; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark., Chen SP; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Medical Research, Division of Translational Research, Taipei Veterans General Hospital, Taipei, Taiwan., Houlden H; Department of Neuromuscular Diseases, Institute of Neurology, University College London, London, UK., Terwindt GM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Kubisch C; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Maestrini E; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Vikelis M; Glyfada Headache Center, Glyfada, Greece., Pozo-Rosich P; Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Belin AC; Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Matharu M; Headache and Facial Pain Group, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK., van den Maagdenberg AMJM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Hansen TF; Department of Neurology, Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen University Hospital, Glostrup, Denmark.; Novo Nordic Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX.; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany., Zwart JA; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Norwegian Centre for Headache Research (NorHEAD), Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Publikováno v: Annals of neurology [Ann Neurol] 2023 Oct; Vol. 94 (4), pp. 713-726. Date of Electronic Publication: 2023 Aug 07.

Migraine, inflammatory bowel disease and celiac disease: A Mendelian randomization study.

Autor: Welander NZ; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Rukh G; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Rask-Andersen M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Harder AVE; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands., van den Maagdenberg AMJM; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands., Schiöth HB; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mwinyi J; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Publikováno v: Headache [Headache] 2023 May; Vol. 63 (5), pp. 642-651. Date of Electronic Publication: 2023 Jan 27.

Genetics of migraine: Delineation of contemporary understanding of the genetic underpinning of migraine.

Autor: de Boer I; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Harder AVE; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Ferrari MD; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., van den Maagdenberg AMJM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Terwindt GM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: g.m.terwindt@lumc.nl.

Publikováno v: Handbook of clinical neurology [Handb Clin Neurol] 2023; Vol. 198, pp. 85-103.