Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Hardegger LA"'
3
Akademický článek
Corrigendum: Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Autor: Lauber BS, Hardegger LA, Alam KA, Lund BA, Dumele O, Harder M, Kuhn B, Engh RA, Diederich F
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Jul 14; Vol. 26 (39), pp. 8664. Date of Electronic Publication: 2020 Jul 02.
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4
Akademický článek
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
Autor: Adams CM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Anderson K; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Artman G 3rd; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Bizec JC; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States., Cepeda R; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Elliott J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Fassbender E; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Ghosh M; Global Drug Development/Technical Research & Development, Novartis Pharmaceutical Corporation , 6201 South Freeway Fort Worth, Texas 76134-2099, United States., Hanks S; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Hardegger LA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Hosagrahara VP; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States., Jaffee B; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Jendza K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Ji N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Johnson L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Lee W; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States., Liu D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Liu F; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Long D; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Ma F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Mainolfi N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Meredith EL; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Miranda K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Peng Y; Ocular Pharmacokinetics and Disposition, Alcon, a Novartis Company , 201 South Freeway, Fort Worth, Texas 76134, United States., Poor S; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Powers J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Qiu Y; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Rao C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Shen S; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Sivak JM; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Solovay C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Tarsa P; Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Woolfenden A; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Zhang C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Zhang Y; Ophthalmology, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Feb 22; Vol. 61 (4), pp. 1622-1635. Date of Electronic Publication: 2018 Feb 05.
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5
Akademický článek
Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Autor: Lauber BS; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09., Hardegger LA; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09., Alam KA; Department of Chemistry, University of Tromsø, Forskningsparken 3, Sykehusvegen 23, 9037 Tromsø (Norway)., Lund BA; Department of Chemistry, University of Tromsø, Forskningsparken 3, Sykehusvegen 23, 9037 Tromsø (Norway)., Dumele O; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09., Harder M; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09., Kuhn B; Small Molecule Research, Roche Innovation Center Basel, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel (Switzerland)., Engh RA; Department of Chemistry, University of Tromsø, Forskningsparken 3, Sykehusvegen 23, 9037 Tromsø (Norway). richard.engh@uit.no., Diederich F; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland), Fax: (+41) 44-632-11-09. diederich@org.chem.ethz.ch.
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Jan 04; Vol. 22 (1), pp. 211-21. Date of Electronic Publication: 2015 Nov 18.
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6
Akademický článek
Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.
Autor: Hardegger LA; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, U.K., Habegger J; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, U.K., Donohoe TJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, U.K.
Publikováno v: Organic letters [Org Lett] 2015 Jul 02; Vol. 17 (13), pp. 3222-5. Date of Electronic Publication: 2015 Jun 18.
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7
Akademický článek
Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments.
Autor: Hardegger LA; Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, HCI, 8093 Zürich, Switzerland., Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Isshiki Y, Morikami K, Shimma N, Haap W, Banner DW, Diederich F
Publikováno v: ChemMedChem [ChemMedChem] 2011 Nov 04; Vol. 6 (11), pp. 2048-54. Date of Electronic Publication: 2011 Sep 06.
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8
Akademický článek
Systematic investigation of halogen bonding in protein-ligand interactions.
Autor: Hardegger LA; Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, HCI, 8093 Zürich, Switzerland., Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F
Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2011 Jan 03; Vol. 50 (1), pp. 314-8.
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9
Akademický článek
Self-association based on orthogonal C=O...C=O interactions in the solid and liquid state.
Autor: Fäh C; Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, CH-8093 Zürich, Switzerland., Hardegger LA, Ebert MO, Schweizer WB, Diederich F
Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Jan 07; Vol. 46 (1), pp. 67-9. Date of Electronic Publication: 2009 Nov 06.
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10
Akademický článek
New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.
Autor: Fäh C; Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, CH-8093, Zürich, Switzerland., Hardegger LA, Baitsch L, Schweizer WB, Meyer S, Bur D, Diederich F
Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2009 Oct 07; Vol. 7 (19), pp. 3947-57. Date of Electronic Publication: 2009 Jul 24.
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