Výsledky vyhledávání - "Hardeep S. Mehta"

Akademický článek

High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip

Autor: Jongmin Woo, Sarah M. Williams, Lye Meng Markillie, Song Feng, Chai-Feng Tsai, Victor Aguilera-Vazquez, Ryan L. Sontag, Ronald J. Moore, Dehong Hu, Hardeep S. Mehta, Joshua Cantlon-Bruce, Tao Liu, Joshua N. Adkins, Richard D. Smith, Geremy C. Clair, Ljiljana Pasa-Tolic, Ying Zhu

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Single-cell proteomics is an emerging technology but protein coverage, throughput and quantitation accuracy are often still insufficient. Here, the authors develop a nested nanowell chip that improves protein recovery, throughput and robustness of is

Externí odkaz: https://doaj.org/article/6d95da1c95fe4f8f92f03a0bae481111

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High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip

Autor: Richard D. Smith, Hardeep S. Mehta, Chai-Feng Tsai, Song Feng, Tao Liu, Dehong Hu, Joshua N. Adkins, Ljiljana Paša-Tolić, Ronald J. Moore, Victor Aguilera-Vazquez, Ying Zhu, Joshua Cantlon-Bruce, Lye Meng Markillie, Jongmin Woo, Ryan L. Sontag, Sarah M. Williams, Geremy Clair

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

Global quantification of protein abundances in single cells could provide direct information on cellular phenotypes and complement transcriptomics measurements. However, single-cell proteomics is still immature and confronts many technical challenges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5370b8c86a3214def0d19d1392f2feb9
https://doi.org/10.1038/s41467-021-26514-2

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A novel high-temperature MAS probe with optimized temperature gradient across sample rotor for in-situ monitoring of high-temperature high-pressure chemical reactions

Autor: Hardeep S. Mehta, Mathew Campos, Nancy M. Washton, David W. Hoyt, Jesse A. Sears, Ying Chen, David J. Heldebrant, Eric D. Walter, Karl T. Mueller, Jotheeswari Kothandaraman

Publikováno v: Solid State Nuclear Magnetic Resonance. 102:31-35

We present a novel nuclear magnetic resonance (NMR) probe design focused on optimizing the temperature gradient across the sample for high temperature magic angle spinning (MAS) experiments using standard rotors. Computational flow dynamics (CFD) sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a416b136aba72ad0f553a72a50b38080
https://doi.org/10.1016/j.ssnmr.2019.06.003

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High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip

Autor: Geremy Clair, Joshua Cantlon, Ryan L. Sontag, Ronald J. Moore, Ying Zhu, Victor Aguilera-Vazquez, Richard D. Smith, Jongmin Woo, Lye Meng Markillie, Ljiljana Paša-Tolić, Joshua N. Adkins, Sarah M. Williams, Hardeep S. Mehta

Global quantification of protein abundances in single cells would provide more direct information on cellular function phenotypes and complement transcriptomics measurements. However, single-cell proteomics (scProteomics) is still immature and confro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::416ac34563da9b6bae459a3f9769199e
https://doi.org/10.1101/2021.02.17.431689

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Critical Water Coverage during Forsterite Carbonation in Thin Water Films: Activating Dissolution and Mass Transport

Autor: Sebastien N. Kerisit, Hardeep S. Mehta, Edmundo Placencia-Gomez, John S. Loring, Odeta Qafoku, Christopher J. Thompson, Trent R. Graham, Eugene S. Ilton

Publikováno v: Environmental sciencetechnology. 54(11)

In geologic carbon sequestration, CO2 is injected into geologic reservoirs as a supercritical fluid (scCO2). The carbonation of divalent silicates exposed to humidified scCO2 occurs in Angstroms to...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bd4c79ea156d022c8fd0bce212863e
https://pubmed.ncbi.nlm.nih.gov/32383859

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Operando MAS NMR Reaction Studies at High Temperatures and Pressures

Autor: Eric D. Walter, Ali Chamas, Long Qi, David W. Hoyt, Jesse A. Sears, Hardeep S. Mehta, Susannah L. Scott

Publikováno v: The Journal of Physical Chemistry C. 122:8209-8215

Operando MAS NMR studies provide unique insights into the details of chemical reactions; comprehensive information about temperature- and time-dependent changes in chemical species is accompanied by similarly rich information about changes in phase a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f23eb7fb73b00a9f278ff50a8bd8fe0
https://doi.org/10.1021/acs.jpcc.7b11442

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Pore-scale supercritical CO2 dissolution and mass transfer under drainage conditions

Autor: Timothy J. Kneafsey, Mart Oostrom, Quanlin Zhou, Chun Chang, Hardeep S. Mehta

Publikováno v: Advances in Water Resources. 100:14-25

Recently, both core- and pore-scale imbibition experiments have shown non-equilibrium dissolution of supercritical CO2 (scCO2) and a prolonged depletion of residual scCO2. In this study, pore-scale scCO2 dissolution and mass transfer under drainage c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eee750ab9fe4bc25cd8737caf828e73f
https://doi.org/10.1016/j.advwatres.2016.12.003

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High-resolution microstrip NMR detectors for subnanoliter samples

Autor: Eric D. Walter, Ryan S. Renslow, Mark C. Butler, Hardeep S. Mehta, Karl T. Mueller, Ying Chen, Nancy M. Washton, Patrick N. Reardon

Publikováno v: Phys. Chem. Chem. Phys.. 19:28163-28174

We present the numerical optimization and experimental characterization of two microstrip-based nuclear magnetic resonance (NMR) detectors. The first detector, introduced in our previous work, was a flat wire detector with a strip resting on a substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5096cf404288391b90890078a7d6b6ff
https://doi.org/10.1039/c7cp03933f

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