Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.

Autor: Fidler TP; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Physiology, University of San Francisco, San Francisco, CA, USA., Dunbar A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim E; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Hardaway B; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Pauli J; Department of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich, Germany., Xue C; Department of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany., Abramowicz S; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Xiao T; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., O'Connor K; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sachs N; Department of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich, Germany., Wang N; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Maegdefessel L; Department of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich, Germany.; Department of Medicine, Karolinska Institute, Stockholm, Sweden., Levine R; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reilly M; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA., Tall AR; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Jan; Vol. 3 (1), pp. 60-75. Date of Electronic Publication: 2024 Jan 11.

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Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.

Autor: Dou H; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Kotini A; Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.)., Liu W; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Fidler T; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Endo-Umeda K; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan (K.E.-U.)., Sun X; Department of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.)., Olszewska M; Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.)., Xiao T; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Abramowicz S; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Yalcinkaya M; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Hardaway B; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Tsimikas S; Department of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.)., Que X; Department of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.)., Bick A; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.B.)., Emdin C; Cardiovascular Research Center, Massachusetts General Hospital, Boston (C.E., P.N.).; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA (C.E., P.N.).; Department of Medicine, Harvard Medical School, Boston, MA (C.E., P.N.)., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Boston (C.E., P.N.).; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA (C.E., P.N.).; Department of Medicine, Harvard Medical School, Boston, MA (C.E., P.N.)., Papapetrou EP; Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.)., Witztum JL; Department of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.)., Wang N; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.)., Tall AR; Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).

Publikováno v: Circulation [Circulation] 2021 Dec 14; Vol. 144 (24), pp. 1940-1954. Date of Electronic Publication: 2021 Nov 30.

Self-Management Ability is an Indirect Mediator of Quality of Life in Heart Transplant

Autor: Kennedy, C.C., Lee, M., Hathcock, M., Thompson, K., Yip, D., Hardaway, B., Griffin, J., Kushwaha, S., Benzo, R.

Publikováno v: In Journal of Heart and Lung Transplantation April 2020 39(4) Supplement:S229-S229

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.

Autor: Fidler TP; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. tpf2103@cumc.columbia.edu., Xue C; Cardiometabolic Precision Medicine Program, Cardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA., Yalcinkaya M; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Hardaway B; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Abramowicz S; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Xiao T; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Liu W; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Thomas DG; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Hajebrahimi MA; Medical Clinic I., Department of Cardiology, LMU Klinikum, Ludwig Maximilian University, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Pircher J; Medical Clinic I., Department of Cardiology, LMU Klinikum, Ludwig Maximilian University, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Silvestre-Roig C; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich, Germany., Kotini AG; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luchsinger LL; Department of Medicine, Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA., Wei Y; Columbia University, New York, NY, USA., Westerterp M; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snoeck HW; Department of Medicine, Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA., Papapetrou EP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schulz C; Medical Clinic I., Department of Cardiology, LMU Klinikum, Ludwig Maximilian University, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Massberg S; Medical Clinic I., Department of Cardiology, LMU Klinikum, Ludwig Maximilian University, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Soehnlein O; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Cardiovascular Prevention (IPEK), LMU Munich, Munich, Germany.; Department of Physiology and Pharmacology (FyFa), Karolinska Institute, Stockholm, Sweden., Ebert B; Department of Medical Oncology, Dana-Faber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Dana-Faber Cancer Institute, Boston, MA, USA., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reilly MP; Cardiometabolic Precision Medicine Program, Cardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA., Libby P; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang N; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. nw30@cumc.columbia.edu., Tall AR; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. art1@cumc.columbia.edu.

Publikováno v: Nature [Nature] 2021 Apr; Vol. 592 (7853), pp. 296-301. Date of Electronic Publication: 2021 Mar 17.