Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung.

Autor: Hardaker, EL¹, Freeman, MS¹, Dale, N¹, Bahra, P¹, Raza, F¹, Banner, KH¹, Poll, C¹, Hardaker, E L¹ (AUTHOR), Freeman, M S (AUTHOR), Banner, K H (AUTHOR)

Publikováno v: British Journal of Pharmacology. Aug2010, Vol. 160 Issue 8, p1985-1996. 12p. 7 Graphs.

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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.

Autor: Hardaker EL; Oncology R&D, AstraZeneca, Cambridge, UK., Sanseviero E; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Karmokar A; Oncology R&D, AstraZeneca, Cambridge, UK., Taylor D; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Milo M; Oncology R&D, AstraZeneca, Cambridge, UK., Michaloglou C; Oncology R&D, AstraZeneca, Cambridge, UK., Hughes A; Oncology R&D, AstraZeneca, Cambridge, UK., Mai M; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., King M; Oncology R&D, AstraZeneca, Cambridge, UK., Solanki A; Oncology R&D, AstraZeneca, Cambridge, UK., Magiera L; Oncology R&D, AstraZeneca, Cambridge, UK., Miragaia R; Oncology R&D, AstraZeneca, Cambridge, UK., Kar G; Oncology R&D, AstraZeneca, Cambridge, UK., Standifer N; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.; Tempest Therapeutics, Brisbane, CA, USA., Surace M; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Gill S; Oncology R&D, AstraZeneca, Cambridge, UK., Peter A; Oncology R&D, AstraZeneca, Cambridge, UK., Talbot S; Oncology R&D, AstraZeneca, Cambridge, UK., Tohumeken S; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Fryer H; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Mostafa A; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Mulgrew K; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Lam C; Oncology R&D, AstraZeneca, Cambridge, UK., Hoffmann S; Imaging and Data Analytics, AstraZeneca, Cambridge, UK., Sutton D; Imaging and Data Analytics, AstraZeneca, Cambridge, UK., Carnevalli L; Oncology R&D, AstraZeneca, Cambridge, UK., Calero-Nieto FJ; Oncology R&D, AstraZeneca, Cambridge, UK., Jones GN; Oncology R&D, AstraZeneca, Cambridge, UK., Pierce AJ; Oncology R&D, AstraZeneca, Cambridge, UK.; Crescendo Biologics Limited, Cambridge, UK., Wilson Z; Oncology R&D, AstraZeneca, Cambridge, UK., Campbell D; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Nyoni L; Oncology R&D, AstraZeneca, Cambridge, UK., Martins CP; Oncology R&D, AstraZeneca, Cambridge, UK., Baker T; CPSS AST, AstraZeneca, Cambridge, UK., Serrano de Almeida G; CPSS AST, AstraZeneca, Cambridge, UK., Ramlaoui Z; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Bidar A; CPSS, Imaging, AstraZeneca, Gothenburg, Sweden., Phillips B; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Boland J; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Iyer S; Oncology R&D, AstraZeneca, Boston, MA, USA., Barrett JC; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Loembé AB; Early Clinical Development, AstraZeneca, Oss, the Netherlands., Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania, Philadelphia, PA, 19104, USA., Duvvuri U; UPMC Department of Otolaryngology and UPMC Hillman Cancer Center, 200 Lothrop St. Suite 500, Pittsburg, PA, 15213, USA., Lou PJ; National Taiwan University Hospital, No. 7, Chung Shan S. Rd. (Zhongshan S. Rd.), Zhongzheng Dist., Taipei City, 10002, Taiwan., Nance MA; VA Pittsburgh Healthcare System, University Drive C, Pittsburg, PA, 15240, USA., Gomez Roca CA; Institut Claudius Regaud-Cancer Comprehensive Center, 1 Avenue Irene Joliot-Curie, IUCT-O, Toulouse, 31059 Cedex 9, France., Cadogan E; Oncology R&D, AstraZeneca, Cambridge, UK., Critichlow SE; Oncology R&D, AstraZeneca, Cambridge, UK., Fawell S; Oncology R&D, AstraZeneca, Boston, MA, USA., Cobbold M; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Dean E; Oncology R&D, AstraZeneca, Cambridge, UK., Valge-Archer V; Oncology R&D, AstraZeneca, Cambridge, UK., Lau A; Oncology R&D, AstraZeneca, Cambridge, UK., Gabrilovich DI; Oncology R&D, AstraZeneca, Gaithersburg, MD, 20878, USA. dmitry.gabrilovich@astrazeneca.com., Barry ST; Oncology R&D, AstraZeneca, Cambridge, UK. simon.t.barry@astrazeneca.com.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 24; Vol. 15 (1), pp. 1700. Date of Electronic Publication: 2024 Feb 24.

Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer.

Autor: Avivar-Valderas A; Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK.; Current address: TiGenix, Parque Tecnológico de Madrid, Tres Cantos, Madrid, Spain., McEwen R; Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Taheri-Ghahfarokhi A; Translational Genomics, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Carnevalli LS; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Hardaker EL; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Maresca M; Translational Genomics, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Hudson K; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK.; Current address: 2TheNth, Adelphi Mill, Bollington, Macclesfield, UK., Harrington EA; Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Cruzalegui F; Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK.; Current address: Pierre Fabre R&D Centre, Toulouse, France.

Publikováno v: Oncotarget [Oncotarget] 2018 Apr 20; Vol. 9 (30), pp. 21444-21458. Date of Electronic Publication: 2018 Apr 20 (Print Publication: 2018).

Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease.

Autor: Catley MC; Respiratory Pharmacology, Airways Diseases, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom., Birrell MA, Hardaker EL, de Alba J, Farrow S, Haj-Yahia S, Belvisi MG

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2008 Jul; Vol. 326 (1), pp. 83-8. Date of Electronic Publication: 2008 Mar 28.