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Embracing model-based designs for dose-finding trials

Autor: Love, S, Brown, S, Weir, C, Harbron, C, Yap, C, Gaschler-Markefski, B, Matcham, J, Caffery, L, McKevitt, C, Clive, S, Craddock, C, Spicer, J, Cornelius, V

Publikováno v: Love, S B, Brown, S, Weir, C J, Harbron, C, Yap, C, Gaschler-Markefski, B, Matcham, J, Caffrey, L, McKevitt, C, Clive, S, Craddock, C, Spicer, J & Cornelius, V 2017, ' Embracing model-based designs for dose-finding trials ', BJC: British Journal of Cancer, vol. 117, no. 3, pp. 332-339 . https://doi.org/10.1038/bjc.2017.186
Love, S B, Brown, S, Weir, C, Harbron, C, Yap, C, Gaschler-markefski, B, Matcham, J, Caffrey, L, Mckevitt, C, Clive, S, Craddock, C, Spicer, J & Cornelius, V 2017, ' Embracing model-based designs for dose-finding trials ', British Journal of Cancer . https://doi.org/10.1038/bjc.2017.186

Background Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose-finding, such as the continual reassessment method (CRM). Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fc56f59c7fa164bc9da98ed969ffcc26
https://kclpure.kcl.ac.uk/ws/files/79971698/Embracing_model_based_designs_LOVE_Firstonline29June2017_GOLD_VoR_CC_BY_.pdf

An adaptive design for updating the threshold value of a continuous biomarker

Autor: Spencer, A.V., Harbron, C., Mander, A., Wason, J., Peers, I.

Potential predictive biomarkers are often measured on a continuous scale, but in practice, a threshold value to divide the patient population into biomarker ‘positive’ and ‘negative’ is desirable. Early phase clinical trials are increasingly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::96fc6b0961fc2170b5af7ca406bb025e
https://eprints.whiterose.ac.uk/118029/1/Spencer_et_al-2016-Statistics_in_Medicine.pdf

Differences in root longevity of some tree species.

Autor: Black, K. E.¹, Harbron, C. G.², Franklin, M.², Atkinson, D.¹, Hooker, J. E.³

Publikováno v: Tree Physiology. Apr1998, Vol. 18 Issue 4, p259-264. 6p. 1 Chart, 2 Graphs.