Development of Kinase Inhibitors via Metal-Catalyzed C-H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Autor: Couly, Florence¹ florence.couly@insa-rouen.fr, Harari, Marine¹ marine.harari@etu.univ-rouen.fr, Dubouilh-Benard, Carole¹ carole.dubouilh@univ-rouen.fr, Bailly, Laetitia¹ laetitia.bailly@insa-rouen.fr, Petit, Emilie¹ emilie.petit@insa-rouen.fr, Diharce, Julien² julien.diharce@univ-orleans.fr, Bonnet, Pascal² pascal.bonnet@univ-orleans.fr, Meijer, Laurent³ meijer@manros-therapeutics.com, Fruit, Corinne¹ corinne.fruit@univ-rouen.fr, Besson, Thierry¹ thierry.besson@univ-rouen.fr

Publikováno v: Molecules. Sep2018, Vol. 23 Issue 9, p2181. 16p. 13 Diagrams, 4 Charts.

Late-Stage Sequential C-H Functionalization of Thiazolo[5,4-f]quina-zolin-9(8H)-one: Synthesis of a Library of Potential Kinase Inhibitors

Autor: Fruit, Corinne, Couly, Florence, Harari, Marine, Levacher, Vincent, Besson, Thierry

Publikováno v: International Electronic Conference on Synthetic Organic Chemistry (ECSOC, 20, 2016)
International Electronic Conference on Synthetic Organic Chemistry (ECSOC, 20, 2016), Julio A. Seijas Vázquez (coord.), Nov 2016, [online], Spain

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c5bc80e30999c467357bb45cf6d2279
https://hal-normandie-univ.archives-ouvertes.fr/hal-02383920

Ligand-free Pd/Cu-catalyzed microwave-assisted C-H arylation of quinazolin-4(3H)-ones with aryl iodides

Autor: Harari, Marine, Fruit, Corinne, Besson, Thierry

Publikováno v: Semaine d'études en chimie organique (SECO, 52, 2015)
Semaine d'études en chimie organique (SECO, 52, 2015), May 2015, Morzine, France

National audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64f7d47bdcbcb42548cb6c2e43e35232
https://hal-normandie-univ.archives-ouvertes.fr/hal-02378695

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