Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

Autor: Marenholz, Ingo, Grosche, Sarah, Kalb, Birgit, Rüschendorf, Franz, Blümchen, Katharina, Schlags, Rupert, Harandi, Neda, Price, Mareike, Hansen, Gesine, Seidenberg, Jürgen, Röblitz, Holger, Yürek, Songül, Tschirner, Sebastian, Hong, Xiumei, Wang, Xiaobin, Homuth, Georg, Schmidt, Carsten, Nöthen, Markus Maria, Hübner, Norbert, Niggemann, Bodo, Beyer, Kirsten, Lee, Young-Ae

Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food chall

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http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46966

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.

Autor: Marenholz I; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, 13125, Berlin, Germany., Grosche S; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, 13125, Berlin, Germany., Kalb B; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, 13125, Berlin, Germany.; Department of Pediatric Pneumology and Immunology, Charité University Medical Center, 13353, Berlin, Germany., Rüschendorf F; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany., Blümchen K; Department of Allergy, Pulmonology and Cystic Fibrosis, Children's Hospital, Goethe University, 60590, Frankfurt am Main, Germany., Schlags R; Department of Pediatric Pneumology and Allergology, Wangen Hospital, 88239, Wangen, Germany., Harandi N; Department of Pediatric Pneumology and Allergology, Wangen Hospital, 88239, Wangen, Germany., Price M; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625, Hannover, Germany., Hansen G; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625, Hannover, Germany., Seidenberg J; Department of Pediatric Pneumology and Allergology, Neonatology and Intensive Care, Medical Campus of University Oldenburg, 26133, Oldenburg, Germany., Röblitz H; Department of Pediatrics and Adolescent Medicine, Sana Klinikum Lichtenberg, 10365, Berlin, Germany., Yürek S; Department of Pediatric Pneumology and Immunology, Charité University Medical Center, 13353, Berlin, Germany., Tschirner S; Department of Pediatric Pneumology and Immunology, Charité University Medical Center, 13353, Berlin, Germany., Hong X; Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Wang X; Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, 17487, Greifswald, Germany., Schmidt CO; Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, 17475, Greifswald, Germany., Nöthen MM; Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, 53127, Bonn, Germany., Hübner N; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany., Niggemann B; Department of Pediatric Pneumology and Immunology, Charité University Medical Center, 13353, Berlin, Germany., Beyer K; Department of Pediatric Pneumology and Immunology, Charité University Medical Center, 13353, Berlin, Germany., Lee YA; Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany. yolee@mdc-berlin.de.; Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, 13125, Berlin, Germany. yolee@mdc-berlin.de.

Publikováno v: Nature communications [Nat Commun] 2017 Oct 20; Vol. 8 (1), pp. 1056. Date of Electronic Publication: 2017 Oct 20.