Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Harald Steiner"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid precursor protein (APP) involved in Alzheimer’s disease pathology and other transmembrane proteins. Substrate-bound structures reveal a stable hybrid β-sheet imme
Externí odkaz:
https://doaj.org/article/48b0616409a4499db90dfcc202d4e365
Autor:
Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Deuterium/hydrogen exchange shows that conformational flexibility of the hybrid transmembrane domains (TMD) of amyloid precursor proteins plays a role in TMD cleavability by γ-secretase in vitro and in cellulo.
Externí odkaz:
https://doaj.org/article/f8c5876c1e1f44b2bcdc3ca0c114697b
Autor:
Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp n/a-n/a (2022)
Abstract Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly unders
Externí odkaz:
https://doaj.org/article/9be7449636e44c638a2a638ecfb8a4fe
Autor:
Lukas P Feilen, Shu-Yu Chen, Akio Fukumori, Regina Feederle, Martin Zacharias, Harald Steiner
Publikováno v:
eLife, Vol 11 (2022)
Cleavage of membrane proteins in the lipid bilayer by intramembrane proteases is crucial for health and disease. Although different lipid environments can potently modulate their activity, how this is linked to their structural dynamics is unclear. H
Externí odkaz:
https://doaj.org/article/7c5c5d512e374ee1acce648e2de1a369
Autor:
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Publikováno v:
eLife, Vol 10 (2021)
Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown. Here, we identify microbiota-derived short
Externí odkaz:
https://doaj.org/article/f7e1c8681be24568b1770df48198e501
Publikováno v:
Cell Stress, Vol 2, Iss 11, Pp 292-310 (2018)
Alzheimer´s disease (AD) is a devastating neurodegenerative disease of the elderly population. Genetic evidence strongly suggests that aberrant generation and/or clearance of the neurotoxic amyloid-β peptide (Aβ) is triggering the disease. Aβ is
Externí odkaz:
https://doaj.org/article/bd8bb33a54fc4af8b1529494f54a32b6
Autor:
Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner, Evamarie Hey-Hawkins
Publikováno v:
Molecules, Vol 26, Iss 10, p 2843 (2021)
All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyl
Externí odkaz:
https://doaj.org/article/9537748cb2df47b69a4f40088f5e7794
Autor:
Julia Junker, Isabelle Chong, Frits Kamp, Harald Steiner, Martin Giera, Christoph Müller, Franz Bracher
Publikováno v:
Molecules, Vol 24, Iss 13, p 2353 (2019)
Sulfoconjugates of sterols play important roles as neurosteroids, neurotransmitters, and ion channel ligands in health and disease. In most cases, sterol conjugate analysis is performed with liquid chromatography-mass spectrometry. This is a valuable
Externí odkaz:
https://doaj.org/article/88ab6d7270e047418cccca13eda73096
Autor:
Thomas Glatzl, Roman Beigelbeck, Samir Cerimovic, Harald Steiner, Florian Wenig, Thilo Sauter, Albert Treytl, Franz Keplinger
Publikováno v:
Sensors, Vol 19, Iss 5, p 1065 (2019)
We present a thermal flow sensor designed for measuring air as well as water flow velocities in heating, ventilation, and air conditioning (HVAC) systems. The sensor is designed to integrate the flow along the entire diameter of the pipe also quantif
Externí odkaz:
https://doaj.org/article/c2a3c8311a7f4727bc1d7e596b9148df
Autor:
Matthias Kahr, Michael Stifter, Harald Steiner, Wilfried Hortschitz, Gabor Kovács, Andreas Kainz, Johannes Schalko, Franz Keplinger
Publikováno v:
Sensors, Vol 19, Iss 3, p 493 (2019)
Accurate knowledge of the spatial magnetic field distribution is necessary when measuring field gradients. Therefore, a MEMS magnetic field gradiometer is reported, consisting of two identical, but independent laterally oscillating masses on a single
Externí odkaz:
https://doaj.org/article/d4da236c3d4946f5a38212528baaa15c