Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Harald Scheuch"'
Autor:
Juan Guinea-Viniegra, Erwin F. Wagner, Rainer Zenz, Maria Jimenez, Peter Petzelbauer, Harald Scheuch, Latifa Bakiri
Publikováno v:
Journal of Clinical Investigation. 122:2898-2910
Squamous cell carcinomas (SCCs) are heterogeneous and aggressive skin tumors for which innovative, targeted therapies are needed. Here, we identify a p53/TACE pathway that is negatively regulated by FOS and show that the FOS/p53/TACE axis suppresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf42c4d811f29552b389c9cecef308b3
https://doi.org/10.1172/jci63103
https://doi.org/10.1172/jci63103
Autor:
Juan Guinea-Viniegra, Helia B. Schonthaler, Maria Sibilia, Latifa Bakiri, Harald Scheuch, Erwin F. Wagner, Denes Hnisz, Martin Holcmann, Rainer Zenz
Publikováno v:
Genes & Development. 23:2663-2674
Inducible epidermal deletion ofJunBandc-Junin adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNFα play a major role in this phenotype. Here we define the underlying molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286cb1df55cdb343d171f3007176ea45
https://doi.org/10.1101/gad.543109
https://doi.org/10.1101/gad.543109
Autor:
Lukas Kenner, Helia B. Schonthaler, Harald Scheuch, Erwin F. Wagner, Rainer Zenz, Josef M. Penninger, Arabella Meixner
Publikováno v:
Nature Cell Biology. 10:1003-1011
Mice that lack JunB in epidermal cells are born with normal skin; however, keratinocytes hyperproliferate in vitro and on TPA treatment in vivo. Loss of JunB expression in the epidermis of adult mice affects the skin, the proliferation of haematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd0c49d48d901dff8cae8deaabf40f7
https://doi.org/10.1038/ncb1761
https://doi.org/10.1038/ncb1761
Autor:
Niamh Keon, Astrid Hoebertz, Marina Schorpp-Kistner, Peter Angel, Florian A. Karreth, Robert Eferl, Lukas Kenner, Erwin F. Wagner, F. Timo Beil, Agnieszka P. Szremska, Harald Scheuch, Michael Amling
Publikováno v:
The Journal of Cell Biology
Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunBDelta/Delta mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb687591d1a2184cf1f8e595b4bf9dec
https://doi.org/10.1083/jcb.200308155
https://doi.org/10.1083/jcb.200308155
Autor:
Erwin F. Wagner, Maria Sibilia, Carsten Frank, Paul Martin, Harald Scheuch, Lukas Kenner, Robert Eferl, Rainer Zenz
Publikováno v:
Developmental Cell. 4(6):879-889
To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7797d3e9f8409645d268dff8916f7ff0
Autor:
Latifa Bakiri, Kurt Zatloukal, Xiaotao Chen, Erwin F. Wagner, Zhixin Qiu, Lijian Hui, Harald Scheuch, Lun-Xiu Qin, Yuan Ji, Lihua Min, Hai Zheng, Lingli Chen, Jin Cen
Publikováno v:
Nature Cell Biology
Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation remain elusive, largely owing to a lack of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b09c3644a43ea9340e6b6c2b9eab67d
Autor:
Astrid Hoebertz, Latifa Bakiri, Colin L. Stewart, Erwin F. Wagner, Vukoslav Komnenovic, Michael Amling, Aline Bozec, Matthias Priemel, Robert Eferl, Arndt F. Schilling, Harald Scheuch
Publikováno v:
Nature. 454(7201)
Osteoclasts are cells that resorb bone. Too many of them, and osteoporosis — a common metabolic disorder of the skeleton — can result, as well as several other diseases. Although the protein c-Fos plays an essential part in the formation of osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430dda587cfad8f2bad58134fc36ca47
https://pubmed.ncbi.nlm.nih.gov/18548006
https://pubmed.ncbi.nlm.nih.gov/18548006
Autor:
Andreas Mairhorfer, Latifa Bakiri, Lukas Kenner, Norbert Schweifer, Vukoslav Komnenovic, Christian Haslinger, Lijian Hui, Erwin F. Wagner, Hartmut Beug, Harald Scheuch
Publikováno v:
Nature genetics. 39(6)
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional Mapk14 (also known as p38alpha) alleles, we investigated its function in postnatal development and tumorigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8245f1202d37ec95d2f814eaf156e1ef
https://pubmed.ncbi.nlm.nih.gov/17468757
https://pubmed.ncbi.nlm.nih.gov/17468757
Autor:
Denis Mehic, Erwin F. Wagner, Peter Angel, Lore Florin, Erwin Tschachler, Lars Hummerich, Lukas Kenner, Robert Eferl, Harald Scheuch, Rainer Zenz
Publikováno v:
Nature. 437(7057)
Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity. Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression of JunB, a gene localized in the psoriasis susceptibility region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8b9c7279125abd9e61f90086b0701c
https://pubmed.ncbi.nlm.nih.gov/16163348
https://pubmed.ncbi.nlm.nih.gov/16163348
Publikováno v:
Development (Cambridge, England). 131(22)
The Fos-related AP1 transcription factor Fra2 (encoded by Fosl2)is expressed in various epithelial cells as well as in cartilaginous structures. We studied the role of Fra2 in cartilage development. The absence of Fra2 in embryos and newborns leads t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a09b1720116135c1e86223a74998b0
https://pubmed.ncbi.nlm.nih.gov/15509771
https://pubmed.ncbi.nlm.nih.gov/15509771