Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Harald Oey"'
Autor:
Andres Tapia del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D. Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey Breslin, Harald Oey, Yvonne D. Krom, Dinja van der Hoorn, Linde F. Bouwman, Timothy M. Johanson, Matthew E. Ritchie, Quentin A. Gouil, Bruno Reversade, Fabrice Prin, Timothy Mohun, Silvère M. van der Maarel, Edwina McGlinn, James M. Murphy, Andrew Keniry, Jessica C. de Greef, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity at endogenous developmental ta
Externí odkaz:
https://doaj.org/article/4b268abe87144921872eecf80d018c13
Autor:
Ankit Shukla, Thu H. M. Nguyen, Sarat B. Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause, Eloise Dray, J. Lynn Fink, Pascal H. G. Duijf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and r
Externí odkaz:
https://doaj.org/article/0e49d0a39fa34863b24fe89eadb7f3d8
Autor:
Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D Young, Pasi K Korhonen, Geoffrey N Gobert, Sujeevi Nawaratna, Shihab Hasan, David M Martínez, Hong You, Martin Lavin, Malcolm K Jones, Mark A Ragan, Jens Stoye, Ana Oleaga, Aidan M Emery, Bonnie L Webster, David Rollinson, Robin B Gasser, Donald P McManus, Lutz Krause
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007513 (2019)
Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the hum
Externí odkaz:
https://doaj.org/article/ba05c4adcb15424eba9c8beaec1c0abb
Autor:
Luke Isbel, Lexie Prokopuk, Haoyu Wu, Lucia Daxinger, Harald Oey, Alex Spurling, Adam J Lawther, Matthew W Hale, Emma Whitelaw
Publikováno v:
eLife, Vol 5 (2016)
We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor. Here, we provide evidence that it may also function as a transcriptional acti
Externí odkaz:
https://doaj.org/article/91bbae90d51a4662991b315892311129
Autor:
Luke Isbel, Rahul Srivastava, Harald Oey, Alex Spurling, Lucia Daxinger, Hamsa Puthalakath, Emma Whitelaw
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005693 (2015)
Transposable elements (TEs) have been active in the mammalian genome for millions of years and the silencing of these elements in the germline is important for the survival of the host. Mice carrying reporter transgenes can be used to model transcrip
Externí odkaz:
https://doaj.org/article/fd2bcc69f19e41998f8ee1ed8b457ae2
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techniques are ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f97b1240044fb8b2cbde3e678fa16bff
https://doi.org/10.1158/1541-7786.c.6545076.v1
https://doi.org/10.1158/1541-7786.c.6545076.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Kaplan-Meier (log-rank) analysis of MPP4 and SD3 showing the PFS and OS for stage III patients only. a. PFS for MPP4, **p=0.0017, b. OS for MPP4, *p=0.0117, c. PFS for SD3, ***p=0.0003 and d. OS for SD3, **p=0.0094.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f040cccdef8feb541b68139b6f71b5
https://doi.org/10.1158/1541-7786.22526397
https://doi.org/10.1158/1541-7786.22526397
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Multiplex immunofluorescence staining quantification by Visiopharm Image Analytical System. DAPI nuclei were segmented defining the areas. Then each marker was quantified within this DAPI area. MPP4 low (MelR062) and MPP4 high (MelR166) phenotypes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7146eeafe20b948699b45e4ce745c2ec
https://doi.org/10.1158/1541-7786.22526391.v1
https://doi.org/10.1158/1541-7786.22526391.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
Table S1. Patient Characteristics. AJCC: American Joint Committee on Cancer Table S2. Clinical information including histology, stage and survival. Table S3. Univariate analysis of clinico-pathological and CT features. Log-rank (Mantel-Cox) test to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e238e944f47b1f9a7e90210ae6a21a80
https://doi.org/10.1158/1541-7786.22526388.v1
https://doi.org/10.1158/1541-7786.22526388.v1
Autor:
Andrew P. Barbour, Kenneth Miles, Nicola Waddell, B. Mark Smithers, Samuel Yang, Gerard Bayley, Geoffrey Strutton, Phillip Law, Victoria Atkinson, Conor J. Bloxham, Julia J. Bradford, Kalpana Patel, Harald Oey, John V. Pearson, Marjan M. Naeini, Lambros T. Koufariotis, Shaun B. Walters, Sandra Brosda, Vanessa F. Bonazzi, Bernadette Z.Y. Wong, Lauren G. Aoude
The association between TMB and SD3/MPP4 is not statistically significant. A. MPP4, not significant, Fisher's exact. B. SD3, not significant, Fisher's exact.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c83c28f7b9da633dc18a4e63a7475fb
https://doi.org/10.1158/1541-7786.22526394.v1
https://doi.org/10.1158/1541-7786.22526394.v1