Výsledky vyhledávání - "Harald M. H. G. Albers"

Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis

Autor: Shin Fukuda, Masayuki Miyasaka, Waka Yokoyama, Masahiro Jona, Yutaka Yatomi, Chie Miyabe, Yoshiko Iwai, Toshihiro Nanki, Hiroshi Ueda, Harald M. H. G. Albers, Ryunosuke Ohkawa, Nobuyuki Miyasaka, Yasunori Tokuhara, Junken Aoki, Aiko Takayasu, Yoshishige Miyabe, Jerold Chun, Huib Ovaa, Jun Nagai

Publikováno v: Arthritis & Rheumatism. 65:2037-2047

Objective Lysophosphatidic acid (LPA) is a bioactive lipid that binds to a group of cell surface G protein–coupled receptors (LPA receptors 1–6 [LPA1–6]) and has been implicated as an important mediator of angiogenesis, inflammation, and cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b759a493b519ac06985c605c60b2c1e
https://doi.org/10.1002/art.37991

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Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish

Autor: Harald M. H. G. Albers, Anna J. S. Houben, Ku-Chi Tsao, Shih-Lei Lai, Huib Ovaa, Wan-Ling Yao, Shyh-Jye Lee, Wouter H. Moolenaar

Publikováno v: Development. 139:4439-4448

Left-right (L-R) patterning is essential for proper organ morphogenesis and function. Calcium fluxes in dorsal forerunner cells (DFCs) are known to regulate the formation of Kupffer's vesicle (KV), a central organ for establishing L-R asymmetry in ze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b46bef522d603a4cd6a51708bb9b40
https://doi.org/10.1242/dev.081745

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Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice

Autor: Susan S. Smyth, Hongmei Ren, Eric M. Blalock, Paul Mueller, Lorenzo Federico, Manjula Sunkara, Tao Wu, Huib Ovaa, Shuying Liu, Andrew J. Morris, Harald M. H. G. Albers, Gordon B. Mills, Jelena Popovic

Publikováno v: Molecular Endocrinology. 26:786-797

Brown adipose tissue is a thermogenic organ that dissipates stored energy as heat to maintain body temperature. This process may also provide protection from development of diet-induced obesity. We report that the bioactive lipid mediator lysophospha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::028922708b73e50a148b3d7820fed114
https://doi.org/10.1210/me.2011-1229

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Chemical Evolution of Autotaxin Inhibitors

Autor: Harald M. H. G. Albers, Huib Ovaa

Publikováno v: Chemical Reviews

In 1992, autotaxin (ATX or ENPP2) was isolated as an autocrine motility factor from melanoma cells.1 The ∼120 kDa glycoprotein ATX belongs to a small family named ectonucleotide pyrophosphatase and phosphodiesterase (ENPP), which consists of seven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21051bcb25d37864b1a39ccd5f5a646d
https://doi.org/10.1021/cr2003213

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Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin

Autor: Harald M. H. G. Albers, Anastassis Perrakis, Huib Ovaa, Jens Hausmann, Loes Hendrickx, Rob J. P. van Tol

Publikováno v: Journal of Medicinal Chemistry

Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83c2b9b908e9111f4041e284e640b2f
http://europepmc.org/articles/PMC3131786

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Controlled Supramolecular Oligomerization of C3-Symmetrical Molecules in Water: The Impact of Hydrophobic Shielding

Autor: Pol Besenius, Nico A. J. M. Sommerdijk, Anja R. A. Palmans, E. W. Meijer, Kelly P. van den Hout, Tom F. A. de Greef, Thomas M. Hermans, Bas F. M. de Waal, Luuk L. C. Olijve, Harald M. H. G. Albers, Paul H. H. Bomans, Giuseppe Portale, Marcel H. P. van Genderen, Jef A. J. M. Vekemans

Publikováno v: Chemistry : A European Journal, 17(18), 5193-5203. Wiley-VCH Verlag

The supramolecular oligomerization of three water-soluble C(3)-symmetrical discotic molecules is reported. The compounds all possess benzene-1,3,5-tricarboxamide cores and peripheral Gd(III)-DTPA (diethylene triamine pentaacetic acid) moieties, but d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027f18a2211951da03211587dd26583a
https://doi.org/10.1002/chem.201002976

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Structural basis of substrate discrimination and integrin binding by autotaxin

Publikováno v: Nature Structural & Molecular Biology. 18:198-204

Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0127ea71e1de23fd487334a953f7a46
https://doi.org/10.1038/nsmb.1980

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Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin

Autor: Laurens A. van Meeteren, Wouter H. Moolenaar, Erica W. van Tilburg, David A. Egan, Huib Ovaa, Harald M. H. G. Albers

Publikováno v: Journal of Medicinal Chemistry. 53:4958-4967

Autotaxin (ATX) is an extracellular enzyme that hydrolyzes lysophosphatidylcholine (LPC) to produce the lipid mediator lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in diverse physiological and pathological processes, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaee5e49143fc50120a27acbd325c35c
https://doi.org/10.1021/jm1005012

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Integrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infection

Autor: Nora Liu, Tiziana Scanu, Harald M. H. G. Albers, Jacques Neefjes, Nadha Farhou, Coenraad Kuijl, Sharida Wekker, Bernat Blasco-Moreno, Jeroen Bakker, Loes Hendrickx, Patrick H.N. Celie, Jeroen den Hertog, Huib Ovaa

Publikováno v: ACS Chemical Biology
Nature Chemical Biology, 9(2), 414-22. Nature Publishing Group

Every year three million people die as a result of bacterial infections, and this number may further increase due to resistance to current antibiotics. These antibiotics target almost all essential bacterial processes, leaving only a few new targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdec530f2a291104817c2f5a3839e445
https://pubmed.ncbi.nlm.nih.gov/24274083

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Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis

Autor: Zhongbin Bai, Yutaka Komai, Makoto Suematsu, Linjun Cai, Akira Takeda, Shinichi Okudaira, Yuki Sugiura, Harald M. H. G. Albers, Kazuo Tohya, Huib Ovaa, Masayuki Miyasaka, Erina Hata, Akiko Kubo, Haruko Hayasaka, Punniyakoti T. Veeraveedu, Toshiyuki Tanaka, Eiji Umemoto, Junken Aoki

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(5)

Lymphocyte extravasation from the high endothelial venules (HEVs) of lymph nodes is crucial for the maintenance of immune homeostasis, but its molecular mechanism remains largely unknown. In this article, we report that lymphocyte transmigration acro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab56e617d05d9867b7f3e118f0423fc
https://pubmed.ncbi.nlm.nih.gov/23365076

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