Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Harald M I Kerkkamp"'
Autor:
Freek J Vonk, Mátyás A Bittenbinder, Harald M I Kerkkamp, Dwin G B Grashof, John P Archer, Sandra Afonso, Michael K Richardson, Jeroen Kool, Arie van der Meijden
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0258712 (2021)
Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline. Transcriptomes are important tools for st
Externí odkaz:
https://doaj.org/article/9647148e57444214ad232b3792d6f47b
Autor:
Dwin G. B. Grashof, Harald M. I. Kerkkamp, Sandra Afonso, John Archer, D. James Harris, Michael K. Richardson, Freek J. Vonk, Arie van der Meijden
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Venom has evolved in parallel in multiple animals for the purpose of self-defense, prey capture or both. These venoms typically consist of highly complex mixtures of toxins: diverse bioactive peptides and/or proteins each with a s
Externí odkaz:
https://doaj.org/article/c2af4c37f1e740489f1e7a6d8307fda7
Autor:
Nicholas R. Casewell, Mátyás A. Bittenbinder, Hans Clevers, Harald M. I. Kerkkamp, Jens Puschhof, Yorick Post, Freek J. Vonk, Joep Beumer, Michael K. Richardson
Publikováno v:
Nature Protocols, 16(3), 1494-1510. Nature Publishing Group
Puschhof, J, Post, Y, Beumer, J, Kerkkamp, H M, Bittenbinder, M, Vonk, F J, Casewell, N R, Richardson, M K & Clevers, H 2021, ' Derivation of snake venom gland organoids for in vitro venom production ', Nature Protocols, vol. 16, no. 3, pp. 1494-1510 . https://doi.org/10.1038/s41596-020-00463-4
Puschhof, J, Post, Y, Beumer, J, Kerkkamp, H M, Bittenbinder, M, Vonk, F J, Casewell, N R, Richardson, M K & Clevers, H 2021, ' Derivation of snake venom gland organoids for in vitro venom production ', Nature Protocols, vol. 16, no. 3, pp. 1494-1510 . https://doi.org/10.1038/s41596-020-00463-4
More than 400,000 people each year suffer adverse effects following bites from venomous snakes. However, snake venom is also a rich source of bioactive molecules with known or potential therapeutic applications. Manually ‘milking’ snakes is the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd30f8baead05384455572a94b2aa20
http://www.scopus.com/inward/record.url?scp=85099969454&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85099969454&partnerID=8YFLogxK
Autor:
Nicholas R. Casewell, Christiaan V. Henkel, Freek J. Vonk, Sonja Meimann, Kate L. Sanders, David J. Gower, James F. Fleming, Leo Peichl, Bruno F. Simões, Davide Pisani, Harald M. I. Kerkkamp, Michael K. Richardson
Publikováno v:
Gower, D J, Fleming, J, Pisani, D, Vonk, F, Kerkkamp, H, Peichl, L, Neumann, S, Casewell, N, Henkel, C, Richardson, M, Sanders, K & Simões, B 2021, ' Eye-transcriptome and genome-wide sequencing for Scolecophidia: implications for inferring the visual system fo the ancestral snake ', Genome Biology and Evolution, vol. 13, no. 12, evab253 . https://doi.org/10.1093/gbe/evab253
Genome Biology and Evolution
Genome Biology and Evolution
Molecular genetic data have recently been incorporated in attempts to reconstruct the ecology of the ancestral snake, though this has been limited by a paucity of data for one of the two main extant snake taxa, the highly fossorial Scolecophidia. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f96a5b3467e154fbf800e24f68816a0
https://hdl.handle.net/1983/0d14758d-e236-4c5c-949a-e1d903e1c798
https://hdl.handle.net/1983/0d14758d-e236-4c5c-949a-e1d903e1c798
Autor:
Harald M. I. Kerkkamp, R. Manjunatha Kini, Alexey S. Pospelov, Freek J. Vonk, Christiaan V. Henkel, Michael K. Richardson
Publikováno v:
Toxins, Vol 8, Iss 12, p 360 (2016)
Snake genome sequencing is in its infancy—very much behind the progress made in sequencing the genomes of humans, model organisms and pathogens relevant to biomedical research, and agricultural species. We provide here an overview of some of the sn
Externí odkaz:
https://doaj.org/article/a6d1b15abff4428ca43bb264f3f9ca89
Autor:
Harald M. I. Kerkkamp, Muzaffar Ali Khan, Michael K. Richardson, Bryan G. Fry, Merijn A. G. de Bakker
Publikováno v:
Toxicon. 177:S37-S38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e82e1c2d46967ab1ac01109a3e14d0cf
https://doi.org/10.1016/j.toxicon.2019.12.060
https://doi.org/10.1016/j.toxicon.2019.12.060
Autor:
Michael K. Richardson, Arie van der Meijden, Dwin G. B. Grashof, Sandra Afonso, Harald M. I. Kerkkamp, Freek J. Vonk, John Archer, D. James Harris
Publikováno v:
BMC Genomics
BMC Genomics, Vol 20, Iss 1, Pp 1-10 (2019)
BMC Genomics, Vol 20, Iss 1, Pp 1-10 (2019)
Background Venom has evolved in parallel in multiple animals for the purpose of self-defense, prey capture or both. These venoms typically consist of highly complex mixtures of toxins: diverse bioactive peptides and/or proteins each with a specific p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5254111862e9c9339c2d5e122d035da4
https://doi.org/10.1186/s12864-019-6013-6
https://doi.org/10.1186/s12864-019-6013-6
Autor:
Dušan Kordiš, Jawad Nazir, Roel Wouters, Michael K. Richardson, Bryan G. Fry, Bianca op den Brouw, R. Manjunatha Kini, Merijn A. G. de Bakker, Freek J. Vonk, Muzaffar Ali Khan, Harald M. I. Kerkkamp, Daniel Dashevsky, Jory van Thiel
Publikováno v:
Toxins
Volume 12
Issue 10
Khan, M A, Dashevsky, D, Kerkkamp, H, Kordiš, D, de Bakker, M A G, Wouters, R, van Thiel, J, op den Brouw, B, Vonk, F, Manjunatha Kini, R, Nazir, J, Fry, B G & Richardson, M K 2020, ' Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates ', Toxins, vol. 12, no. 10, 638, pp. 1-20 . https://doi.org/10.3390/toxins12100638
Toxins, 12(10), 638. MDPI
Toxins, Vol 12, Iss 638, p 638 (2020)
Toxins, 12(10):638, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 12
Issue 10
Khan, M A, Dashevsky, D, Kerkkamp, H, Kordiš, D, de Bakker, M A G, Wouters, R, van Thiel, J, op den Brouw, B, Vonk, F, Manjunatha Kini, R, Nazir, J, Fry, B G & Richardson, M K 2020, ' Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates ', Toxins, vol. 12, no. 10, 638, pp. 1-20 . https://doi.org/10.3390/toxins12100638
Toxins, 12(10), 638. MDPI
Toxins, Vol 12, Iss 638, p 638 (2020)
Toxins, 12(10):638, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous snakes have alpha-neurotoxins (&alpha
neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at th
neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02e1815136cd7ed10a179e0d8051b74
https://doi.org/10.3390/toxins12100638
https://doi.org/10.3390/toxins12100638
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 215
While it has been known for a while that some snake species are extremely sensitive to acetaminophen, the underlying mechanism for this toxicity has not been reported. To investigate if essential detoxification enzymes are missing in snake species th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5e52bd3142d3efb1f16a3dabda76ae
https://pubmed.ncbi.nlm.nih.gov/30268769
https://pubmed.ncbi.nlm.nih.gov/30268769
Autor:
Christoph P. Bagowski, Freek J. Vonk, Jeroen Kool, Harald M. I. Kerkkamp, Danielle H. Vlecken, Babette van Soolingen
Publikováno v:
Toxicon, 150, 39-49. Elsevier Limited
Kerkkamp, H, Bagowski, C, Kool, J, van Soolingen, B, Vonk, F J & Vlecken, D 2018, ' Whole snake venoms : Cytotoxic, anti-metastatic and antiangiogenic properties ', Toxicon, vol. 150, pp. 39-49 . https://doi.org/10.1016/j.toxicon.2018.05.004
Kerkkamp, H, Bagowski, C, Kool, J, van Soolingen, B, Vonk, F J & Vlecken, D 2018, ' Whole snake venoms : Cytotoxic, anti-metastatic and antiangiogenic properties ', Toxicon, vol. 150, pp. 39-49 . https://doi.org/10.1016/j.toxicon.2018.05.004
Currently, biological and organic substances are screened in order to find a new generation of therapeutics active against cancer. Previous research has identified promising candidate peptides in snake venom. In this study, venoms from different snak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff183a19d72ca8c5f90106e64a620973
https://research.vu.nl/en/publications/7d4d9924-11a9-4d39-a371-888bc8a6c14a
https://research.vu.nl/en/publications/7d4d9924-11a9-4d39-a371-888bc8a6c14a