Výsledky vyhledávání - "Harald Liedtke"

Bioresorbable Materials for Orthopedic Applications (Lactide and Glycolide Based)

Autor: Andrew Wood, Harald Liedtke, Mahrokh Dadsetan, Todd DeWitt, Balaji Prabhu, Andreas Karau

Publikováno v: Orthopedic Biomaterials ISBN: 9783319895413

A material capable of serving a purpose and then disappearing within the human body is no magic folklore but based on years of rigorous scientific evidence, proven clinical data, and wide commercial use. With over five decades of clinical use as mate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df906f67f10b483e890eedd89b26e3b6
https://doi.org/10.1007/978-3-319-89542-0_13

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β-Glucocerebrosidase: Affinity Purification and Characterization of its Active Site with N-Alkyl Derivatives of 1-Deoxynojirimycin

Autor: Harald Liedtke, Günter Legler

Publikováno v: Enzymes of Lipid Metabolism II ISBN: 9781468452143

An essential feature of the catalytic site of practically all β-glucosidases is a carboxylate group in close proximity to the glucosyl C-1 of the bound substrate. It participates in the bond breaking step by stabilizing a positive charge developing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4502780463f9c40495e4c5d89df16d
https://doi.org/10.1007/978-1-4684-5212-9_40

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Splenic Glucocerebrosidase and Its Cytosolic Activator Protein: Effects on Substrate Hydrolysis and Covalent Inhibition by Conduritol B Epoxides

Autor: Günter Legler, Harald Liedtke

Publikováno v: Lipid Storage Disorders ISBN: 9781461283003

β-Glucocerebrosidase, an enzyme associated with the lysosomal membrane, looses much of its activity during purification, especially if the procedure includes one or more delipidation steps (1). The activity could be restored by the additon of a cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfdfdba868a630a2eb65ad33dea2e051
https://doi.org/10.1007/978-1-4613-1029-7_43

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Glucosylceramidase from calf spleen. Characterization of its active site with 4-n-alkylumbelliferyl beta-glucosides and N-alkyl derivatives of 1-deoxynojirimycin

Autor: Günter Legler, Harald Liedtke

Publikováno v: Biological chemistry Hoppe-Seyler. 366(12)

The beta-glucosides of 4-heptyl-, -nonyl-, and -undecylumbelliferone were synthesized and their substrate properties studied with calf spleen glucosylceramidase. Self-association of the free long chain alkylumbelliferones in aqueous buffer was inferr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33666cb0fb5e548d9fd10fd5715747bb
https://pubmed.ncbi.nlm.nih.gov/2936366