Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Harald Labischinski"'
Autor:
Michael Kresken, Pamela Leow, Rainer Endermann, Barbara Körber-Irrgang, Will Stubbings, Falicia Goh, Goh Chee Yong, Harald Labischinski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:4394-4397
Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH
Publikováno v:
Journal of Antimicrobial Chemotherapy. 65:2530-2533
Objectives Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly acidic conditions (pH 5.0-6.5). The impact of individual and combinations of chromosomal mutations (gyrA, parC and marR)
Autor:
Michaele Josten, K. Gries, Tanja Schneider, S. Pelzer, Hans-Georg Sahl, Harald Labischinski, Imke Wiedemann
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1610-1618
Friulimicin B is a naturally occurring cyclic lipopeptide, produced by the actinomycete Actinoplanes friuliensis , with excellent activity against gram-positive pathogens, including multidrug-resistant strains. It consists of a macrocyclic decapeptid
Autor:
Aileen Rubio, Lois M. Ednie, Cynthia Whitener, Tatiana Bogdanovich, Kathleen G. Julian, Laura M. Koeth, Martin Roos, Harald Labischinski, Klaudia Kosowska-Shick, Peter C. Appelbaum, Leslie J. Parent
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3445-3448
We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O -acetyla
Autor:
Harald Labischinski, Jordi Benet-Buchholz, Dieter Habich, Veronica Hellwig, Andreas Schumacher, Heike Brötz-Oesterhelt, Rainer Endermann, Berthold Hinzen, Thomas Lampe, Holger Paulsen, Siegfried Raddatz
Publikováno v:
ChemMedChem. 1:689-693
Publikováno v:
Journal of Bacteriology. 187:2249-2256
Staphylococcus aureus is a widely distributed opportunistic pathogen that is often part of the normal flora of the upper respiratory tract, as well as the skin surface, of healthy individuals. Under opportune circumstances, however, S. aureus can cau
Publikováno v:
Mass Spectrometry Reviews. 24:549-565
Gene-expression profiling technologies in general, and proteomic technologies in particular have proven extremely useful to study the physiological response of bacterial cells to various environmental stress conditions. Complex protein toolkits coord
Autor:
Brian J. Wilkinson, Jennifer L. Koehl, Arunachalam Muthaiyan, Harald Labischinski, Radheshyam K. Jayaswal, Kerstin Ehlert
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:3749-3757
The cell wall composition and autolytic properties of passage-selected glycopeptide-intermediate Staphylococcus aureus (GISA) isolates and their parent strains were studied in order to investigate the mechanism of decreased vancomycin susceptibility.
Autor:
Thomas Lampe, Harald Labischinski, Karl Ziegelbauer, Ute Warnecke-Eberz, Igor Knezevic, Stephan Bartel, Dieter Habich, Heike Brötz-Oesterhelt
Publikováno v:
Journal of Biological Chemistry. 278:39435-39442
Pyridochromanones were identified by high throughput screening as potent inhibitors of NAD+-dependent DNA ligase from Escherichia coli. Further characterization revealed that eubacterial DNA ligases from Gram-negative and Gram-positive sources were i
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:948-955
We have used proteomic technology to elucidate the complex cellular responses of Bacillus subtilis to antimicrobial compounds belonging to classical and emerging antibiotic classes. We established on two-dimensional gels a comprehensive database of c