Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Harald Kranz"'
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Antibiotic-based plasmid selection and maintenance is a core tool in molecular biology; however, while convenient, this strategy has numerous drawbacks for biological manufacturing. Overuse of antibiotics and antibiotic resistance
Externí odkaz:
https://doaj.org/article/5e5632d23db5472a8140ecf2af420a87
Autor:
Manh Dat Hoang, Dieu Thi Doan, Marlen Schmidt, Harald Kranz, Andreas Kremling, Anna‐Lena Heins
Publikováno v:
Engineering in Life Sciences, Vol 23, Iss 1, Pp n/a-n/a (2023)
Abstract Biotechnological production processes are sustainable approaches for the production of biobased components such as amino acids for food and feed industry. Scale‐up from ideal lab‐scale bioreactors to large‐scale processes is often acco
Externí odkaz:
https://doaj.org/article/24e6696fad864c61b0cf5aad3175f460
Autor:
Mads E. Hauberg, Jordi Creus-Muncunill, Jaroslav Bendl, Alexey Kozlenkov, Biao Zeng, Chuhyon Corwin, Sarah Chowdhury, Harald Kranz, Yasmin L. Hurd, Michael Wegner, Anders D. Børglum, Stella Dracheva, Michelle E. Ehrlich, John F. Fullard, Panos Roussos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Here, the authors perform ATAC-seq on four distinct cell populations from three different regions of the human brain, finding that chromatin accessibility varies greatly by cell type and less by brain region. This study reveals differences in biologi
Externí odkaz:
https://doaj.org/article/91a74a493df14309930cea9170546613
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-20 (2020)
Abstract Background Today there is an increasing demand for high yielding robust and cost efficient biotechnological production processes. Although cells in these processes originate from isogenic cultures, heterogeneity induced by intrinsic and extr
Externí odkaz:
https://doaj.org/article/e56be849f982474383e1543620cfb34e
Autor:
Chiara Ambrogio, Patrick Stern, Claudio Scuoppo, Harald Kranz, Mariano Barbacid, David Santamaría
Publikováno v:
BioTechniques, Vol 57, Iss 4, Pp 179-187 (2014)
Despite the pressing need for novel cancer treatments, our improved understanding of tumor biology is not being successfully translated into better therapies. Here we present a lentiviral vector that enables in vivo validation of cancer therapeutic t
Externí odkaz:
https://doaj.org/article/19972bc6aa174747995a49196454c916
Publikováno v:
BioTechniques, Vol 46, Iss 7, Pp 527-533 (2009)
Existing methods for site-directed plasmid mutagenesis are restrained by the small spectrum of modifications that can be introduced by mutagenic primers and the amplicon size limitations of in vitro DNA synthesis. As demonstrated here, the combined u
Externí odkaz:
https://doaj.org/article/53ffce271cee4ebeaf803653581dab82
Publikováno v:
BioTechniques, Vol 45, Iss 3, Pp 335-337 (2008)
System-oriented applications of genetic engineering, such as metabolic engineering, often require the serial optimization of enzymatic reaction steps, which can be achieved by transcriptional fine-tuning. However, approaches to changing gene expressi
Externí odkaz:
https://doaj.org/article/0df0d975317242ac8c5edc9edd0102a4
Autor:
John P. McDonald, Roger Woodgate, Harald Kranz, Karolina Makiela-Dzbenska, Wei Yang, Erin Walsh, Dominic R. Quiros, Alexandra Vaisman, Marlen Schmidt, Krystian Łazowski, Martin A M Reijns, Kristiniana C Moreno
Publikováno v:
Molecular Microbiology
The Escherichia coli dnaE gene encodes the α‐catalytic subunit (pol IIIα) of DNA polymerase III, the cell’s main replicase. Like all high‐fidelity DNA polymerases, pol III possesses stringent base and sugar discrimination. The latter is media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18288e845950c22833c6713336082a7
https://doi.org/10.1111/mmi.14779
https://doi.org/10.1111/mmi.14779
Autor:
Manh Dat Hoang, Dieu Thi Doan, Marlen Schmidt, Harald Kranz, Andreas Kremling, Anna‐Lena Heins
Publikováno v:
Engineering in Life Sciences. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badca901844255e997efbe11a643df4f
https://doi.org/10.1002/elsc.202100162
https://doi.org/10.1002/elsc.202100162
Autor:
Manh Dat, Hoang, Dieu Thi, Doan, Marlen, Schmidt, Harald, Kranz, Andreas, Kremling, Anna-Lena, Heins
Publikováno v:
Engineering in life sciences. 23(1)
Biotechnological production processes are sustainable approaches for the production of biobased components such as amino acids for food and feed industry. Scale-up from ideal lab-scale bioreactors to large-scale processes is often accompanied by loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a520bfeec30a45eeb3c63c6fdf2b43e
https://pubmed.ncbi.nlm.nih.gov/36619877
https://pubmed.ncbi.nlm.nih.gov/36619877