Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Harald Janovjak"'
Autor:
Fangmin Zhou, Alexandra-Madelaine Tichy, Bibi Nusreen Imambocus, Shreyas Sakharwade, Francisco J. Rodriguez Jimenez, Marco González Martínez, Ishrat Jahan, Margarita Habib, Nina Wilhelmy, Vanessa Burre, Tatjana Lömker, Kathrin Sauter, Charlotte Helfrich-Förster, Jan Pielage, Ilona C. Grunwald Kadow, Harald Janovjak, Peter Soba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Neuromodulatory signaling via G protein-coupled receptors (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. The recent development of optogenetic tools to induce G protein-mediated signaling provides the
Externí odkaz:
https://doaj.org/article/1c2a5808f1fc4753ab1db2e542681121
Autor:
Harald Janovjak, Sonja Kleinlogel
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 7, Pp 1468-1470 (2022)
Externí odkaz:
https://doaj.org/article/bce8869e57314a07b2228df67099249e
Autor:
Alvaro Ingles-Prieto, Nikolas Furthmann, Samuel H Crossman, Alexandra-Madelaine Tichy, Nina Hoyer, Meike Petersen, Vanessa Zheden, Julia Biebl, Eva Reichhart, Attila Gyoergy, Daria E Siekhaus, Peter Soba, Konstanze F Winklhofer, Harald Janovjak
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009479 (2021)
Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are known to be
Externí odkaz:
https://doaj.org/article/4dfa5c91f4984c73a153ca31c9329c12
Publikováno v:
eLife, Vol 9 (2020)
Neuroligins (Nlgns) are adhesion proteins mediating trans-synaptic contacts in neurons. However, conflicting results around their role in synaptic differentiation arise from the various techniques used to manipulate Nlgn expression level. Orthogonall
Externí odkaz:
https://doaj.org/article/06757a4c3f5948ed870874ef97f9ef22
Autor:
Maurizio Morri, Inmaculada Sanchez-Romero, Alexandra-Madelaine Tichy, Stephanie Kainrath, Elliot J. Gerrard, Priscila P. Hirschfeld, Jan Schwarz, Harald Janovjak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptor
Externí odkaz:
https://doaj.org/article/6261fce9394843269dc20223e9a3d059
Autor:
Daniel Čapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg
Publikováno v:
eLife, Vol 8 (2019)
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tiss
Externí odkaz:
https://doaj.org/article/55294d5d287f45b0901b9d4d1dc4b696
Autor:
Keisuke Sako, Saurabh J. Pradhan, Vanessa Barone, Álvaro Inglés-Prieto, Patrick Müller, Verena Ruprecht, Daniel Čapek, Sanjeev Galande, Harald Janovjak, Carl-Philipp Heisenberg
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 866-877 (2016)
During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and time. Yet, tools for temporally controlling morphogen signaling within the embryo are still scarce. Here, we developed a photo
Externí odkaz:
https://doaj.org/article/844fc9840afe40f88c9c4914fbd0d71c
Optimized design andin vivoapplication of optogenetically functionalizedDrosophiladopamine receptors
Autor:
Fangmin Zhou, Alexandra-Madelaine Tichy, Bibi Nusreen Imambocus, Francisco J. Rodriguez Jimenez, Marco González Martínez, Ishrat Jahan, Margarita Habib, Nina Wilhelmy, Vanessa Bräuler, Tatjana Lömker, Kathrin Sauter, Charlotte Helfrich-Förster, Jan Pielage, Ilona C. Grunwald Kadow, Harald Janovjak, Peter Soba
Neuromodulatory signalingviaG protein-coupled receptor (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. Recent efforts have led to the development of optogenetic tools to induce G protein-mediated signaling, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb00cd4599bece55e141d1d17afdb00
https://doi.org/10.1101/2023.05.20.541404
https://doi.org/10.1101/2023.05.20.541404
Autor:
Christina G. Gangemi, Harald Janovjak
Optogenetic experiments rely on the controlled delivery of light to diverse biological systems. Impressive devices have been recently developed to simulate cells and small animals with multiple wavelengths and intensities. However, existing hardware
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8043b8ce03e1a8faf93bb886cc80a5
https://doi.org/10.21203/rs.3.rs-2801275/v1
https://doi.org/10.21203/rs.3.rs-2801275/v1
Autor:
Sarel J. Fleishman, Hiromu Monai, Björn Breithausen, Vanessa Vongsouthi, Leon Kremers, Joshua A. Mitchell, Christian Henneberger, Harald Janovjak, Petr Unichenko, Colin J. Jackson, Jason H. Whitfield, Hajime Hirase, Olga Khersonsky
Publikováno v:
ACS Sensors
ACS sensors 6(11), 4193-4205 (2021). doi:10.1021/acssensors.1c01803
ACS sensors 6(11), 4193-4205 (2021). doi:10.1021/acssensors.1c01803
Solute-binding proteins (SBPs) have evolved to balance the demands of ligand affinity, thermostability, and conformational change to accomplish diverse functions in small molecule transport, sensing, and chemotaxis. Although the ligand-induced confor