Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Harald J Maier"'
Autor:
Patrick Meyer, Pallab Maity, Andre Burkovski, Julian Schwab, Christoph Müssel, Karmveer Singh, Filipa F Ferreira, Linda Krug, Harald J Maier, Meinhard Wlaschek, Thomas Wirth, Hans A Kestler, Karin Scharffetter-Kochanek
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 12, p e1005741 (2017)
Cells and tissues are exposed to stress from numerous sources. Senescence is a protective mechanism that prevents malignant tissue changes and constitutes a fundamental mechanism of aging. It can be accompanied by a senescence associated secretory ph
Externí odkaz:
https://doaj.org/article/abba4c91a98545e68a452b8fcb3d2189
Autor:
Miltiadis Tsesmelis, Ulrike F. G. Büttner, Melanie Gerstenlauer, Uta Manfras, Konstantinos Tsesmelis, Ziwei Du, Nadine Sperb, Stephanie Ellen Weissinger, Peter Möller, Thomas F. E. Barth, Harald J. Maier, Lap Kwan Chan, Thomas Wirth
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is marked by a dismal survival rate, lacking effective therapeutics due to its aggressive growth, late-stage diagnosis, and chemotherapy resistance. Despite debates on NF-κB targeting for P
Externí odkaz:
https://doaj.org/article/d60de3829ea54fce943d4b1ee9fe0c20
Autor:
Bärbel Kraut, Harald J Maier, Enikö Kókai, Katja Fiedler, Thomas Boettger, Annett Illing, Sawa Kostin, Paul Walther, Thomas Braun, Thomas Wirth
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141591 (2015)
The transcription factor NF-κB has been associated with a range of pathological conditions of the heart, mainly based on its function as a master regulator of inflammation and pro-survival factor. Here, we addressed the question what effects activat
Externí odkaz:
https://doaj.org/article/65d575581c594ac5a03acc474eca1f39
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 1 (2023)
The emergence of cell and gene therapies has dramatically changed the treatment paradigm in oncology and other therapeutic areas. Kymriah® (tisagenlecleucel), a CD19-directed genetically modified autologous T-cell immunotherapy, is currently approve
Externí odkaz:
https://doaj.org/article/6d9d53c0d24f43cc9c57f66d36855706
Autor:
Stephan A. Grupp, Gabor Kari, Harald J. Maier, Karen Thudium Mueller, Edward R. Waldron, Kevin Nguyen, Creton Kalfoglou, Heather E. Stefanski, Jochen Buechner, Andre Baruchel, Peter Bader, G. Doug Myers, Tim Driscoll, Gregory A. Yanik, Hidefumi Hiramatsu, Michael W. Boyer, Susana Rives, Muna Qayed, Theodore W. Laetsch, Shannon L. Maude, Xia Han, Michael A. Pulsipher
Supplementary Data from Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f640dfe63ee4f38cc502810e22e2845
https://doi.org/10.1158/2643-3230.22544129
https://doi.org/10.1158/2643-3230.22544129
Autor:
Stephan A. Grupp, Gabor Kari, Harald J. Maier, Karen Thudium Mueller, Edward R. Waldron, Kevin Nguyen, Creton Kalfoglou, Heather E. Stefanski, Jochen Buechner, Andre Baruchel, Peter Bader, G. Doug Myers, Tim Driscoll, Gregory A. Yanik, Hidefumi Hiramatsu, Michael W. Boyer, Susana Rives, Muna Qayed, Theodore W. Laetsch, Shannon L. Maude, Xia Han, Michael A. Pulsipher
We assessed minimal residual disease (MRD) detection and B-cell aplasia after tisagenlecleucel therapy for acute lymphoblastic leukemia (ALL) to define biomarkers predictive of relapse (N = 143). Next-generation sequencing (NGS) MRD detection >0 in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a79c0ec9a1437e58820595e137dfe73
https://doi.org/10.1158/2643-3230.c.6550538.v1
https://doi.org/10.1158/2643-3230.c.6550538.v1
Autor:
Gabor Kari, André Baruchel, Hidefumi Hiramatsu, Peter Bader, Timothy A. Driscoll, Jochen Buechner, Muna Qayed, Kevin Nguyen, Xia Han, Shannon L. Maude, G. Doug Myers, Michael A. Pulsipher, Gregory A. Yanik, Stephan A. Grupp, Edward Waldron, Creton Kalfoglou, Karen Thudium Mueller, Susana Rives, Theodore W. Laetsch, Harald J. Maier, Michael Boyer, Heather E. Stefanski
Publikováno v:
Blood Cancer Discovery. 3:66-81
We assessed minimal residual disease (MRD) detection and B-cell aplasia after tisagenlecleucel therapy for acute lymphoblastic leukemia (ALL) to define biomarkers predictive of relapse (N = 143). Next-generation sequencing (NGS) MRD detection >0 in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff1144d9347b6b3fd0f7d0b27238f2db
https://doi.org/10.1158/2643-3230.bcd-21-0095
https://doi.org/10.1158/2643-3230.bcd-21-0095
Autor:
Miltiadis Tsesmelis, Lap Kwan Chan, Harald J. Maier, Frank Leithäuser, Melanie Gerstenlauer, Alexander Kleger, Thomas Wirth
Pancreatic stellate cells (PSCs) are resident cells in the exocrine pancreas which contribute to pancreatic fibrogenesis and inflammation. Studies on NF-κB in pancreatitis so far focused mainly on the parenchymal and myeloid compartments. Its functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4091a43dbea4f6fe0bd4279d724973e7
https://doi.org/10.21203/rs.3.rs-887736/v1
https://doi.org/10.21203/rs.3.rs-887736/v1
Autor:
Yoshiaki Sunami, Lena Erkert, Medhanie A. Mulaw, Umesh Tharehalli, Harald J. Maier, Thomas Wirth, Sarah Fischer, Thomas Seufferlein, Andrea Tannapfel, Sabine Heurich, Reinhold Schirmbeck, Sarah-Fee Katz, M. Svinarenko, André Lechel, Yuexin Chen
Publikováno v:
Cancers
Cancers, Vol 11, Iss 10, p 1410 (2019)
Volume 11
Issue 10
Cancers, Vol 11, Iss 10, p 1410 (2019)
Volume 11
Issue 10
Background: Most liver tumors arise on the basis of chronic liver diseases that trigger inflammatory responses. Besides inflammation, subsequent defects in the p53-signaling pathway frequently occurs in liver cancer. In this study, we analyzed the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a07b37fc4a2bbac57eee4fbc34f8cf4
http://europepmc.org/articles/PMC6827060
http://europepmc.org/articles/PMC6827060
Autor:
Frank Leithäuser, Matthew M. Yeh, Harald J. Maier, Melanie Gerstenlauer, Jiajia He, Lap Kwan Chan, Thomas Wirth
Publikováno v:
Cancer letters. 458
Primary liver cancer ranks among the leading causes of cancer death worldwide. Risk factors are closely linked to inflammation, such as viral hepatitis and alcoholic as well as non-alcoholic steatohepatitis. Among the pathways involved in the pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f4781c3c46e4ec2f6b5ebd4960306f
https://pubmed.ncbi.nlm.nih.gov/31128214
https://pubmed.ncbi.nlm.nih.gov/31128214