Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Harald Hirling"'
Autor:
Jean-Marc Brunner, Philippe Plattet, Marie-Agnès Doucey, Lia Rosso, Thomas Curie, Alexandra Montagner, Riccardo Wittek, Marc Vandelvelde, Andreas Zurbriggen, Harald Hirling, Béatrice Desvergne
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32803 (2012)
Although the pathology of Morbillivirus in the central nervous system (CNS) is well described, the molecular basis of neurodegenerative events still remains poorly understood. As a model to explore Morbillivirus-mediated CNS dysfunctions, we used can
Externí odkaz:
https://doaj.org/article/427fd4f08cbf4083b70e2e4ce895b44e
Autor:
Christel Genoud, Charles Quairiaux, Pascal Steiner, Harald Hirling, Egbert Welker, Graham W Knott
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e343 (2006)
Astrocytes play a major role in the removal of glutamate from the extracellular compartment. This clearance limits the glutamate receptor activation and affects the synaptic response. This function of the astrocyte is dependent on its positioning aro
Externí odkaz:
https://doaj.org/article/4a34e57cf7f44f52949fd70c3fb735d8
Autor:
Svend Davanger, Michel Kropf, O.P. Ottersen, Harald Hirling, Petter Laake, Finn Mogens Haug, Torgeir Holen, Jo Kristian Utvik, M.N. Mylonakou, Camilla Haglerød, Øivind Skare
Publikováno v:
Neuroscience. 158:96-104
Functional evidence suggests that neuronal enriched endosomal protein of 21 kDa (NEEP21) takes part in facilitating transport of AMPA receptors (AMPAR) in the synapse. To explore the anatomical basis for a role in this synaptic trafficking, we invest
Autor:
Johanna Generosi, Harald Hirling, Giorgio Margaritondo, Kai Johnsson, Norman Tolk, A. Cricenti, David W. Piston, Stefan Catsicas, Michel Kropf
Publikováno v:
physica status solidi c. 5:2641-2644
Infrared scanning near-field optical microscopy is used to detect AMPA-type glutamate receptor clusters in hippocampal neuron cells. AMPA's GluR2-subunits were marked with the fluorophore Alexa488 and high-resolution micrographs were taken at 6.25 µ
Autor:
Judith Klumperman, Harald Hirling, Johanna T. Cannon, Pekka Kujala, Zofia M. Lasiecka, Bettina Winckler, Dolora Wisco, Chan Choo Yap, Michael C. Chang
Publikováno v:
The Journal of Cell Biology
Correct targeting of proteins to axons and dendrites is crucial for neuronal function. We showed previously that axonal accumulation of the cell adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) depends on endocytosis (Wisco, D., E.D. A
Autor:
Paul Majcherczyk, Harald Hirling, Jean-Marc Brunner, Andreas Zurbriggen, Philippe Plattet, Riccardo Wittek
Publikováno v:
Journal of Neurochemistry. 103:1184-1195
The canine distemper virus (CDV) belongs to the Morbillivirus genus which includes important human pathogens like the closely related measles virus. CDV infection can reach the nervous system where it causes serious malfunctions. Although this pathol
Autor:
Frank Lafont, Stefan Catsicas, Sandor Kasas, Alexandre Yersin, Karina Kulangara, Charles Roduit, Giovanni Dietler, Pascal Steiner, Harald Hirling
Publikováno v:
Biophysical Journal. 92(12):4482-4489
Although various approaches are routinely used to study receptor trafficking, a technology that allows for visualizing trafficking of single receptors at the surface of living cells remains lacking. Here we used atomic force microscope to simultaneou
Autor:
Laura Saglietti, Maria Passafaro, Carlo Sala, Francesca Beretta, Harald Hirling, Morgan Sheng
Publikováno v:
Molecular and Cellular Neuroscience. 28:650-660
Here, we use a cell surface thrombin cleavage assay to investigate directly the role of NSF in the surface delivery and synaptic accumulation of alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors. In cultured hippocampal neurons, the
Autor:
X. Wang, Gabriele Grenningloh, László Forró, Alexandre Yersin, Giovanni Dietler, Harald Hirling, Romano Regazzi, Sandor Kasas, Stefan Catsicas, B. Huni, Beat M. Riederer, R. Marsault
Publikováno v:
Cell Motility and the Cytoskeleton. 62:124-132
The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is a highly dynamic supramolecular network actively involved in many essential biological mechanisms such as cellular structure, transport, movements, differenti
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279, pp.35687-35691
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279, pp.35687-35691
Recycling of endocytosed G-protein-coupled receptors involves a series of molecular events through early and recycling endosomes. The purpose of this work was to study the role of neuron-enriched endosomal protein of 21 kDa (NEEP21) in the recycling