Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Harald Hübner"'
Autor:
Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Background The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work reports the development of
Externí odkaz:
https://doaj.org/article/7220bee43e0941a9b4e53a8f1aa38dba
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine a
Externí odkaz:
https://doaj.org/article/06de6af761474c2b9a90d90838043ba7
Autor:
Jun Xu, Qinggong Wang, Harald Hübner, Yunfei Hu, Xiaogang Niu, Haoqing Wang, Shoji Maeda, Asuka Inoue, Yuyong Tao, Peter Gmeiner, Yang Du, Changwen Jin, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
Externí odkaz:
https://doaj.org/article/2a8a4fc6bad2451e913c4050e4dba574
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a33640b5b5bf4ee68a4f3543dfc0d68f
Autor:
Deborah Wenk, Vladimir Ignatchenko, Andrew Macklin, Harald Hübner, Peter Gmeiner, Dorothée Weikert, Monika Pischetsrieder, Thomas Kislinger
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The development of functionally selective or biased ligands is a promising approach towards drugs with less side effects. Biased ligands for G protein-coupled receptors can selectively induce G protein activation or β-arrestin recruitment.
Externí odkaz:
https://doaj.org/article/e7271728fe8049c8a10edf9dadf9f5a6
Autor:
Anni Allikalt, Nirupam Purkayastha, Khajidmaa Flad, Maximilian F. Schmidt, Alina Tabor, Peter Gmeiner, Harald Hübner, Dorothee Weikert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Fluorescent ligands are versatile tools for the study of G protein-coupled receptors. Depending on the fluorophore, they can be used for a range of different applications, including fluorescence microscopy and bioluminescence or fluorescence
Externí odkaz:
https://doaj.org/article/917ec5091e204abdb7245329c218d9c8
Autor:
Natascha Nebel, Brigitte Strauch, Simone Maschauer, Roman Lasch, Hannelore Rampp, Stefanie K. Fehler, Leonard R. Bock, Harald Hübner, Peter Gmeiner, Markus R. Heinrich, Olaf Prante
Publikováno v:
ACS Omega, Vol 2, Iss 12, Pp 8649-8659 (2017)
Externí odkaz:
https://doaj.org/article/3785002b6bdb43a5891c5df8f16ad311
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8647 (2021)
The human dopamine receptors D2S and D3 belong to the group of G protein-coupled receptors (GPCRs) and are important drug targets. Structural analyses and development of new receptor subtype specific drugs have been impeded by low expression yields o
Externí odkaz:
https://doaj.org/article/f583f29e869f4e3d8359052d7e4dfa50
Autor:
Xueke She, Andrea Pegoli, Judith Mayr, Harald Hübner, Günther Bernhardt, Peter Gmeiner, Max Keller
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 6741-6754 (2017)
Externí odkaz:
https://doaj.org/article/ccc71977ac8542fabfefb2480ed6e0de
Autor:
Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas Kaindl, Laurin Leeb, Timothy Clark, Dorothee Möller, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to the
Externí odkaz:
https://doaj.org/article/0157f3da6f7d40b3b16bfeb4284db320