Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study

Autor: Jan A Staessen, Ralph Wendt, Yu-Ling Yu, Sven Kalbitz, Lutgarde Thijs, Justyna Siwy, Julia Raad, Jochen Metzger, Barbara Neuhaus, Armin Papkalla, Heiko von der Leyen, Alexandre Mebazaa, Emmanuel Dudoignon, Goce Spasovski, Mimoza Milenkova, Aleksandra Canevska-Taneska, Mercedes Salgueira Lazo, Mina Psichogiou, Marek W Rajzer, Łukasz Fuławka, Magdalena Dzitkowska-Zabielska, Guenter Weiss, Torsten Feldt, Miriam Stegemann, Johan Normark, Alexander Zoufaly, Stefan Schmiedel, Michael Seilmaier, Benedikt Rumpf, Mirosław Banasik, Magdalena Krajewska, Lorenzo Catanese, Harald D Rupprecht, Beata Czerwieńska, Björn Peters, Åsa Nilsson, Katja Rothfuss, Christoph Lübbert, Harald Mischak, Joachim Beige, Lukasz Fulawka, Harald Rupprecht, Beata Czerwienska, Jörg Ermisch, Nils Kellner, Lydia Peruth-Stutzmann, Stefanie Schroth, Jonathan Schmidt, Ulrike Schmidt, Daniel Breuer, Fariza Abeud, Marie-Celine Fournier, Badr Louadah, Rocio Molas, Fraile Loreto Rojas, Fabiola Alonso García, Isabel Garcia Sánchez, Ioana Cezara Hrom, Andrzej Więczek., Matthias Schwab, Kei K Asayama, Tine W Hansen, Gladys E Maestre, Dimitrios Basoulis, Georgios Karamanakos., Pawel Lis, Agnieszka Olszanecka, Rosa Bellmann-Weiler, Lucas Lanser, Alicia Edin, Matthias NE Forsell, Bernd Stegmayr, Björn-Erik Ole Jensen, Hans-Martin Orth, Sylke Borstel, Agata Mikolajewska, Manfred Hecking, Lukas Schmölz, Michał Hoffmann, Krzysztof Narkiewicz, Agnieszka Matera-Witkiewicz, Justyna Zachciał, Monika Litwin, Patrycja Marciniak

BACKGROUND: The SARS-CoV-2 pandemic is a worldwide challenge. The CRIT-CoV-U pilot study generated a urinary proteomic biomarker consisting of 50 peptides (COV50), which predicted death and disease progression from SARS-CoV-2. After the interim analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3973ebe41317826f1bb3b476708a01e7
https://lirias.kuleuven.be/handle/20.500.12942/704971

A Novel Urinary Proteomics Classifier for Non-Invasive Evaluation of Interstitial Fibrosis and Tubular Atrophy in Chronic Kidney Disease

Autor: Joachim Beige, Emmanouil Mavrogeorgis, Harald D. Rupprecht, Justyna Siwy, Lorenzo Catanese, Kerstin Amann, Harald Mischak

Publikováno v: Proteomes
Volume 9
Issue 3
Proteomes, Vol 9, Iss 32, p 32 (2021)

Non-invasive urinary peptide biomarkers are able to detect and predict chronic kidney disease (CKD). Moreover, specific urinary peptides enable discrimination of different CKD etiologies and offer an interesting alternative to invasive kidney biopsy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d13164d9abf717bd99bc7d85448fbea

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

Autor: Harald D. Rupprecht, Philippe Schmitt-Kopplin, Marion Haubitz, Àngel Argilés, Michael Melter, Hartwig W. Bauer, Petra Zürbig, Mark Girolami, Mohammed Dakna, Anna F. Dominiczak, Lise Tarnow, Georg M. N. Behrens, Ziad A. Massy, Joshua J. Coon, Visith Thongboonkerd, Walter Kolch, Arnold Ganser, Holger Jahn, Karlheinz Peter, Raymond Vanholder, David M. Good, Volker Kliem, Jochen H. H. Ehrich, Eva M. Weissinger, Wilfried Gwinner, Kasper Rossing, Bruce A. Julian, George Jerums, Eric Schiffer, Christian Neusüss, Andrzej S. Krolewski, Jan Novak, Dan Theodorescu, Harald Mischak, Danilo Fliser, Jens-Uwe Stolzenburg, Christian Delles, Joost P. Schanstra, Igor Golovko, Mario Luppi, Stefan Herget-Rosenthal, Stéphane Decramer, Frank Eitner, Markus Kellmann, Joachim Jankowski, Moritz Frommberger

Publikováno v: Molecular & Cellular Proteomics
Mol. Cell. Proteomics 9, 2424-2437 (2010)
Molecular & Cellular Proteomics; Vol 9

Because of its availability, ease of collection, and correlation with physiology and pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack of comparable data sets from large cohorts has greatly hindered the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e92156c58df5b1e3feb78e887eae030

Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes

Autor: Hermann Haller, Danilo Fliser, Ronald Krebs, Eva M. Weissinger, Hartmut Hecker, Thorsten Kaiser, Sebastian Bartel, Stefan Wittke, Igor Golovko, Marion Haubitz, Harald Mischak, Harald D. Rupprecht

Publikováno v: Kidney International. 65:2426-2434

Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Background Proteomics applied in large scale may provide a useful diagnostic tool. Methods We developed an online combination of capillary el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59a3714fc8ccafd14015567278c27f8
https://doi.org/10.1111/j.1523-1755.2004.00659.x

Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis

Autor: Sven Weidner, Yoshitaka Isaka, Harald D. Rupprecht, Enyu Imai, Marina Carl, Yoshitaka Akagi

Publikováno v: Kidney International. 63(4):1302-1312

Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis. Background Mesangial cell proliferation is a frequent finding in glomerulonephritis. In cultured mesangial cells, we demonstrated that inhibition of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16133d9bb5de91cdc672451ebe3e0d7