Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Harald Braun"'
Autor:
Olga Krysko, Darya Korsakova, Andrea Teufelberger, Amse De Meyer, Jill Steels, Natalie De Ruyck, Judith van Ovost, Sharon Van Nevel, Gabriele Holtappels, Frauke Coppieters, Mikhail Ivanchenko, Harald Braun, Maria Vedunova, Dmitri V. Krysko, Claus Bachert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundRecent in vitro studies strongly implicated mast cell-derived proteases as regulators of IL-33 activity by enzymatic cleavage in its central domain. A better understanding of the role of mast cell proteases on IL-33 activity in vivo is need
Externí odkaz:
https://doaj.org/article/6dd9876d8f9f45ccb13d05891dad68e4
Autor:
Sharon Van Nevel, Judith van Ovost, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, Olga Krysko
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated wi
Externí odkaz:
https://doaj.org/article/8a2df2b4af6d4b32b91c39f9421dbabb
Autor:
Aurora Holgado, Harald Braun, Kenneth Verstraete, Domien Vanneste, Nico Callewaert, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease. Over the past years, a large number of biologics have been developed to target cytokines in disease,
Externí odkaz:
https://doaj.org/article/f958ab7e5e0c436db448efa534a4b2eb
Autor:
Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens, Savvas N. Savvides
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Teze
Externí odkaz:
https://doaj.org/article/acf43ca76ac74ec79666eaf28ea442d7
Autor:
Yunlong Yang, Patrik Andersson, Kayoko Hosaka, Yin Zhang, Renhai Cao, Hideki Iwamoto, Xiaojuan Yang, Masaki Nakamura, Jian Wang, Rujie Zhuang, Hiromasa Morikawa, Yuan Xue, Harald Braun, Rudi Beyaert, Nilesh Samani, Susumu Nakae, Emily Hams, Steen Dissing, Padraic G. Fallon, Robert Langer, Yihai Cao
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis thro
Externí odkaz:
https://doaj.org/article/b73ba97163914ee29b8d9b9ffa3e8e81
Autor:
Harald Braun, Guntram Suske
Publikováno v:
BioTechniques, Vol 26, Iss 6, Pp 1038-1042 (1999)
Externí odkaz:
https://doaj.org/article/dafdb171151341af83086b31666b24fe
Autor:
Fatemehsadat Esteghamat, Thamar Bryn van Dijk, Harald Braun, Sylvia Dekker, Reinier van der Linden, Jun Hou, Pavlos Fanis, Jeroen Demmers, Wilfred van IJcken, Zeliha Özgür, Rastislav Horos, Farzin Pourfarzad, Marieke von Lindern, Sjaak Philipsen
Publikováno v:
Haematologica, Vol 96, Iss 9 (2011)
Background In erythroblasts, the CoREST repressor complex is recruited to target promoters by the transcription factor Gfi1b, leading to repression of genes mainly involved in erythroid differentiation. Hmg20b is a subunit of CoREST, but its role in
Externí odkaz:
https://doaj.org/article/f2ccc08f277a4f8092f4b8f187c633fa
Autor:
Mira Haegman, Marja Kreike, Harald Braun, Rudi Beyaert, Inna S. Afonina, Marie Lork, Jens Staal, Yasmine Driege, Domien Vanneste, Styliani Iliaki
Publikováno v:
The FEBS Journal. 288:1630-1647
Signal transduction typically displays a so-called bow-tie topology: Multiple receptors lead to multiple cellular responses but the signals all pass through a narrow waist of central signaling nodes. One such signaling node for several inflammatory a
Autor:
Jens Staal, Harald Braun
Publikováno v:
The FEBS Journal. 287:3161-3164
TAB2 and TAB3 bind to K63-linked polyubiquitin chains and recruit the critical kinase MAP3K7 (TAK1). The polyubiquitin-recruited TAK1/TAB2/TAB3 complex comes in close proximity with the IKK (IKKα/IKKβ/IKKγ) complex, which is recruited to M1-linked
Publikováno v:
Telecom Extreme Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7391e8e0aa7992738f912eb3b6bd95f2
https://doi.org/10.1201/9781003160748-5
https://doi.org/10.1201/9781003160748-5