Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Harald Borbe"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1297:90-98
The strain Escherichia coli JRG26, which has a defect in the lipoic acid biosynthesis, was cultivated in the presence of R-lipoic acid, S-lipoic acid, RS-dithiolane-3-caproic acid, RS-bisnorlipoic acid, and RS-tetranorlipoic acid, respectively. With
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b363756c10f22a2ace477f72d005fd
https://doi.org/10.1016/0167-4838(96)00104-5
https://doi.org/10.1016/0167-4838(96)00104-5
Publikováno v:
Biochemical Pharmacology. 50:637-646
Lipoic acid (α-lipoic acid, thioctic acid) is applied as a therapeutic agent in various diseases accompanied by polyneuropathia such as diabetes mellitus. The stereoselectivity and specificity of lipoic acid for the pyruvate dehydrogenase complex an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bc062be1e1e4d8afdd71fd35efb03f
https://doi.org/10.1016/0006-2952(95)00175-y
https://doi.org/10.1016/0006-2952(95)00175-y
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:1091-1098
The decapeptide cetrorelix is a novel luteinizing hormone — releasing hormone (LH-RH) antagonist. For nonclinical studies concerning absorption, distribution, metabolism and excretion (ADME) in animals the [14C]-lebelled compound is essential. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75617ee4d11a86240174a25ed8f765c0
https://doi.org/10.1002/jlcr.2580341113
https://doi.org/10.1002/jlcr.2580341113
Autor:
Harald Borbe, Szelenyi I, Giancarlo Camuglia, Bernhard Kutscher, Ute Dr Achterrath-Tuckermann, Jürgen Engel, Jürgen Schmidt, Ilona Dr Fleischhauer
Publikováno v:
Chirality. 5:366-369
The racemic phthalazinone derivatives azelastine and flezelastine were resolved via formation of diastereomeric salts and fractional crystallization thereof. The optical purity of the enantiomers was checked by HPLC. Pharmacological investigations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a71643f120a78907d85b6dfbe90e094
https://doi.org/10.1002/chir.530050517
https://doi.org/10.1002/chir.530050517
Publikováno v:
European Journal of Pharmacology. 205:105-107
Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha 1-adrenoceptor antagonist. The IC50 values for alpha 1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da8ca1d50c479acd80b258d1625cd75
https://doi.org/10.1016/0014-2999(91)90779-p
https://doi.org/10.1016/0014-2999(91)90779-p
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 319:172-177
Receptor binding studies were performed with tritiated propyl β-carboline-3-carboxylate ([3H]PrCC), tritiated ethyl β-carboline-3-carboxylate ([3H]ECC), and tritiated flunitrazepam ([3H]FNT) in membrane preparations from different regions of the bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f623e0ba97e5df2db14177e0233db6f
https://doi.org/10.1007/bf00503933
https://doi.org/10.1007/bf00503933
Autor:
Hans Rommelspacher, Harald Borbe, Uwe Wollert, Walter E. Müller, Klaus J. Fehske, Christel Nanz
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 314:97-100
The interaction of several beta-carbolines with specific [3H]-flunitrazepam binding to benzodiazepine receptors in rat brain membranes was investigated. Out of the investigated compounds, harmane and norharmane were the most potent inhibitors of spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1e959a6b8ac16e8c37df6b49b9220
https://doi.org/10.1007/bf00498436
https://doi.org/10.1007/bf00498436
Autor:
Ingeborg Zube, Harald Borbe
Publikováno v:
Brain Research. 264:178-180
Using [3H]imipramine, specific imipramine binding was demonstrable in the crude membrane homogenate of bovine retina. Scatchard analysis of the saturation experiments revealed an apparent dissociation constant (Kd) of 6.4 nM and a maximal number of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a473c2ae88c28510fe0a387bd41af3bb
https://doi.org/10.1016/0006-8993(83)91140-x
https://doi.org/10.1016/0006-8993(83)91140-x
Publikováno v:
Brain research. 205(1)
Saturable, specific [3H]strychnine binding can be demonstrated in homogenates of bovine retina. Scatchard plots revealed only one set of binding sites with a dissociation constant (Kd) of about 60 nM and a maximal number of binding sites of about 1.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c700fdf01e1d9eb3c392fff759d1e3
https://pubmed.ncbi.nlm.nih.gov/6258706
https://pubmed.ncbi.nlm.nih.gov/6258706
Publikováno v:
Comparative biochemistry and physiology. C: Comparative pharmacology. 72(1)
1. Using several well-known radioligand binding techniques, α-adrenergic, muscarinic cholinergic, dopaminergic, opiate and benzodiazepine receptors could be demonstrated in human retina homogenates. 2. While all these five receptor systems are also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3262b10dd27aaff8a268f94689a1fd8
https://pubmed.ncbi.nlm.nih.gov/6125322
https://pubmed.ncbi.nlm.nih.gov/6125322