DNA Amplifications and Aneuploidy, High Proliferative Activity and Impaired Cell Cycle Control Characterize Breast Carcinomas with Poor Prognosis

Autor: Harald Blegen, John S. Will, B. Michael Ghadimi, Hesed‐Padilla Nash, Anders Zetterberg, Gert Auer, Thomas Ried

Publikováno v: Analytical Cellular Pathology, Vol 25, Iss 3, Pp 103-114 (2003)

In order to explore whether specific cytogenetic abnormalities can be used to stratify tumors with a distinctly different clinical course, we performed comparative genomic hybridization (CGH) of tumors from patients who were diagnosed with metastatic

Externí odkaz: https://doaj.org/article/921d234fd71f4a3996f9b5eb7a6e2620

Genetic Instability Promotes the Acquisition of Chromosomal Imbalances in T1b and T1c Breast Adenocarcinomas

Autor: Elina Eriksson, Harald Blegen, Anders Zetterberg, Gert Auer, Thomas Ried, B. Michael Ghadimi, Annukka Jauho

Publikováno v: Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology
Analytical Cellular Pathology, Vol 22, Iss 3, Pp 123-131 (2001)

In order to evaluate biological and genetic properties of early breast carcinomas we analyzed microdissected tissue from 33 primary breast carcinomas stage T1b and T1c with respect to the nuclear DNA content, the expression pattern of Ki‐67, cyclin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7916b802fdad1aa819c745ad3546fef9
https://doi.org/10.1155/2001/126030

Primary Carcinoma of the Fallopian Tube

Autor: Gert Auer, K. Heselmeyer, Ann Hellström, Evelin Schröck, Keerti V. Shah, Harald Blegen, Claes Silfverswärd, Thomas Ried

Publikováno v: Karolinska Institutet

Primary fallopian tube carcinoma (PFTC) is a rare and highly aggressive tumor. Twelve cases of PFTC (stages IA to IV) were analyzed by comparative genomic hybridization. The most consistent DNA gain was mapped to chromosome arm 3q in 11 of 12 cases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9f9af6917f3c8132da9d99130e5d28
https://doi.org/10.1097/00004347-199807000-00009

p53 overexpression in normal and dysplastic tissues adjacent to p53 negative squamous cell carcinomas of the head and neck

Autor: K G Wiman, Gert Auer, Tina Dalianis, Johan Lindholm, R. Kuylenstierna, Harald Blegen, Maria Malec, Ilona Lewensohn-Fuchs, Eva Munck-Wikland

Publikováno v: Karolinska Institutet

p53 overexpression was present in the normal or dysplastic epithelium, but absent in the adjacent invasive cancers of five patients with head and neck squamous cell carcinomas (HNSCC), when p53 immunostaining (IHC) was performed. In three of the five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb2b697c2afbb4a43ef20c485359633
https://doi.org/10.3892/ijo.11.1.97

Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell Surface

Autor: Anica Dricu, Peter Zickert, Magnus Hjertman, Anders Höög, Olle Larsson, Harald Blegen, Min Wang, Magdalena Carlberg

Publikováno v: Journal of Biological Chemistry. 271:17453-17462

Depletion of mevalonic acid (MVA), obtained by inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase using lovastatin, depressed the biosynthesis of dolichyl-phosphate and the rate of N-linked glycosylation and caused growth arrest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ab7db7bfde5d509165795eceab06d41
https://doi.org/10.1074/jbc.271.29.17453