Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harald Bernsteiner"'
Autor:
Theres Friesacher, Haritha P. Reddy, Harald Bernsteiner, J. Carlo Combista, Boris Shalomov, Amal K. Bera, Eva-Maria Zangerl-Plessl, Nathan Dascal, Anna Stary-Weinzinger
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Gly selectivity filter (TIGYGYR) mutant of the GIRK2 channel causes rare but severe neurological disorder called the Keppen-Lubinsky syndrome. Here, the authors explore the molecular mechanism of action of this glycine to serine mutant causing diseas
Externí odkaz:
https://doaj.org/article/06836862f38b478c94f96d2c99760011
Autor:
Theres Friesacher, Haritha P. Reddy, Harald Bernsteiner, John Carlo Combista, Boris Shalomov, Amal K. Bera, Eva-Maria Zangerl-Plessl, Nathan Dascal, Anna Stary-Weinzinger
Supplemental material to the study "A selectivity filter mutation provides insights into gating regulation of a K+ channel", published in Communications Biology. The upload contains Molecular Dynamics simulation data ofmGIRK2wt as well asmGIRK2weaver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abeca013af4c231e4541f8937a909bad
Publikováno v:
Journal of General Physiology. 151:1231-1246
Inwardly rectifying potassium (Kir) channels play a key role in controlling membrane potentials in excitable and unexcitable cells, thereby regulating a plethora of physiological processes. G-protein–gated Kir channels control heart rate and neuron
Publikováno v:
Biochemical and biophysical research communications
EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure
Autor:
Feifei Ren, Colin G. Nichols, Grigory Maksaev, Peng Yuan, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Harald Bernsteiner
Publikováno v:
The Journal of General Physiology
This paper presents the crystal structure of a forced open inward rectifier Kir2.2 channel. Molecular dynamics reveals the details of ion permeation through the open channel.
Potassium ion conduction through open potassium channels is essential
Potassium ion conduction through open potassium channels is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00994dbf7b4288f390123b4b7439f90
Publikováno v:
Biophysical Journal. 120:244a
Publikováno v:
Biophysical Journal. 118:108a
Autor:
Tobias, Linder, Harald, Bernsteiner, Priyanka, Saxena, Florian, Bauer, Thomas, Erker, Eugen, Timin, Steffen, Hering, Anna, Stary-Weinzinger
Publikováno v:
Medchemcomm
The hERG cavity can trap very bulky compounds, without perturbing normal gate closure.
Inhibition of hERG K+ channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmia
Inhibition of hERG K+ channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmia
Publikováno v:
Biophysical Journal. 112:508a