Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Harald Berchtold"'
Publikováno v:
Journal of magnetic resonance (San Diego, Calif. : 1997). 315
A new experiment for recording phase sensitive ω1-broadband homodecoupled TOCSY spectra is presented. The method is an extension of the already existing perfect echo (PE) filter, proposed to sample t1 chemical shift under sustained homodecoupling. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29762b0cddf360757b7152161380a77f
https://pubmed.ncbi.nlm.nih.gov/32464370
https://pubmed.ncbi.nlm.nih.gov/32464370
Autor:
Harald Berchtold, Anja Schüler, Robert Seckler, Gudrun Lenherr, Gerrit Hauck, Anja Thalhammer, Martin Wolff, Klaus Gast, Norbert Nagel
Publikováno v:
Pharmaceutical Research
Purpose: Comparison of the dissociation kinetics of rapid-acting insulins lispro, aspart, glulisine and human insulin under physiologically relevant conditions. Methods: Dissociation kinetics after dilution were monitored directly in terms of the ave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa6848407e5a0b3760384a242ad01f3
http://europepmc.org/articles/PMC5643355
http://europepmc.org/articles/PMC5643355
Autor:
Harald Berchtold, Melissa A. Graewert, Winfried Heyse, Cy M. Jeffries, Mimi Gao, Dmitri I. Svergun, Norbert Nagel
Publikováno v:
Biophysical chemistry. 253
The quaternary structures of insulin glargine and glulisine under formulation conditions and upon dilution using placebo or water were investigated using synchrotron small-angle X-ray scattering. Our results revealed that insulin glulisine in Apidra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ef4b0122b5eb0589c2e0060a90193c
https://pubmed.ncbi.nlm.nih.gov/31376619
https://pubmed.ncbi.nlm.nih.gov/31376619
Publikováno v:
European Journal of Pharmaceutical Sciences. 145:105215
Upon transition from research to development, a new chemical entity, which acts upon the Kv1.5-potassium channel and blocks potassium flow in the atrium of the human heart, has been subjected to a crystallization screen. The sodium salt of an anthran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54badfad9b165942371e96c0385a9097
https://doi.org/10.1016/j.ejps.2020.105215
https://doi.org/10.1016/j.ejps.2020.105215
Publikováno v:
AIChE Journal. 61:1792-1803
To investigate dynamic behaviors of monocharged particle systems, a direct truncation (DT) method and a hybrid particle-cell (HPC) method are implemented into the discrete element method coupled with computational fluid dynamics (DEM-CFD) with define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630ebf2b9a2cfffa40150db5801db657
https://doi.org/10.1002/aic.14768
https://doi.org/10.1002/aic.14768
Autor:
Harald Berchtold, Maike Windbergs, Claus-Michael Lehr, Thomas Eichinger, Stefan Balbach, Petra Loos, Ulrich F. Schaefer, Birthe Kann, Sandra P. Gantzsch, Monika Ofer-Glaessgen
Publikováno v:
Journal of Controlled Release. 175:79-86
Aim of this study was to implement a modified phospholipid vesicle-based permeation assay (PVPA) barrier as alternative to Caco-2 cell monolayers in a combined dissolution and permeation system for testing of solid dosage forms. Commercially availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e800563c32d0d75af9d38366cfdcd429
https://doi.org/10.1016/j.jconrel.2013.12.009
https://doi.org/10.1016/j.jconrel.2013.12.009
Publikováno v:
Powder Technology. 248:34-43
Contact electrification occurs in many powder handling processes and involves electrostatic charges that are transferred between contacting particles during collisions. In the current paper, a successive condenser model was developed and implemented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144cadbd3ed0908f8667b1b916ade5af
https://doi.org/10.1016/j.powtec.2013.04.014
https://doi.org/10.1016/j.powtec.2013.04.014
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 31(32)
The interaction between many proteins and hydrophobic functionalized surfaces is known to induce β-sheet and amyloid fibril formation. In particular, insulin has served as a model peptide to understand such fibrillation, but the early stages of insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca28e0eb60b2e238890f8956a22538f0
https://pubmed.ncbi.nlm.nih.gov/26212147
https://pubmed.ncbi.nlm.nih.gov/26212147
© 2014 Elsevier Ltd. The electrostatic charge can be transferred between particles during collisions. The particle shape plays an important role and, in the current study, the charge accumulation and distribution on elongated particles in a vibratin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8b60db32941af47dba2dbdcd0b92af
https://surrey.eprints-hosting.org/808587/
https://surrey.eprints-hosting.org/808587/
Publikováno v:
Drugs
The epoch-making discovery of insulin heralded a new dawn in the management of diabetes. However, the earliest, unmodified soluble insulin preparations were limited by their short duration of action, necessitating multiple daily injections. Initial a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8298fb74bfc0bdeced56d18829b3663
https://pubmed.ncbi.nlm.nih.gov/24866023
https://pubmed.ncbi.nlm.nih.gov/24866023