Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Harald App"'
Publikováno v:
Organic Letters. 1:431-434
Bis(indolyl)dihydroxyquinone 2, the tetrahydro analogue of naturally occurring 1a, was synthesized by a novel, expeditious route. The short synthesis was accomplished by treating p-bromanil (3) with 2 equiv of indole 4 in the presence of cesium carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d897bf7c86bc4e5f19d5c0f228193dc0
https://doi.org/10.1021/ol990075b
https://doi.org/10.1021/ol990075b
Autor:
Harald App, Michele Luche, Gerald Mcmahon, Audie Rice, Ben Margolis, Henry Pu, Khisal A. Alvi, Heidi Dare
Publikováno v:
The Journal of Antibiotics. 52:215-223
Five new asterriquinone analogs (2-4, 6, 7), together with previously identified neoasterriquinone (1) and isoasterriquinone (5), were isolated from a fermentation broth of the fungus Aspergillus candidus and purified by HSCCC (high speed counter cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a85729d17b19173e64d7e071b8d4e4
https://doi.org/10.7164/antibiotics.52.215
https://doi.org/10.7164/antibiotics.52.215
Autor:
Gerald M. McMahon, Frank D. Bohmer, Harald App, Aviv Gazit, Jefferey Chen, Alexander Levitzki
Publikováno v:
Journal of Medicinal Chemistry. 39:2170-2177
A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The potency of the inhibitors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d30728766c1982ee166b1c385143c5d
https://doi.org/10.1021/jm950727b
https://doi.org/10.1021/jm950727b
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d094f9ea2c9993cbcaf626cf9b77555
https://doi.org/10.1002/chin.199637219
https://doi.org/10.1002/chin.199637219
Autor:
Audie Rice, Michele Luche, Ben Margolis, Gerald Mcmahon, Khisal A. Alvi, Henry Pu, Harald App, Heidi Dare
Publikováno v:
ChemInform. 30
Five new asterriquinone analogs (2-4, 6, 7), together with previously identified neoasterriquinone (1) and isoasterriquinone (5), were isolated from a fermentation broth of the fungus Aspergillus candidus and purified by HSCCC (high speed counter cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94985780520b277d171e18777652fcab
https://doi.org/10.1002/chin.199933272
https://doi.org/10.1002/chin.199933272
Autor:
Joseph Avruch, Ulf R. Rapp, Harald App, John M. Kyriakis, David L. Brautigan, Xian-feng Zhang, Papia Banerjee
Publikováno v:
Nature. 358:417-421
THE normal cellular homologue of the acutely transforming oncogene v-ra/is c-raf-l, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli1. The physiological substrates of the protein c-Raf-1 are unknown. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d8f1a54acfde8fa2a6139d47dd1a28
https://doi.org/10.1038/358417a0
https://doi.org/10.1038/358417a0
Publikováno v:
Proceedings of the National Academy of Sciences. 88:1227-1231
Interleukin 2 (IL-2) is a lymphokine, produced by T cells upon antigenic or mitogenic stimulation, that is a critical regulator of T-cell proliferation. Although the binding of IL-2 to its receptor has been well characterized, the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8779ba792ccfa9a18c6d865396d04e
https://doi.org/10.1073/pnas.88.4.1227
https://doi.org/10.1073/pnas.88.4.1227
Publikováno v:
Journal of medicinal chemistry. 41(14)
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ac236c2e4a8b0319729cb8b10e24d4
https://pubmed.ncbi.nlm.nih.gov/9651163
https://pubmed.ncbi.nlm.nih.gov/9651163
Autor:
Jeffrey Chen, Aviv Gazit, Gerald McMahon, Alexander Levitzki, Harald App, Peter Hirth, Irit Chen
Publikováno v:
Bioorganicmedicinal chemistry. 4(8)
Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4117ddaa87cf7a2b1d74709a90ebb6fb
https://pubmed.ncbi.nlm.nih.gov/8879541
https://pubmed.ncbi.nlm.nih.gov/8879541
Autor:
Randall Schreck, Terence Hui, Axel Ullrich, Laura K. Shawver, Mohammad Azam, T. J. Powell, Miloe McCall, Audie Rice, Harald App
Publikováno v:
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 17(4)
A recently described tumor-derived glycoprotein, designated 90K, has been shown to have positive effects on the generation of cytotoxic effector cells (NK/LAK) from human PBMC. To determine the mechanism of these effects, we have examined the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501009eb4f6026de7cbd5dcf761e0f1f
https://pubmed.ncbi.nlm.nih.gov/7582257
https://pubmed.ncbi.nlm.nih.gov/7582257