Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Harald, Steiner"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid precursor protein (APP) involved in Alzheimer’s disease pathology and other transmembrane proteins. Substrate-bound structures reveal a stable hybrid β-sheet imme
Externí odkaz:
https://doaj.org/article/48b0616409a4499db90dfcc202d4e365
Autor:
Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Deuterium/hydrogen exchange shows that conformational flexibility of the hybrid transmembrane domains (TMD) of amyloid precursor proteins plays a role in TMD cleavability by γ-secretase in vitro and in cellulo.
Externí odkaz:
https://doaj.org/article/f8c5876c1e1f44b2bcdc3ca0c114697b
Autor:
Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-17 (2022)
Abstract Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly unders
Externí odkaz:
https://doaj.org/article/9be7449636e44c638a2a638ecfb8a4fe
Autor:
Lukas P Feilen, Shu-Yu Chen, Akio Fukumori, Regina Feederle, Martin Zacharias, Harald Steiner
Publikováno v:
eLife, Vol 11 (2022)
Cleavage of membrane proteins in the lipid bilayer by intramembrane proteases is crucial for health and disease. Although different lipid environments can potently modulate their activity, how this is linked to their structural dynamics is unclear. H
Externí odkaz:
https://doaj.org/article/7c5c5d512e374ee1acce648e2de1a369
Autor:
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Publikováno v:
eLife, Vol 10 (2021)
Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown. Here, we identify microbiota-derived short
Externí odkaz:
https://doaj.org/article/f7e1c8681be24568b1770df48198e501
Publikováno v:
Cell Stress, Vol 2, Iss 11, Pp 292-310 (2018)
Alzheimer´s disease (AD) is a devastating neurodegenerative disease of the elderly population. Genetic evidence strongly suggests that aberrant generation and/or clearance of the neurotoxic amyloid-β peptide (Aβ) is triggering the disease. Aβ is
Externí odkaz:
https://doaj.org/article/bd8bb33a54fc4af8b1529494f54a32b6
Autor:
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1356-1365 (2017)
Abstract Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer's disease (AD) and other neurodeg
Externí odkaz:
https://doaj.org/article/6286c9de51494f55b8a3a286de404302
Autor:
Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner, Evamarie Hey-Hawkins
Publikováno v:
Molecules, Vol 26, Iss 10, p 2843 (2021)
All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyl
Externí odkaz:
https://doaj.org/article/9537748cb2df47b69a4f40088f5e7794
Autor:
Benedikt Kretner, Johannes Trambauer, Akio Fukumori, Janina Mielke, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan F Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 458-465 (2016)
Abstract As stated by the prevailing amyloid cascade hypothesis, Alzheimer's disease (AD) is caused by the aggregation and cerebral deposition of long amyloid‐β peptide (Aβ) species, which are released from a C‐terminal amyloid precursor protei
Externí odkaz:
https://doaj.org/article/57489df83deb47b496e7a64e1e5c8050
Autor:
Harald Steiner
Publikováno v:
Die Personalvertretung.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d402a726c3b3b8e720501a6d7ce6a4a
https://doi.org/10.37307/j.1868-7857.2023.01.04
https://doi.org/10.37307/j.1868-7857.2023.01.04