Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Harald, Staiger"'
Autor:
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show tha
Externí odkaz:
https://doaj.org/article/718976e80f5648f99659b5ea904f47e5
Autor:
Laura Stirm, Peter Huypens, Steffen Sass, Richa Batra, Louise Fritsche, Sara Brucker, Harald Abele, Anita M. Hennige, Fabian Theis, Johannes Beckers, Martin Hrabě de Angelis, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0a645f5ef2d14b18a78a391a9f8dbc6b
Autor:
Felicia Gerst, Robert Wagner, Morgana Barroso Oquendo, Dorothea Siegel-Axel, Andreas Fritsche, Martin Heni, Harald Staiger, Hans-Ulrich Häring, Susanne Ullrich
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 1-10 (2019)
Background: It is now generally accepted that obesity is a major risk factor for type 2 diabetes mellitus (T2DM). Hepatic steatosis in particular, as well as visceral and ectopic fat accumulation within tissues, is associated with the development of
Externí odkaz:
https://doaj.org/article/6a160ecb7bd24de290ba6b22c621be76
Autor:
Xianming Wang, Michael Sterr, Ansarullah, Ingo Burtscher, Anika Böttcher, Julia Beckenbauer, Johanna Siehler, Thomas Meitinger, Hans-Ulrich Häring, Harald Staiger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 80-97 (2019)
Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large cohort of subjects with increased risk for diabetes and
Externí odkaz:
https://doaj.org/article/38c7550f0463430bba653e3eba240c45
Autor:
Michaela Keuper, Lucia Berti, Bernhard Raedle, Stephan Sachs, Anja Böhm, Louise Fritsche, Andreas Fritsche, Hans-Ulrich Häring, Martin Hrabě de Angelis, Martin Jastroch, Susanna M. Hofmann, Harald Staiger
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 28-37 (2019)
Background/Objectives: Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial
Externí odkaz:
https://doaj.org/article/673dd5d3e16b41cdb1c7cbe7b5227953
Autor:
Martin Heni, Sabine S. Eckstein, Jens Schittenhelm, Anja Böhm, Norbert Hogrefe, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Harald Staiger
Publikováno v:
Royal Society Open Science, Vol 7, Iss 9 (2020)
Astrocytes provide neurons with structural support and energy in form of lactate, modulate synaptic transmission, are insulin sensitive and act as gatekeeper for water, ions, glutamate and second messengers. Furthermore, astrocytes are important for
Externí odkaz:
https://doaj.org/article/998f7a345f3d43b09fb65dec017af0d7
Autor:
Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 191-202 (2018)
Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to mod
Externí odkaz:
https://doaj.org/article/b1ef48bbeaea42e1bde4adba3cb019bf
Autor:
Pascal Gottmann, Meriem Ouni, Sophie Saussenthaler, Julian Roos, Laura Stirm, Markus Jähnert, Anne Kamitz, Nicole Hallahan, Wenke Jonas, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger, Matthias Blüher, Pamela Fischer-Posovszky, Heike Vogel, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 145-159 (2018)
Objective: Obesity and type 2 diabetes (T2D) arise from the interplay between genetic, epigenetic, and environmental factors. The aim of this study was to combine bioinformatics and functional studies to identify miRNAs that contribute to obesity and
Externí odkaz:
https://doaj.org/article/b43f895593b3447b9e47be298c257584
Autor:
Xianming Wang, Michael Sterr, Ingo Burtscher, Shen Chen, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Michael Ray, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 57-68 (2018)
Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the fu
Externí odkaz:
https://doaj.org/article/1191a257d4294ce78a3966838b2d29b0
Autor:
Stefan Zoltán Lutz, Jörg Hennenlotter, Marcus Oliver Scharpf, Corinna Sailer, Louise Fritsche, Vera Schmid, Konstantinos Kantartzis, Robert Wagner, Rainer Lehmann, Lucia Berti, Andreas Peter, Harald Staiger, Andreas Fritsche, Falko Fend, Tilman Todenhöfer, Arnulf Stenzl, Hans-Ulrich Häring, Martin Heni
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 158-166 (2018)
Objective: While prostate cancer does not occur more often in men with diabetes, survival is markedly reduced in this patient group. Androgen signaling is a known and major driver for prostate cancer progression. Therefore, we analyzed major componen
Externí odkaz:
https://doaj.org/article/4a1bfcb50401442287247dc28d054760