Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Harald, Hübner"'
Autor:
Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro, Liel Sapir, Tara Pfeiffer, Lukas Waterloo, Harald Hübner, Yoav Peleg, Peter Gmeiner, Peter J. McCormick, Dorothee Weikert, Masha Y. Niv, Moran Shalev-Benami
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of tastants. Among 25 functional TAS2Rs encoded in the human genome, TAS2R14 is
Externí odkaz:
https://doaj.org/article/ffe236aefc0341b29447e20725da57e1
Autor:
Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Background The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work reports the development of
Externí odkaz:
https://doaj.org/article/7220bee43e0941a9b4e53a8f1aa38dba
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine a
Externí odkaz:
https://doaj.org/article/06de6af761474c2b9a90d90838043ba7
Autor:
Jun Xu, Qinggong Wang, Harald Hübner, Yunfei Hu, Xiaogang Niu, Haoqing Wang, Shoji Maeda, Asuka Inoue, Yuyong Tao, Peter Gmeiner, Yang Du, Changwen Jin, Brian K. Kobilka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
Externí odkaz:
https://doaj.org/article/2a8a4fc6bad2451e913c4050e4dba574
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a33640b5b5bf4ee68a4f3543dfc0d68f
Autor:
Deborah Wenk, Vladimir Ignatchenko, Andrew Macklin, Harald Hübner, Peter Gmeiner, Dorothée Weikert, Monika Pischetsrieder, Thomas Kislinger
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The development of functionally selective or biased ligands is a promising approach towards drugs with less side effects. Biased ligands for G protein-coupled receptors can selectively induce G protein activation or β-arrestin recruitment.
Externí odkaz:
https://doaj.org/article/e7271728fe8049c8a10edf9dadf9f5a6
Autor:
Anni Allikalt, Nirupam Purkayastha, Khajidmaa Flad, Maximilian F. Schmidt, Alina Tabor, Peter Gmeiner, Harald Hübner, Dorothee Weikert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Fluorescent ligands are versatile tools for the study of G protein-coupled receptors. Depending on the fluorophore, they can be used for a range of different applications, including fluorescence microscopy and bioluminescence or fluorescence
Externí odkaz:
https://doaj.org/article/917ec5091e204abdb7245329c218d9c8
Autor:
Lukas Waterloo, Harald Hübner, Fabrizio Fierro, Tara Pfeiffer, Regine Brox, Stefan Löber, Dorothee Weikert, Masha Y. Niv, Peter Gmeiner
Publikováno v:
Journal of Medicinal Chemistry. 66:3499-3521
The bitter taste receptor TAS2R14 is a G protein-coupled receptor that is found on the tongue as well as in the human airway smooth muscle and other extraoral tissues. Because its activation causes bronchodilatation, TAS2R14 is a potential target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3b7598c93aa9e4d67a6bea1aac27e2
https://doi.org/10.1021/acs.jmedchem.2c01997
https://doi.org/10.1021/acs.jmedchem.2c01997
Autor:
Deborah Wenk, Shahbaz Khan, Vladimir Ignatchenko, Harald Hübner, Peter Gmeiner, Dorothee Weikert, Monika Pischetsrieder, Thomas Kislinger
Publikováno v:
Journal of Proteome Research. 22:259-271
Leveraging biased signaling of G protein-coupled receptors has been proposed as a promising strategy for the development of drugs with higher specificity. However, the consequences of selectively targeting G protein- or β-arrestin-mediated signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bab716f78d4948b40e20f1e8aa2e82
https://doi.org/10.1021/acs.jproteome.2c00707
https://doi.org/10.1021/acs.jproteome.2c00707
Autor:
Johannes Köckenberger, Oliver Fischer, Andreas Konopa, Sebastian Bergwinkl, Susanne Mühlich, Peter Gmeiner, Roger Jan Kutta, Harald Hübner, Max Keller, Markus R. Heinrich
Publikováno v:
Journal of Medicinal Chemistry. 65:16494-16509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a70bf2dc98527b9eab65fd6b6b5df2e
https://doi.org/10.1021/acs.jmedchem.2c01376
https://doi.org/10.1021/acs.jmedchem.2c01376