Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Harald, Gröger"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Recently, the program INTMSAlign_HiSol for identifying aggregation hotspots in proteins only requiring secondary structure data was introduced. We explored the utility of this program further and applied it for engineering of the aldoxime de
Externí odkaz:
https://doaj.org/article/07ea2c0a72214d78b00d5898091ddd88
Publikováno v:
ChemistryOpen, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract The access towards chiral nitriles remains crucial in the synthesis of several pharmaceuticals. One approach is based on metal‐catalyzed dehydration of chiral aldoximes, which are generated from chiral pool‐derived aldehydes as substrate
Externí odkaz:
https://doaj.org/article/9d2dd2c3c5464e5cbb4a3b898c79441c
Publikováno v:
Advanced Science, Vol 7, Iss 13, Pp n/a-n/a (2020)
Abstract A biotechnological approach toward the plant metabolite and regulator cis‐(+)‐12‐oxophytodienoic acid (cis‐(+)‐12‐OPDA) in a one‐pot process with >99% conversion, at least 90% selectivity and ≤10% of side products as well as
Externí odkaz:
https://doaj.org/article/f10ec8d08dc84d39afe65fd48d144360
Autor:
Madita Knieper, Lara Vogelsang, Tim Guntelmann, Jens Sproß, Harald Gröger, Andrea Viehhauser, Karl-Josef Dietz
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 855 (2022)
cis-(+)-12-Oxophytodienoic acid (OPDA) is a reactive oxylipin produced by catalytic oxygenation of polyunsaturated α-linolenic acid (18:3 (ω − 3)) in the chloroplast. Apart from its function as precursor for jasmonic acid synthesis, OPDA serves a
Externí odkaz:
https://doaj.org/article/a421ba6f6f5544dbb98222e82be3ce0e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Typically, preparation of the polymer precursors α,ω-dinitriles requires hydrogen cyanide. Here, the authors use aldoxime hydratase to produce adiponitrile and related aliphatic linear dinitriles under ambient conditions starting from readily avail
Externí odkaz:
https://doaj.org/article/542a27835d1f47949ad6968f969e4f12
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The 3-thiazolidine ring, a pharmaceutically interesting cyclic structural element found e.g. in some antibiotics, is hard to obtain via currently used approaches. Here, the authors developed a straightforward method to efficiently synthesize a variet
Externí odkaz:
https://doaj.org/article/70159b5ac5fd47009fa14f6aef22e6b2
Publikováno v:
The Journal of Organic Chemistry. 87:11369-11378
In this work, an enantioselective biocatalytic synthesis of chiral thiomorpholines using imine reductases (IREDs) is described. As substrates, four prochiral and one chiral 3,6-dihydro-2H-1,4-thiazines were synthesized in a modified Asinger reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbbe7001f0a6647aa45e736b1392ad7
https://doi.org/10.1021/acs.joc.2c00839
https://doi.org/10.1021/acs.joc.2c00839
Autor:
Bastian Altemeier, Harald Gröger
Publikováno v:
European Journal of Organic Chemistry.
In this contribution, we describe a new approach to apply thermodynamically unfavored reactions in synthetic chemistry and to integrate them in cascade processes. By means of a new developed procedure for multi-step one-pot syntheses, we succeeded in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e066efb2e2bc24f538024a8da9448a5
https://doi.org/10.1002/ejoc.202300018
https://doi.org/10.1002/ejoc.202300018
Autor:
Kengo Kasama, Yuya Hinami, Karin Mizuno, Satoshi Horino, Tomoya Nishio, Chiharu Yuki, Kyohei Kanomata, Gamal A. I. Moustafa, Harald Gröger, Shuji Akai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:391-399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::195c484a7ab82cfa570f8db201daaed7
https://doi.org/10.1248/cpb.c22-00021
https://doi.org/10.1248/cpb.c22-00021
Publikováno v:
Organic Process Research & Development. 26:2067-2074
Process development and optimization for an enzymatic reduction of 2-aryl-substituted pyrrolines to enantioselectively access the corresponding pyrrolidines have been carried out. Such chiral pyrrolidines are of high pharmaceutical interest and repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6edd562dbb19c9788b1a2c5f657ab25
https://doi.org/10.1021/acs.oprd.1c00471
https://doi.org/10.1021/acs.oprd.1c00471