Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Harald, Genth"'
Autor:
Lara Petersen, Svenja Stroh, Dennis Schöttelndreier, Guntram A. Grassl, Klemens Rottner, Cord Brakebusch, Jörg Fahrer, Harald Genth
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Clostridioides difficile infection (CDI) in humans causes pseudomembranous colitis (PMC), which is a severe pathology characterized by a loss of epithelial barrier function and massive colonic inflammation. PMC has been attributed to the action of tw
Externí odkaz:
https://doaj.org/article/b1f04be715304d8a9356e07ba4160c2a
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Toxin producing Clostridioides difficile strains cause gastrointestinal infections with the large glucosylating protein toxins A (TcdA) and B (TcdB) being major virulence factors responsible for the onset of symptoms. TcdA and TcdB enter their target
Externí odkaz:
https://doaj.org/article/f1fe8200760f4f4a880996b6ecabcdd2
Publikováno v:
Cells, Vol 10, Iss 11, p 2931 (2021)
The dermis is the connective layer between the epidermis and subcutis and harbours nerve endings, glands, blood vessels, and hair follicles. The most abundant cell type is the fibroblast. Dermal fibroblasts have a versatile portfolio of functions wit
Externí odkaz:
https://doaj.org/article/5d6471c65a1549b489b49d61d3cf793b
Autor:
Harald Genth, Johannes Junemann, Chantal M. Lämmerhirt, Arlen-Celina Lücke, Ilona Schelle, Ingo Just, Ralf Gerhard, Andreas Pich
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Clostridioides difficile toxin A (TcdA) and Toxin B (TcdB) trigger inflammasome activation with caspase-1 activation in cultured cells, which in turn induce the release of IL-6, IFN-γ, and IL-8. Release of these proinflammatory responses is positive
Externí odkaz:
https://doaj.org/article/20d79bb1da1a412bb021f855f28b773e
Autor:
Dennis Schöttelndreier, Katrin Seeger, Guntram A. Grassl, Markus R. Winny, Robert Lindner, Harald Genth
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Toxin-producing strains of Clostridioides difficile and Clostridium perfringens cause infections of the gastrointestinal tract in humans and ruminants, with the toxins being major virulence factors, essential for the infection, and responsible for th
Externí odkaz:
https://doaj.org/article/fbfe147209154792b919afc9352339ee
Publikováno v:
Toxins, Vol 7, Iss 2, Pp 621-637 (2015)
The Gram-negative, intracellular bacterium Chlamydia trachomatis causes acute and chronic urogenital tract infection, potentially leading to infertility and ectopic pregnancy. The only partially characterized cytotoxin CT166 of serovar D exhibits a D
Externí odkaz:
https://doaj.org/article/17befd583b7f4dc7a84a69511255778a
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9939
C. novyi type A produces the alpha-toxin (TcnA) that belongs to the large clostridial glucosylating toxins (LCGTs) and is able to modify small GTPases by N-acetylglucosamination on conserved threonine residues. In contrast, other LCGTs including Clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f573ceba9512326903fe135bc3f243
Autor:
Cuihong Fan, Zhaojia Wu, David M. L. Cooper, Adam Magnus, Kim Harrison, B. Frank Eames, Rajni Chibbar, Gary Groot, Junqiong Huang, Harald Genth, Jun Zhang, Xing Tan, Yulin Deng, Jim Xiang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5593
Simulated microgravity (SMG) inhibits osteoblast differentiation (OBD) and induces bone loss via the inhibition of the Wnt/β-catenin pathway. However, the mechanism by which SMG alters the Wnt/β-catenin pathway is unknown. We previously demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fc0c1a7accc97d9fc84af054a4e7a9
Publikováno v:
Toxins, Vol 5, Iss 1, Pp 106-119 (2013)
Clostridium difficile toxin A (TcdA) and toxin B (TcdB) are the causative agent of the C. difficile-associated diarrhea (CDAD) and its severe form, the pseudomembranous colitis (PMC). TcdB from the C. difficile strain VPI10463 mono-glucosylates (ther
Externí odkaz:
https://doaj.org/article/4885958cce1840eba46cf40040dcf782
Autor:
Lara, Petersen, Svenja, Stroh, Dennis, Schöttelndreier, Guntram A, Grassl, Klemens, Rottner, Cord, Brakebusch, Jörg, Fahrer, Harald, Genth
Publikováno v:
Frontiers in microbiology. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e744ea4d01fc56b91726947cf2126256
https://pubmed.ncbi.nlm.nih.gov/35321078
https://pubmed.ncbi.nlm.nih.gov/35321078