Výsledky vyhledávání - "Haquima ElMourabit"

Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity

Autor: Alain J.P. Alix, Erika Bourguet, William Hornebeck, Georges Bellon, Janos Sapi, Martine Decarme, Franck Augé, Dominique Guillaume, Matthieu Rouffet, Jean-Yves Laronze, Gautier Moroy, Gwennaël LeDour, Haquima ElMourabit

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2008, 16 (18), pp.8745-8759

Hydrazide derivatives of Ilomastat, carrying either aryl groups or distinct alkyl and arylsulfonyl moieties were synthesized and evaluated for their MMP inhibitory activity. Potent and selective MMP-9 inhibition (IC(50)=3 nM) was observed for compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af2ae322afd654eddc62eec96fd86f1
https://doi.org/10.1016/j.bmc.2008.07.041

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