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Akademický článek

Treatment of three pediatric AML co-expressing NUP98-NSD1, FLT3-ITD, and WT1

Autor: Li Liu, Qi Nie, Zugang Xiao, Xin Chen, Chunhui Yang, Xiaoyan Mao, Na Li, Yan Zhou, Qulian Guo, Xin Tian

Publikováno v: BMC Pediatrics, Vol 24, Iss 1, Pp 1-6 (2024)

Abstract During the treatment of 89 pediatric patients with Acute Myeloid Leukemia (AML) at the Hematology Department of Kunming Medical University’s Children’s Hospital from 2020 to 2023, three patients were identified to co-express the NUP98-NS

Externí odkaz: https://doaj.org/article/998f1c92bb2543e9844b739c4036f46b

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Akademický článek

Comparison of upfront haploidentical hematopoietic stem cell transplantation and salvage haploidentical hematopoietic stem cell transplantation after immunosuppressive therapy in children with acquired severe aplastic anemia - a multicenter study

Autor: Danqi Luo, Yuhua Qu, Dao Wang, Benshan Zhang, Ming Sun, Hao Xiong, Jun Lu, Rui Yang, Mingyi Zhao, Haiyan Liu, Hua Jiang

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundFor children with severe aplastic anemia, if the first immunosuppressive therapy (IST) fails, it is not recommended to choose a second IST. Therefore, for patients without matched sibling donor (MSD) and matched unrelated donor (MUD), haplo

Externí odkaz: https://doaj.org/article/c65f4838db1c4f36a6ffa03708e12790

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Akademický článek

Haploidentical HSCT in the Treatment of Pediatric Hematological Disorders

Autor: Anna Marszołek, Maria Leśniak, Anna Sekunda, Aleksander Siwek, Zuzanna Skiba, Monika Lejman, Joanna Zawitkowska

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6380 (2024)

Allogeneic hematopoietic stem cell transplantation has become a treatment option for otherwise non-curative conditions, both malignant and benign, affecting children and adults. Nevertheless, the latest research has been focusing extensively on trans

Externí odkaz: https://doaj.org/article/f1dec0b77ffb419a95ec49d1424fddad

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Akademický článek

Galectin‐9 alleviates acute graft‐versus‐host disease after haplo‐hematopoietic stem cell transplantation by regulating regulatory T cell/effector T cell imbalance

Autor: Nannan Pang, Shabaaiti Tudahong, Yuejie Zhu, Jiang He, Chunxia Han, Gang Chen, Weiguo Wang, Jing Wang, Jianbing Ding

Publikováno v: Immunity, Inflammation and Disease, Vol 12, Iss 2, Pp n/a-n/a (2024)

Abstract Background Acute graft‐versus‐host disease (aGVHD) arises from the imbalance of host T cells. Galectin‐9 negatively regulates CD4 effector T cell (Th1 and Th17) function by binding to Tim‐3. However, the relationship between Galectin

Externí odkaz: https://doaj.org/article/ff903e206271413e9f762fd2ea6da749

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Akademický článek

Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundDonor-specific antibodies (DSAs) are IgG allo-antibodies against mismatched donor HLA molecules and can cause graft failure (GF) in the setting of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Our aim was to report th

Externí odkaz: https://doaj.org/article/d812f3ccea2048e3ae13b72a5bfca97c

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Akademický článek

Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies

Autor: Lan Wang, Kai Ji, Luyao Chen, Ying Li, Wenjuan Zhu, Xiaoni Yuan, Xiaojing Bao, Xiaojin Wu, Jun He

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

To examine the production time, type, and MFI of post-transplantation de novo HLA antibodies, and their effects on haplo-HSCT outcomes, we retrospectively included 116 patients who were negative for pre-existing HLA antibodies. In total, 322 serum sa

Externí odkaz: https://doaj.org/article/e3d86be3b5ed4780a132c7cb7a6ca0f9

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Akademický článek

Donor selection for KIR alloreactivity is associated with superior survival in haploidentical transplant with PTCy

Autor: Jun Zou, Piyanuch Kongtim, Samer A. Srour, Uri Greenbaum, Johannes Schetelig, Falk Heidenreich, Henning Baldauf, Brandt Moore, Supawee Saengboon, Yudith Carmazzi, Gabriela Rondon, Qing Ma, Katayoun Rezvani, Elizabeth J. Shpall, Richard E. Champlin, Stefan O. Ciurea, Kai Cao

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

With the continuous increase in the use of haploidentical donors for transplantation, the selection of donors becomes increasingly important. Haploidentical donors have been selected primarily based on clinical characteristics, while the effects of k

Externí odkaz: https://doaj.org/article/9d37af7a0cea49a7be02530929ccd9ba

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Akademický článek

Clinical Significance of Haplo-Fever and Cytokine Profiling After Graft Infusion in Allogeneic Stem Cell Transplantation From Haplo-Identical Donors

Autor: Lining Wang, Bo Dai, Wenhui Gao, Jing Wang, Ming Wan, Runshu Wang, Ling Wang, Jieling Jiang, Didier Blaise, Jiong Hu

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Allogeneic stem cell transplantation from haplo-identical donors (haplo-HSCT) has become a well-established therapeutic option for hematological malignancies. The fever of unknown origin (haplo-fever) early after the infusion of T cell repleted graft

Externí odkaz: https://doaj.org/article/732fa7ed655f4dda9f82e66bd29aec60

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