Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Haozhong Ding"'
Autor:
Javad Garousi, Haozhong Ding, Emma von Witting, Tianqi Xu, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Sophia Hober, Torbjörn Gräslund, Vladimir Tolmachev
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1847 (2021)
Albumin binding domain derived affinity proteins (ADAPTs) are a class of small and folded engineered scaffold proteins that holds great promise for targeting cancer tumors. Here, we have extended the in vivo half-life of an ADAPT, targeting the human
Externí odkaz:
https://doaj.org/article/63cc572ea3ff4bcab28ecc7f10b18676
Autor:
Haozhong Ding, Tianqi Xu, Jie Zhang, Vladimir Tolmachev, Maryam Oroujeni, Anna Orlova, Torbjörn Gräslund, Anzhelika Vorobyeva
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 430 (2021)
Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules’ loading and spatial arrangement. Here, the impact of increasi
Externí odkaz:
https://doaj.org/article/0871bfea14684f49be69a95f9f58de75
Autor:
Haozhong Ding, Mohamed Altai, Wen Yin, Sarah Lindbo, Hao Liu, Javad Garousi, Tianqi Xu, Anna Orlova, Vladimir Tolmachev, Sophia Hober, Torbjörn Gräslund
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 391 (2020)
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer therapy, and targeted therapies are often used in regimens for patients with a high HER2 expression level. Despite the success of current drugs, a number
Externí odkaz:
https://doaj.org/article/9c893e988a8a499485561209b4a0df19
Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs
Autor:
Wen Yin, Tianqi Xu, Haozhong Ding, Jie Zhang, Vitalina Bodenko, Maria S. Tretyakova, Mikhail V. Belousov, Yongsheng Liu, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva
Publikováno v:
Journal of Controlled Release. 355:515-527
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639e7a6dd1af9f77daaba69e0a77e44e
https://doi.org/10.1016/j.jconrel.2023.02.005
https://doi.org/10.1016/j.jconrel.2023.02.005
Autor:
Vorobyeva, Sergey M. Deyev, Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Javad Garousi, Sara S. Rinne, Maria Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika
Publikováno v:
Cancers; Volume 13; Issue 14; Pages: 3589
The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::7690de091924798f4ddd7088bc1205a9
Autor:
Tianqi Xu, Haozhong Ding, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund
Publikováno v:
Cancers
Volume 13
Issue 1
Cancers, Vol 13, Iss 85, p 85 (2021)
Volume 13
Issue 1
Cancers, Vol 13, Iss 85, p 85 (2021)
Simple Summary Drug conjugates, consisting of a tumor targeting part coupled to a highly toxic molecule, are promising for treatment of many different types of cancer. However, for many patients it is not curative, and investigation of alternative or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e869968cba715d5f66eac651bf3e347
Autor:
Vladimir Tolmachev, Hao Liu, Mohamed Altai, Per-Henrik Edqvist, Anna Orlova, Bogdan Mitran, Torbjörn Gräslund, Haozhong Ding
Publikováno v:
Journal of Controlled Release. 288:84-95
Patients with HER2-positive tumors often suffer resistance to therapy, warranting development of novel treatment modalities. Affibody molecules are small affinity proteins which can be engineered to bind to desired targets. They have in recent years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4a3aad0bf815d1651c9c334358f2c2
https://doi.org/10.1016/j.jconrel.2018.08.040
https://doi.org/10.1016/j.jconrel.2018.08.040
Autor:
Sergey M, Deyev, Anzhelika, Vorobyeva, Alexey, Schulga, Ayman, Abouzayed, Tyran, Günther, Javad, Garousi, Elena, Konovalova, Haozhong, Ding, Torbjörn, Gräslund, Anna, Orlova, Vladimir, Tolmachev
Publikováno v:
International journal of biological macromolecules. 145
Radionuclide-based imaging of molecular therapeutic targets might facilitate stratifying patients for specific biotherapeutics. New type of imaging probes, based on designed ankyrin repeat proteins (DARPins), have demonstrated excellent contrast of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::393f46b0682032b2e9eff91e22b44c62
https://pubmed.ncbi.nlm.nih.gov/31863835
https://pubmed.ncbi.nlm.nih.gov/31863835