Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Haozhong Ding"'
Autor:
Javad Garousi, Haozhong Ding, Emma von Witting, Tianqi Xu, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Sophia Hober, Torbjörn Gräslund, Vladimir Tolmachev
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1847 (2021)
Albumin binding domain derived affinity proteins (ADAPTs) are a class of small and folded engineered scaffold proteins that holds great promise for targeting cancer tumors. Here, we have extended the in vivo half-life of an ADAPT, targeting the human
Externí odkaz:
https://doaj.org/article/63cc572ea3ff4bcab28ecc7f10b18676
Autor:
Tianqi Xu, Anzhelika Vorobyeva, Alexey Schulga, Elena Konovalova, Olga Vorontsova, Haozhong Ding, Torbjörn Gräslund, Liubov A. Tashireva, Anna Orlova, Vladimir Tolmachev, Sergey M. Deyev
Publikováno v:
Cancers, Vol 13, Iss 16, p 3939 (2021)
Efficient treatment of disseminated ovarian cancer (OC) is challenging due to its heterogeneity and chemoresistance. Overexpression of human epidermal growth factor receptor 2 (HER2) and epithelial cell adhesion molecule (EpCAM) in approx. 30% and 70
Externí odkaz:
https://doaj.org/article/15b5b7795c4f42b98664a33255ce8aee
Autor:
Sergey M. Deyev, Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Javad Garousi, Sara S. Rinne, Maria Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Publikováno v:
Cancers, Vol 13, Iss 14, p 3589 (2021)
The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affini
Externí odkaz:
https://doaj.org/article/30a2d0c61c974613acc33ff194aec89c
Autor:
Haozhong Ding, Tianqi Xu, Jie Zhang, Vladimir Tolmachev, Maryam Oroujeni, Anna Orlova, Torbjörn Gräslund, Anzhelika Vorobyeva
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 430 (2021)
Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules’ loading and spatial arrangement. Here, the impact of increasi
Externí odkaz:
https://doaj.org/article/0871bfea14684f49be69a95f9f58de75
Autor:
Tianqi Xu, Haozhong Ding, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund
Publikováno v:
Cancers, Vol 13, Iss 1, p 85 (2020)
The human epidermal growth factor receptor 2 (HER2) is frequently overexpressed in a variety of cancers and therapies targeting HER2 are routinely used in the clinic. Recently, small engineered scaffold proteins, such as affibody molecules, have show
Externí odkaz:
https://doaj.org/article/1e2bc2b688c945f7bcc769f0a36809bb
Autor:
Haozhong Ding, Mohamed Altai, Wen Yin, Sarah Lindbo, Hao Liu, Javad Garousi, Tianqi Xu, Anna Orlova, Vladimir Tolmachev, Sophia Hober, Torbjörn Gräslund
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 391 (2020)
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer therapy, and targeted therapies are often used in regimens for patients with a high HER2 expression level. Despite the success of current drugs, a number
Externí odkaz:
https://doaj.org/article/9c893e988a8a499485561209b4a0df19
Autor:
Haozhong Ding, Mohamed Altai, Sara S. Rinne, Anzhelika Vorobyeva, Vladimir Tolmachev, Torbjörn Gräslund, Anna Orlova
Publikováno v:
Cancers, Vol 11, Iss 8, p 1168 (2019)
Affibody molecules are small affinity-engineered scaffold proteins which can be engineered to bind to desired targets. The therapeutic potential of using an affibody molecule targeting HER2, fused to an albumin-binding domain (ABD) and conjugated wit
Externí odkaz:
https://doaj.org/article/fb12f29c2c3440bb8f0d24d8ebd3732a
Comparison of HER2-targeted affibody conjugates loaded with auristatin- and maytansine-derived drugs
Autor:
Wen Yin, Tianqi Xu, Haozhong Ding, Jie Zhang, Vitalina Bodenko, Maria S. Tretyakova, Mikhail V. Belousov, Yongsheng Liu, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva
Publikováno v:
Journal of Controlled Release. 355:515-527
Autor:
Vorobyeva, Sergey M. Deyev, Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Javad Garousi, Sara S. Rinne, Maria Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika
Publikováno v:
Cancers; Volume 13; Issue 14; Pages: 3589
The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affini