Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Haoxun Wang"'
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background Hypoxia-mediated chemoresistance has been regarded as an important obstacle in the development of cancer treatment. Knockdown of krüppel-like factor 5 (KLF5) was reported to inhibit hypoxia-induced cell survival and promote cell
Externí odkaz:
https://doaj.org/article/96b6f9b58bcc4abebfb1c53ef8c066b4
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 2, Pp 79-85 (2018)
Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs, such as anti-viral therapeutics, anti-cancer drugs, antibiotics, anti
Externí odkaz:
https://doaj.org/article/3d782df73d3348719c8efef836f2fbec
Publikováno v:
Biochemical pharmacology.
Organic anion transporter 3 (OAT3), an indispensable basolateral membrane transporter predominantly distributed in the kidney proximal tubules, mediated the systemic clearance of substrates including clinical drugs, nutrients, endogenous and exogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b14899829ee7ffcb6534f069c1587f
https://pubmed.ncbi.nlm.nih.gov/36549459
https://pubmed.ncbi.nlm.nih.gov/36549459
Autor:
Guofeng You, Haoxun Wang
Publikováno v:
Biopharmaceutics & Drug Disposition. 38:449-457
Human organic anion transporter 3 (hOAT3) is localized at the basolateral membrane of renal proximal tubule cells and facilitates the renal secretion of numerous clinical drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, antihype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e440ba8873ec33dccdc97a13cb8503
https://doi.org/10.1002/bdd.2085
https://doi.org/10.1002/bdd.2085
Autor:
Haoxun Wang, Guofeng You
Publikováno v:
Biochim Biophys Acta Biomembr
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad array of anionic drugs from kidney, thereby avoiding their possibly toxic side effects in the body. We earlier demonstrated that OAT3 is subjected to a specific type of post-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dd4ebcef33f377a9f2445af2df909c
https://europepmc.org/articles/PMC6559824/
https://europepmc.org/articles/PMC6559824/
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body. We earlier established that activation of protein kinase C (PKC) enhances OAT3 ubiquiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bbe845e8e9ea7aa636d37522e61d0e
https://europepmc.org/articles/PMC6647857/
https://europepmc.org/articles/PMC6647857/
Publikováno v:
Pharmacol Ther
The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8556015ec5b7d4e46722d3dd584f6c
https://doi.org/10.1016/j.pharmthera.2020.107647
https://doi.org/10.1016/j.pharmthera.2020.107647
Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F320-F329
Human organic anion transporter 1 (hOAT1), expressed at the basolateral membrane of kidney proximal tubule cells, mediates the active renal secretion of a diverse array of clinically important drugs, including anti-human immunodeficiency virus therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2510a462fff8a83c6dd97401acb024e
https://doi.org/10.1152/ajprenal.00153.2016
https://doi.org/10.1152/ajprenal.00153.2016
Publikováno v:
Medicinal Research Reviews. 36:964-979
Organic anion transporters (OATs) encoded by solute carrier 22 family are localized in the epithelia of multiple organs, where they mediate the absorption, distribution, and excretion of a diverse array of negatively charged environmental toxins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::394982b39f33aeb08d876d37e848f293
https://doi.org/10.1002/med.21397
https://doi.org/10.1002/med.21397
Publikováno v:
International journal of pharmaceutics. 555
Human organic anion transporter 4 (hOAT4) belongs to a class of organic anion transporters that exert critical function in the secretion, absorption, and distribution of numerous drugs in the body, such as anti-viral drugs, anti-cancer therapeutics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457d94c5b02b6327c79e94dd810da3d8
https://pubmed.ncbi.nlm.nih.gov/30453017
https://pubmed.ncbi.nlm.nih.gov/30453017