Výsledky vyhledávání - "Haouaria Balghi"

Akademický článek

Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.

Autor: Maziar Divangahi, Haouaria Balghi, Gawiyou Danialou, Alain S Comtois, Alexandre Demoule, Sheila Ernest, Christina Haston, Renaud Robert, John W Hanrahan, Danuta Radzioch, Basil J Petrof

Publikováno v: PLoS Genetics, Vol 5, Iss 7, p e1000586 (2009)

Cystic fibrosis (CF) patients often have reduced mass and strength of skeletal muscles, including the diaphragm, the primary muscle of respiration. Here we show that lack of the CF transmembrane conductance regulator (CFTR) plays an intrinsic role in

Externí odkaz: https://doaj.org/article/922b93df895c415bad69e05d3490893f

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Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Autor: Arnaud Billet, John W. Hanrahan, Yishan Luo, Haouaria Balghi

Publikováno v: Journal of Biological Chemistry. 288:21815-21823

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride (Cl−) channel, which plays an important role in physiological anion and fluid secretion, and is defective in several diseases. Although its activation by PKA and PKC has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f709b5b256a70d446670e0f1d88d4d
https://doi.org/10.1074/jbc.m113.479360

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Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

Autor: Xuexin Zhang, Philippe Romeo, Julie Goepp, Mohamed Trebak, Benjamin Rappaz, Adeline Wohlhuter-Haddad, Paul W. Wiseman, David Y. Thomas, Pasquale Ferraro, Renaud Robert, John W. Hanrahan, Haouaria Balghi, Yishan Luo, Alexandra Evagelidis

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biolog

Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR). The most common mutation, ΔF508, causes retention of CFTR in the endoplasmic reticulum (ER). Some CF abnormalities can be explained b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0816c0917c70ec7d6c2deba2709ee26

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Mini-dystrophin Expression Down-regulates IP3-mediated Calcium Release Events in Resting Dystrophin-deficient Muscle Cells

Autor: Ludivine Mondin, Stéphane Sebille, Guy Raymond, Haouaria Balghi, Anne Cantereau, Bruno Constantin, Christian Cognard

Publikováno v: The Journal of General Physiology
Journal of General Physiology
Journal of General Physiology, Rockefeller University Press, 2006, 128 (2), pp.219-30. ⟨10.1085/jgp.200609559⟩
Journal of General Physiology, Rockefeller University Press, 2006, 128 (2), pp.219-230. ⟨10.1085/jgp.200609559⟩

International audience; We present here evidence for the enhancement, at rest, of an inositol 1,4,5-trisphosphate (IP3)-mediated calcium signaling pathway in myotubes from dystrophin-deficient cell lines (SolC1(-)) as compared to a cell line from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d807523496b049c3b9468ead852429
https://doi.org/10.1085/jgp.200609559

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Mini-dystrophin Expression Down-regulates Overactivation of G Protein–mediated IP3 Signaling Pathway in Dystrophin-deficient Muscle Cells

Autor: Vincent Thoreau, Bruno Constantin, Sylvie Patri, Elise Mok, Haouaria Balghi, Ludivine Mondin, Stéphane Sebille, Guy Raymond, Alain Kitzis, Christian Cognard

Publikováno v: Journal of General Physiology
Journal of General Physiology, Rockefeller University Press, 2006, 127 (2), pp.171-82. ⟨10.1085/jgp.200509456⟩
The Journal of General Physiology

International audience; We present here evidence for the enhancement of an inositol 1,4,5-trisphosphate (IP3) mediated calcium signaling pathway in myotubes from dystrophin-deficient cell lines (SolC1(-)) as compared to a cell line from the same orig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d138d420decf0216a07ca7401c33ef00
https://doi.org/10.1085/jgp.200509456

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An Interaction Map of Endoplasmic Reticulum Chaperones and Foldases*

Autor: Haouaria Balghi, David Y. Thomas, Leanna Y. Chen, Pekka Määttänen, Kalle Gehring, Leslie A. Scarffe, Kurt Dejgaard, Babette Schade, Alexey Yu. Denisov, Gregor Jansen, William J. Muller

Chaperones and foldases in the endoplasmic reticulum (ER) ensure correct protein folding. Extensive protein-protein interaction maps have defined the organization and function of many cellular complexes, but ER complexes are under-represented. Conseq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d032adb6289d572fee1858c25fc46104
https://europepmc.org/articles/PMC3434782/

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Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking

Autor: Donglei Zhang, Jie Liao, Graeme W. Carlile, Pierre Lesimple, Heidi M. Sampson, Haouaria Balghi, Daniel D Waller, David Y. Thomas, Romeo Phillipe, Suzana M. Anjos, Françoise Dantzer, Julie Goepp, Pasquale Ferraro, Renaud Robert, Fabiana Ciciriello, John W. Hanrahan

Publikováno v: Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology

Most cystic fibrosis is caused by mutations in CFTR that prevent its trafficking from the ER to the plasma membrane and is associated with exaggerated inflammation, altered metabolism, and diminished responses to oxidative stress. PARP-1 is activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ddc7e0be07ea010971b8615f5c6f40
http://journal.frontiersin.org/article/10.3389/fphar.2012.00165/abstract

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CFTR Modulates Orai1 Dynamics

Autor: Asmahan Abu-Arish, Paul W. Wiseman, Haouaria Balghi, Tal Arane, John W. Hanrahan

Publikováno v: Biophysical Journal. 100(3)

Calcium signaling regulates many cellular processes and is upregulated in cystic fibrosis (CF) epithelial cells. Agonists stimulate Ca2+ release from ER stores and trigger the formation of a complex between the plasma membrane (PM) Ca2+ channel Orai1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9038c08e3ea44992c22acf7a83c0f8fa

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Correction of the Delta Phe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine

Autor: Hugo R. de Jonge, Pierre Lesimple, Bart Kus, Haouaria Balghi, Na Liu, Graeme W. Carlile, Bob J. Scholte, David Y. Thomas, John W. Hanrahan, Renaud Robert, Daniela Rotin, Jie Liao, Martina Wilke

Publikováno v: Molecular Pharmacology, 77(6), 922-930. American Society for Pharmacology and Experimental Therapeutics

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells. The most common mutation Delta Phe508 leads to protein misfolding, rete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f88ad9d5c0dcd3f00b675ef3401e5c2
https://pure.eur.nl/en/publications/d83290f0-b0c8-4175-9ce9-6da88e4d1025

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Negative modulation of inositol 1,4,5-trisphosphate type 1 receptor expression prevents dystrophin-deficient muscle cells death

Autor: Stéphane Sebille, Christian Cognard, Haouaria Balghi, Ludivine Mondin, Bruno Constantin

Publikováno v: American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, American Physiological Society, 2009, 297 (5), pp.C1133-45. ⟨10.1152/ajpcell.00048.2009⟩
American Journal of Physiology-Cell Physiology, American Physiological Society, 2009, 297 (5), pp.C1133-C1145. ⟨10.1152/ajpcell.00048.2009⟩

Evidence for a modulatory effect of cyclosporin A (CsA) on calcium signaling and cell survival in dystrophin-deficient cells is presented. Our previous works strongly supported the hypothesis of an overactivation of Ca2+release via inositol 1,4,5-tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b3b329932c9bc3bd2e8553971e69df
https://hal.archives-ouvertes.fr/hal-02880242

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