Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Haoqiang Ruan"'
Autor:
Wei Hou, Zhao Chen, Chuqiao Pan, Maowei Ni, Haoqiang Ruan, Jun Song, Shiying Lu, Aman Bhasin, Benfang Helen Ruan
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1d4e9ac370a15c8c388cef4e3fbe9f
https://doi.org/10.1021/acsmedchemlett.2c00470
https://doi.org/10.1021/acsmedchemlett.2c00470
Autor:
Shiying Lu, Wei Hou, Panpan Zhu, Jinzhang Fang, Mowei Ni, Wei Zhang, Benfang Helen Ruan, Ning Xu, Di Li, Weike Su, Haoqiang Ruan, Danhui Cao, Rui Wu, Yan Yu, Renchao Ma, Zhao Chen
Publikováno v:
Journal of Medicinal Chemistry. 62:589-603
Kidney-type glutaminase [KGA/isoenzyme glutaminase C (GAC)] is becoming an important tumor metabolism target in cancer chemotherapy. Its allosteric inhibitor, CB839, showed early promise in cancer therapeutics but limited efficacy in in vivo cancer m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf9092115e369feb62d3c0b0af7dce7
https://doi.org/10.1021/acs.jmedchem.8b01198
https://doi.org/10.1021/acs.jmedchem.8b01198
Autor:
Lin Su, Benfang Helen Ruan, Wei Hou, Guanjun Zhang, Di Li, Haoqiang Ruan, Hongtao Xu, Zhi Luo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5382-5386
A diverse natural product-like (NPL) synthetic abietane diterpenoid library containing 86 compounds were obtained and the SARs were studied based on their antibacterial potential. Further in vitro cytotoxic and in silico drug-like properties evaluati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b47d392976bc849dadcb7b3075176
https://doi.org/10.1016/j.bmcl.2017.11.014
https://doi.org/10.1016/j.bmcl.2017.11.014
Autor:
Yue Zhang, Han Zhao, Jie Zhou, Yanhong Jin, Yan Yu, Di Li, Xiaoyun Ji, Shiying Lu, Benfang Helen Ruan, Haoqiang Ruan
Publikováno v:
ACS Chemical Biology. 12:3003-3011
Ebselen modulates target proteins through redox reactions with selenocysteine/cysteine residues, or through binding to the zinc finger domains. However, a recent contradiction in ebselen inhibition of kidney type glutaminase (KGA) stimulated our inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554e2f1db41f5c848a6a69eec1b91b1e
https://doi.org/10.1021/acschembio.7b00728
https://doi.org/10.1021/acschembio.7b00728
Autor:
Danhui Cao, Guanjun Zhang, Haoqiang Ruan, Lin Su, Wei Hou, Di Li, Benfang Helen Ruan, Hongtao Xu, Zhi Luo
Publikováno v:
European journal of medicinal chemistry. 138
A concise and efficient synthetic approach has been established to readily access a series of novel C-14 1,2,3-triazole-tethered dehydroabietic acid derivatives in moderate to high yields. In vitro antiproliferative activity evaluation indicated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d359d2646b1df6a82fbb321149c918d3
https://pubmed.ncbi.nlm.nih.gov/28759877
https://pubmed.ncbi.nlm.nih.gov/28759877