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Akademický článek

Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq

Autor: Yan Wang, Yijun Chen, Junpeng Gao, Haoling Xie, Yuqing Guo, Jingwei Yang, Jun’e Liu, Zonggui Chen, Qingqing Li, Mengyao Li, Jie Ren, Lu Wen, Fuchou Tang

Publikováno v: Cell Discovery, Vol 10, Iss 1, Pp 1-22 (2024)

Abstract Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual diploid cell, largely restricts the

Externí odkaz: https://doaj.org/article/863cc5ee8c764e3b8137dd097ef7eb65

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Akademický článek

Deep learning in finance assessing twitter sentiment impact and prediction on stocks

Autor: Kaifeng Guo, Haoling Xie

Publikováno v: PeerJ Computer Science, Vol 10, p e2018 (2024)

The widespread adoption of social media platforms has led to an influx of data that reflects public sentiment, presenting a novel opportunity for market analysis. This research aims to quantify the correlation between the fleeting sentiments expresse

Externí odkaz: https://doaj.org/article/bcb5560b06914d829e51eb9a483fb4b0

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Akademický článek

Study on the correlation between B vitamins and breast cancer

Autor: Siqi Xie, Mingjian Tan, Hongwan Li, Lv Li, Hengyu Zhang, Qing Wang, Sijia Li, Jiali Yang, Haoling Xie, Pengyan Chen, Dequan Liu, Rong Guo, Shicong Tang

Publikováno v: Cancer Cell International, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Relevant studies suggest that serum vitamin level is related to the risk of breast cancer, and dietary pattern and drug supplementation can significantly affect the level of vitamin in the body. Therefore, intervention of vitamin

Externí odkaz: https://doaj.org/article/fb4e675a577e406e87f30c284bc23bf6

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Akademický článek

SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform

Autor: Xiaoying Fan, Cheng Yang, Wen Li, Xiuzhen Bai, Xin Zhou, Haoling Xie, Lu Wen, Fuchou Tang

Publikováno v: Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)

Abstract There is no effective way to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. Here, we develop a novel third-generation sequencing platform-based single-cell whole-genome seque

Externí odkaz: https://doaj.org/article/b29d253a49c04813be9067e96dae4f29

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De novo assembly of human genome at single-cell levels

Autor: Haoling Xie, Wen Li, Yuqiong Hu, Cheng Yang, Jiansen Lu, Yuqing Guo, Lu Wen, Fuchou Tang

Publikováno v: Nucleic Acids Research. 50:7479-7492

Genome assembly has been benefited from long-read sequencing technologies with higher accuracy and higher continuity. However, most human genome assembly require large amount of DNAs from homogeneous cell lines without keeping cell heterogeneities, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995e1d9f598cc51273403f2187d2dc95
https://doi.org/10.1093/nar/gkac586

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Long-read-based single sperm genome sequencing for chromosome-wide haplotype phasing of both SNPs and SVs

Autor: Haoling Xie

We developed a long-read-based single-sperm genome sequencing method and a corresponding data analysis pipeline that can accurately identify crossover events and efficiently detect SVs within individual sperm cells. Importantly, without parental geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47955a0e8fe78b580398a3606142a7f4

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