Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

Autor: Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese

Externí odkaz: https://doaj.org/article/939969bbc4324201be410156a45cd9e5

A Method of Bus Network Optimization Based on Complex Network and Beidou Vehicle Location

Autor: Peixin Dong, Dongyuan Li, Jianping Xing, Haohui Duan, Yong Wu

Publikováno v: Future Internet, Vol 11, Iss 4, p 97 (2019)

Aiming at the problems of poor time performance and accuracy in bus stops network optimization, this paper proposes an algorithm based on complex network and graph theory and Beidou Vehicle Location to measure the importance of bus stops. This method

Externí odkaz: https://doaj.org/article/b2378646955645d6b4aebe5b4083476e

E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells

Autor: Ben Liu, Benjamin Parent, Sarah Mansour, Zsofia Sztupinszki, Haohui Duan, Andrew E. H. Elia, Judy Garber, Rachel Reed, Zoltan Szallasi, Nicolai Juul Birkbak, Shailja Pathania, Margaret K Gillis

Publikováno v: The Journal of Cell Biology
Duan, H, Mansour, S, Reed, R, Gillis, M K, Parent, B, Liu, B, Sztupinszki, Z, Birkbak, N, Szallasi, Z, Elia, A E H, Garber, J E & Pathania, S 2020, ' E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells ', The Journal of Cell Biology, vol. 219, no. 6, e201908192 . https://doi.org/10.1083/jcb.201908192

BRCA1/2 help maintain genomic integrity by stabilizing stalled forks for repair and thus act as tumor suppressors. Duan et al. identify the E3 ligase RFWD3 as a novel modulator of stalled fork stability in BRCA2-deficient cells and show that blocking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1fec5088ebf2c654bd0ed66268382c
https://doi.org/10.1083/jcb.201908192

BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model.

Autor: Ye He, Rivera, Joshua, Diossy, Miklos, Haohui Duan, Bowman-Colin, Christian, Reed, Rachel, Jennings, Rebecca, Novak, Jesse, Tran, Stevenson V., Cohen, Elizabeth F., Szuts, David, Giobbie-Hurder, Anita, Bronson, Roderick T., Bass, Adam J., Signoretti, Sabina, Szallasi, Zoltan, Livingston, David M., Pathania, Shailja

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 10/12/2021, Vol. 118 Issue 41, p1-11, 11p

E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.

Autor: Haohui Duan^1,2, Mansour, Sarah², Reed, Rachel³, Gillis, Margaret K.², Parent, Benjamin³, Ben Liu³, Sztupinszki, Zsofia⁴, Birkbak, Nicolai^5,6, Szallasi, Zoltan^4,7, Elia, Andrew E. H.⁸, Garber, Judy E.³, Pathania, Shailja^1,2 shailja.pathania@umb.edu

Publikováno v: Journal of Cell Biology. Jun2020, Vol. 219 Issue 6, p1-21. 21p.