Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Haohua, Qian"'
Autor:
Yong Zeng, Shasha Gao, Yichao Li, Dario Marangoni, Tharindu De Silva, Wai T. Wong, Emily Y. Chew, Xun Sun, Tiansen Li, Paul A. Sieving, Haohua Qian
Publikováno v:
Bioengineering, Vol 11, Iss 5, p 449 (2024)
Optical coherence tomography (OCT) is widely used to probe retinal structure and function. This study investigated the outer retina band (ORB) pattern and reflective intensity for the region between bands 2 and 3 (Dip) in three mouse models of inheri
Externí odkaz:
https://doaj.org/article/f03fe0017b6b4d25b49be8d7ecd9e453
Autor:
Shasha Gao, Yichao Li, David Bissig, Ethan D. Cohen, Robert H. Podolsky, Karen Lins Childers, Gregory Vernon, Sonia Chen, Bruce A. Berkowitz, Haohua Qian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/c11d2bf31d364ec19592b322e71722a4
Autor:
Shasha Gao, Yichao Li, David Bissig, Ethan D. Cohen, Robert H. Podolsky, Karen Lins Childers, Gregory Vernon, Sonia Chen, Bruce A. Berkowitz, Haohua Qian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Human and animal retinal optical coherence tomography (OCT) images show a hyporeflective band (HB) between the photoreceptor tip and retinal pigment epithelium layers whose mechanisms are unclear. In mice, HB magnitude and the external limit
Externí odkaz:
https://doaj.org/article/2ba6a17ab760416883cef9501d135fa1
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 77-85 (2019)
Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the subre
Externí odkaz:
https://doaj.org/article/2704653eb2ce4825a34dbb7d049e31be
Autor:
Bruce A Berkowitz, Robert H Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S Kern, Robin Roberts, Hailey Olds, Joydip Joy, Collin Richards, Tilman Rosales, Michael Schneider, Brennan Schilling, Arthur Orchanian, Emma Graffice, Kenan Sinan, Haohua Qian, Lamis Harp
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245161 (2021)
PurposeThe phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildt
Externí odkaz:
https://doaj.org/article/b014038296a542b78b217a813892662a
Autor:
Passley Hargrove-Grimes, Anupam K Mondal, Jessica Gumerson, Jacob Nellissery, Angel M Aponte, Linn Gieser, Haohua Qian, Robert N Fariss, Juan S Bonifacino, Tiansen Li, Anand Swaroop
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009259 (2020)
Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane turnover, signal transduction, protein recycling and degradation. Using developmental transcri
Externí odkaz:
https://doaj.org/article/8c3768f9127e45a389aa474eafd00c5f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Light adaptation changes both the sensitivity and maximum amplitude (Rmax) of the mouse photopic electroretinogram (ERG) b-wave. Using the ERG, we examined how modulation of gap junctional coupling between rod and cones alters the light-adapted ERG.
Externí odkaz:
https://doaj.org/article/2864883a33cd493587252ad25bbccac3
Autor:
Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226840 (2020)
PurposeTo test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.MethodsIntraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) o
Externí odkaz:
https://doaj.org/article/d2e55ae9cde34035a82fb7d7686e1036
Autor:
Heung-Sun Kwon, Karl Kevala, Haohua Qian, Mones Abu-Asab, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5340
It is extremely difficult to achieve functional recovery after axonal injury in the adult central nervous system. The activation of G-protein coupled receptor 110 (GPR110, ADGRF1) has been shown to stimulate neurite extension in developing neurons an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441c9d6defa6d88376ccb5e6d080d2b9
Autor:
Lian Zhao, Matthew K Zabel, Xu Wang, Wenxin Ma, Parth Shah, Robert N Fariss, Haohua Qian, Christopher N Parkhurst, Wen‐Biao Gan, Wai T Wong
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1179-1197 (2015)
Abstract Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell autonomously to rod photoreceptor degeneration by primary phago
Externí odkaz:
https://doaj.org/article/6f2f23ded19b4a14972c124a9d503157