The pathogenic mechanism of monosodium urate crystal-induced kidney injury in a rat model

Autor: Delun Li, Yimeng Li, Xuesheng Chen, Jianting Ouyang, Danyao Lin, Qiaoru Wu, Xinwen Fu, Haohao Quan, Xiaowan Wang, Shouhai Wu, Siyu Yuan, Anqi Liu, Jiaxiong Zhao, Xiaowu Liu, Gangxing Zhu, Chuang Li, Wei Mao

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Objective(MSU) crystals usually in the kidney tubules especially collecting ducts in the medulla. Previous animal models have not fully reproduced the impact of MSU on kidneys under non-hyperuricemic conditions.MethodsIn the group treated with MSU, t

Externí odkaz: https://doaj.org/article/80b47cf8c97e4066b2ba491663c0a9c8

The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications

Autor: Delun Li, Siyu Yuan, Yiyao Deng, Xiaowan Wang, Shouhai Wu, Xuesheng Chen, Yimeng Li, Jianting Ouyang, Danyao Lin, Haohao Quan, Xinwen Fu, Chuang Li, Wei Mao

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory response in the process of HUA, while dysregulation of immune cell

Externí odkaz: https://doaj.org/article/8dc09a66c4e0499da22527d1242a2996

Analysis of the chemical constituents and their metabolites in Orthosiphon stamineus Benth. via UHPLC-Q exactive orbitrap-HRMS and AFADESI-MSI techniques.

Autor: Ouyang, Jianting^1,2,3,4 (AUTHOR), Lin, Danyao^1,2,3,4 (AUTHOR), Chen, Xuesheng^1,2,3,4 (AUTHOR), Li, Yimeng^1,2,3,4 (AUTHOR), Liu, Qin¹ (AUTHOR), Li, Delun^1,2,3,4 (AUTHOR), Quan, Haohao^1,2,3,4 (AUTHOR), Fu, Xinwen^1,2,3,4 (AUTHOR), Wu, Qiaoru^1,2,3,4 (AUTHOR), Wang, Xiaowan³ (AUTHOR), Wu, Shouhai^2,3 (AUTHOR), Li, Chuang^1,2,3,4 (AUTHOR) lichuang@gzucm.edu.cn, Feng, Yi^2,4,5 (AUTHOR) lichuang@gzucm.edu.cn, Mao, Wei^1,2,3,4 (AUTHOR) lichuang@gzucm.edu.cn

Publikováno v: PLoS ONE. 6/25/2024, Vol. 19 Issue 6, p1-36. 36p.

Second Affiliated Hospital of Guangzhou University of Chinese Medicine Researchers Add New Study Findings to Research in Hyperuricemia (The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with...).

Publikováno v: Health & Medicine Week; 12/8/2023, p6338-6338, 1p