Zobrazeno 1 - 10
of 201
pro vyhledávání: '"HaoPeng Sun"'
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/94587111c29747919c84fe94174a9b19
Autor:
Hui Liu, Weimin Qiu, Tianyu Sun, Lei Wang, Chenxi Du, Yanyu Hu, Wenyuan Liu, Feng Feng, Yao Chen, Haopeng Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1781-1804 (2022)
Glioblastoma (GBM) is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable. A variety of treatment options are currently being explored to improve patient survival, including small molecule inhibitors, vira
Externí odkaz:
https://doaj.org/article/9c7d6645078b429890c7c96c6b0c65ac
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 207-238 (2020)
Blocking the biological functions of scaffold proteins and aggregated proteins is a challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be the solution, considering its ability to selectively degrade target proteins. Recen
Externí odkaz:
https://doaj.org/article/bcabdc2eb59e4a3faa27a5bb8131d408
Autor:
Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yuting Qiao, Hongzhi Lin, Feng Feng, Wenyuan Liu, Yao Chen, Zongliang Liu, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 330-343 (2020)
Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer’s disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives. Among the synthesis
Externí odkaz:
https://doaj.org/article/03e8a10a29bb415ea3f0149c944ca8d0
Autor:
You Zhou, Yanyu Hu, Xin Lu, Hongyu Yang, Qihang Li, Chenxi Du, Yao Chen, Kwon Ho Hong, Haopeng Sun
Publikováno v:
Dose-Response, Vol 18 (2020)
Alzheimer disease (AD) is the most common form of dementia characterized by the loss of cognitive abilities through the death of central neuronal cells. In this study, structure-based virtual screens of 2 central nervous system-targeted libraries fol
Externí odkaz:
https://doaj.org/article/ea40386bc0d44891a6a9c3ad02c623b5
Autor:
Jie Zhu, Hongyu Yang, Yao Chen, Hongzhi Lin, Qi Li, Jun Mo, Yaoyao Bian, Yuqiong Pei, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 496-506 (2018)
The cholinergic hypothesis has long been a “polar star” in drug discovery for Alzheimer’s disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our e
Externí odkaz:
https://doaj.org/article/791616ddf9ee4260896da9219d733aa1
Autor:
Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, Renxiang Tan, Jing Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 290-302 (2018)
Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesi
Externí odkaz:
https://doaj.org/article/245b93a03cc84762bfc4b70874b4d80a
Autor:
Hongzhi Lin, Qihang Li, Qi Li, Jie Zhu, Kai Gu, Xueyang Jiang, Qianqian Hu, Feng Feng, Wei Qu, Yao Chen, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 777-793 (2018)
Histone demethylation is a vital process in epigenetic regulation of gene expression. A number of histone demethylases are present to control the methylated states of histone. Among these enzymes, KDM4s are one subfamily of JmjC KDMs and play importa
Externí odkaz:
https://doaj.org/article/cb64bc416d7349de9d190406a383f058
Autor:
Yan Guo, Hongyu Yang, Zhongwei Huang, Sen Tian, Qihang Li, Chenxi Du, Tingkai Chen, Yang Liu, Haopeng Sun, Zongliang Liu
Publikováno v:
Molecules, Vol 25, Iss 3, p 489 (2020)
A series of novel compounds 6a−h, 8i−1, 10s−v, and 16a−d were synthesized and evaluated, together with the known analogs 11a−f, for their inhibitory activities towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The inhibi
Externí odkaz:
https://doaj.org/article/063f4d049ef742e3bd980ad1190b1960
Publikováno v:
PeerJ, Vol 6, p e4206 (2018)
Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our re
Externí odkaz:
https://doaj.org/article/a6bb04e335784061a304dc445d989f7d